Abstract: A method for determining tobacco-specific nitrosamines (TSNAs) in cigarette smoke using one-step clean-up coupled with LC-MS/MS is provided, including the following steps: collecting a particulate matter of mainstream cigarette smoke with a Cambridge filter pad, mixing the particulate matter of mainstream cigarette smoke, an internal standards solution and water in a 50 mL plastic centrifuge tube, and vortexing the resulting mixture at room temperature to allow extraction; transferring an extraction solution after filtration to a new centrifuge tube, adding dichloromethane, and vortexing the resulting mixture; centrifuging to collect a dichloromethane extraction solution in a lower layer to another centrifuge tube, and placing the centrifuge tube in a water bath to remove dichloromethane; dissolving the resulting extraction solution in water, and transferring the resulting solution to an autosampler vial for LC-MS/MS analysis.

Abstract: A method for determining tobacco-specific nitrosamines (TSNAs) in tobacco using one-step clean-up coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) is provided, including the following steps: destemming flue-cured tobacco or sun-cured tobacco, drying, milling, and passing through a sieve; mixing the resulting tobacco, an internal standards solution and water in a plastic centrifuge tube, and vortexing the resulting mixture at room temperature to allow extraction; transferring an extraction solution after filtration to a new centrifuge tube, adding dichloromethane, and vortexing the resulting mixture; centrifuging to collect a dichloromethane extraction solution in a lower layer to another centrifuge tube, and placing the centrifuge tube in a water bath to remove dichloromethane; dissolving the resulting extraction solution in water, and transferring the resulting solution to an autosampler vial for LC-MS/MS analysis.

Abstract: A method for reliable data synchronization within a network is disclosed. The producer system stories data in a persistent data store and produces one or more data updates. The producer system simultaneously transmits the data updates to a consumer system and initiating storage of the data updates at the producer system. When storage of the data updates at the producer system is complete, the producer system transmits a first acknowledgment to the consumer system. The producer system determines whether a second acknowledgment has been received from the consumer system, wherein the second acknowledgment indicates that the consumer system has successfully stored the data updates at the consumer system. In accordance with a determination that the second acknowledgment has been received from the consumer system, the producer system changes the temporary status of the data updates stored at the producer system to a permanent status.

Abstract: Implementations include providing, by a computer-executed migration advisor executing within a run-time of a source database system, a query data set including queries processed by the source database system during production use of the source database system, providing, by the migration advisor, an object data set including data representative of database objects stored within a database of the source database system, generating, by the migration advisor, a list of query-level features and a list of object-level features, each feature in the list of query-level features and each feature in the list of object-level features including a feature that is deprecated in a target database system, resolving one or more issues represented by features of one or more of the list of query-level features and the list of object-level features, and executing migration of the database of the source database system to the database of the target database system.

Abstract: Disclosed herein are system, method, and computer program product (computer-readable storage medium) embodiments for implementing memory management via dynamic tiering pools. An embodiment operates by initializing a first memory pool of a first tier, and invoking first and second function calls to allocate memory to the first memory pool. Responsive to these function calls, an OS may allocate differently-sized memory elements for attachment to the first memory pool, from a memory free store managed by the OS. A second memory pool, of a second tier, may be further initialized, and a third function call may be invoked, to allocate memory to the second memory pool. Here, in response to the third function call, the first memory pool may reallocate the second memory element from the first memory pool for attachment to the second memory pool.

Abstract: Disclosed herein are system, method, and computer program product (computer-readable storage medium) embodiments for implementing memory management via dynamic tiering pools. An embodiment operates by initializing a first memory pool of a first tier, and invoking first and second function calls to allocate memory to the first memory pool. Responsive to these function calls, an OS may allocate differently-sized memory elements for attachment to the first memory pool, from a memory free store managed by the OS. A second memory pool, of a second tier, may be further initialized, and a third function call may be invoked, to allocate memory to the second memory pool. Here, in response to the third function call, the first memory pool may reallocate the second memory element from the first memory pool for attachment to the second memory pool.

