Abstract: There is provided a method of calculating a temperature corrected sample position in an interferometric microscope, the method comprising projecting an autofocus beam onto the sample location to form a reflected ring of radiation, detecting an uncalibrated radius. R, of a peak of the annulus of the reflected ring which indicates an uncalibrated sample position, detecting one or more of the width of the annulus or an intensity of the annulus and calculating a calibrated radius Rnorm using at least one of the width of the annulus or the intensity of the annulus to determine the temperature dependent corrected sample position.

Abstract: A distributed computing system, comprising a control node and a plurality of provider nodes. One or more of the provider nodes are a customer premises equipment (CPE), each CPE comprising one of: a broadband router, a modem, a residential gateway. The control node and the plurality of provider nodes are arranged in a grid computing network to provide a distributed computational resource by aggregating surplus computational resources at the plurality of provider nodes.

Abstract: A critical illumination device is provided. The critical illumination device comprise a uniform illumination of an object in a reflected light microscope, the critical illumination device comprising a coherent or partially coherent light source; an optical fibre coupled with the light source, wherein the fibre comprises a core with a diameter of at least 15 microns and a numerical aperture of 0.1 to 0.5; and at least one collimator lens positioned at the focal length from the tip of the optical fibre, wherein the collimator lens is configured to match the numerical aperture of the optical fibre to couple light out of optical fibre.

Abstract: Method and system comprising determining electricity usage of a plurality of devices operating within one or more local networks. Maintaining in a data store external to each local network, data representing the determined electricity usage for each device of the plurality of devices and data identifying the device local network of the device.

Abstract: The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

Abstract: The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

Abstract: There is provided a method of calculating a temperature corrected sample position in an interferometric microscope, the method comprising projecting an autofocus beam onto the sample location to form a reflected ring of radiation, detecting an uncalibrated radius. R, of a peak of the annulus of the reflected ring which indicates an uncalibrated sample position, detecting one or more of the width of the annulus or an intensity of the annulus and calculating a calibrated radius Rnorm using at least one of the width of the annulus or the intensity of the annulus to determine the temperature dependent corrected sample position.

Abstract: The invention relates the use of single particle light scattering, preferably interferometric scattering microscopy (also referred to herein as iSCAT), to measure the concentration of a particle in a solution. The invention furthermore relates to the use of light scattering to detect lipoprotein particles in a sample, and to related diagnostic and treatment methods.

Abstract: A method comprising the steps of: measuring a first series of interferometric scattering microscopy (iSCAT) signals and a second series of iSCAT signals of a sample on a sample holder, the sample comprising a particle dissolved in solution; deriving an illumination heterogeneity for the first series of iSCAT signals; deriving a reflectance profile for the first series of iSCAT signals based on the illumination heterogeneity and/or the second series of iSCAT signals; measuring a third series of iSCAT signals of the sample on the sample holder; and normalizing an interferometric contrast for the third series of iSCAT signals with the reflectance profile.