Patents by Inventor Gayatri VEDANTAM

Gayatri VEDANTAM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR MODIFYING BACTERIAL GENE EXPRESSION
    Publication number: 20230405130
    Abstract: Provided herein are compositions and methods for treating and preventing bacterial infections. In particular, provided herein are targeted bola-amphiphile: nucleic acid complexes specific for bacteria.
    Type: Application
    Filed: November 5, 2021
    Publication date: December 21, 2023
    Inventors: David B. Stewart, Gayatri Vedantam, Arun K. Sharma, Jacek KRZEMINSKI
  • Compositions comprising recombinant probiotic bacteria and methods of use thereof
    Patent number: 11839649
    Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: December 12, 2023
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, The United States Government as represented by the Department of Veterans Affairs
    Inventors: Gayatri Vedantam, Virinchipuram K. Viswanathan, Michael Mallozzi
  • Methods, systems, and compositions for inhibiting virulence of A/E family pathogens
    Patent number: 11484603
    Abstract: The present invention features methods, systems, and compositions for inhibiting function of EspZ or an EspZ equivalent, and for inhibiting or reducing virulence of pathogens that utilize EspZ or EspZ equivalent, such as those pathogens that belong to the attaching-effacing (A/E) family. The methods may feature the use of an inhibitor peptide that targets at least a portion of EspZ, such as one of the transmembrane domains. In certain embodiments, the inhibitor peptide disrupts proper dimerization or oligomerization of EspZ.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 1, 2022
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Virinchipuram K. Viswanathan, Gayatri Vedantam
  • Compositions comprising a chimeric bacterial surface layer protein and methods of use thereof
    Patent number: 11299520
    Abstract: The invention features engineered probiotic lacto acid bacteria (LAB) expressing a chimeric Clostridium difficile/Lactobacillus acidophilus SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: April 12, 2022
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Gayatri Vedantam, Virinchipuram Viswanathan
  • COMPOSITIONS COMPRISING RECOMBINANT PROBIOTIC BACTERIA AND METHODS OF USE THEREOF
    Publication number: 20210205431
    Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Application
    Filed: January 22, 2021
    Publication date: July 8, 2021
    Inventors: Gayatri VEDANTAM, Virinchipuram K. VISWANATHAN, Michael MALLOZZI
  • METHODS, SYSTEMS, AND COMPOSITIONS FOR INHIBITING VIRULANCE OF A/E FAMILY PATHOGENS
    Publication number: 20210008221
    Abstract: The present invention features methods, systems, and compositions for inhibiting function of EspZ or an EspZ equivalent, and for inhibiting or reducing virulence of pathogens that utilize EspZ or EspZ equivalent, such as those pathogens that belong to the attaching-effacing (A/E) family. The methods may feature the use of an inhibitor peptide that targets at least a portion of EspZ, such as one of the transmembrane domains. In certain embodiments, the inhibitor peptide disrupts proper dimerization or oligomerization of EspZ.
    Type: Application
    Filed: March 30, 2018
    Publication date: January 14, 2021
    Applicant: Arizona Board of Regents on Behalf of The University of Arizona
    Inventors: Virinchipuram K. VISWANATHAN, Gayatri VEDANTAM
  • COMPOSITIONS COMPRISING RECOMBINANT PROBIOTIC BACTERIA AND METHODS OF USE THEREOF
    Publication number: 20200237888
    Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Application
    Filed: March 9, 2020
    Publication date: July 30, 2020
    Inventors: Gayatri VEDANTAM, Virinchipuram K. VISWANATHAN, Michael MALLOZZI
  • COMPOSITIONS COMPRISING A CHIMERIC BACTERIAL SURFACE LAYER PROTEIN AND METHODS OF USE THEREOF
    Publication number: 20200239527
    Abstract: The invention features engineered probiotic lacto acid bacteria (LAB) expressing a chimeric Clostridium difficile/Lactobacillus acidophilus SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Application
    Filed: September 25, 2018
    Publication date: July 30, 2020
    Inventors: Gayatri VEDANTAM, Virinchipuram VISWANATHAN
  • Compositions comprising recombinant probiotic bacteria and methods of use thereof
    Patent number: 10583186
    Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: March 10, 2020
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Gayatri Vedantam, Virinchipuram K. Viswanathan, Michael Mallozzi
  • COMPOSITIONS COMPRISING RECOMBINANT PROBIOTIC BACTERIA AND METHODS OF USE THEREOF
    Publication number: 20180000919
    Abstract: The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
    Type: Application
    Filed: January 22, 2016
    Publication date: January 4, 2018
    Inventors: Gayatri VEDANTAM, Virinchipuram K. VISWANATHAN, Michael MALLOZZI