Abstract: A method for reliable data synchronization within a network is disclosed. The producer system stories data in a persistent data store and produces one or more data updates. The producer system simultaneously transmits the data updates to a consumer system and initiating storage of the data updates at the producer system. When storage of the data updates at the producer system is complete, the producer system transmits a first acknowledgment to the consumer system. The producer system determines whether a second acknowledgment has been received from the consumer system, wherein the second acknowledgment indicates that the consumer system has successfully stored the data updates at the consumer system. In accordance with a determination that the second acknowledgment has been received from the consumer system, the producer system changes the temporary status of the data updates stored at the producer system to a permanent status.

Abstract: A method for reliable data synchronization within a network is disclosed. The producer system stories data in a persistent data store and produces one or more data updates. The producer system simultaneously transmits the data updates to a consumer system and initiating storage of the data updates at the producer system. When storage of the data updates at the producer system is complete, the producer system transmits a first acknowledgment to the consumer system. The producer system determines whether a second acknowledgment has been received from the consumer system, wherein the second acknowledgment indicates that the consumer system has successfully stored the data updates at the consumer system. In accordance with a determination that the second acknowledgment has been received from the consumer system, the producer system changes the temporary status of the data updates stored at the producer system to a permanent status.

Abstract: Disclosed in some examples is a method, the method including detecting that an RDMS is recovering from a failure; sending a request for a last committed transaction on a replication component to the replication component; receiving, from the replication component, the last committed transaction which identifies a transaction that was the last committed transaction at a replication component at a time of RDMS failure; determining that a transaction log on the RDMS includes a transaction that had not yet been replicated at the time of RDMS failure which was committed on the transaction log subsequent to the last committed transaction received from the replication component; and based on that determination rolling back the transaction that had not yet been replicated at the time of RDMS failure.

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

Abstract: Disclosed in some examples is a method, the method including detecting that an RDMS is recovering from a failure; sending a request for a last committed transaction on a replication component to the replication component; receiving, from the replication component, the last committed transaction which identifies a transaction that was the last committed transaction at a replication component at a time of RDMS failure; determining that a transaction log on the RDMS includes a transaction that had not yet been replicated at the time of RDMS failure which was committed on the transaction log subsequent to the last committed transaction received from the replication component; and based on that determination rolling back the transaction that had not yet been replicated at the time of RDMS failure.

Abstract: Disclosed in some examples is a method, the method including detecting that an RDMS is recovering from a failure; sending a request for a last committed transaction on a replication component to the replication component; receiving, from the replication component, the last committed transaction which identifies a transaction that was the last committed transaction at a replication component at a time of RDMS failure; determining that a transaction log on the RDMS includes a transaction that had not yet been replicated at the time of RDMS failure which was committed on the transaction log subsequent to the last committed transaction received from the replication component; and based on that determination rolling back the transaction that had not yet been replicated at the time of RDMS failure.

Abstract: A method for reliable data synchronization within a network is disclosed. The producer system stories data in a persistent data store and produces one or more data updates. The producer system simultaneously transmits the data updates to a consumer system and initiating storage of the data updates at the producer system. When storage of the data updates at the producer system is complete, the producer system transmits a first acknowledgment to the consumer system. The producer system determines whether a second acknowledgment has been received from the consumer system, wherein the second acknowledgment indicates that the consumer system has successfully stored the data updates at the consumer system. In accordance with a determination that the second acknowledgment has been received from the consumer system, the producer system changes the temporary status of the data updates stored at the producer system to a permanent status.

Abstract: Disclosed in some examples is a method, the method including detecting that an RDMS is recovering from a failure; sending a request for a last committed transaction on a replication component to the replication component; receiving, from the replication component, the last committed transaction which identifies a transaction that was the last committed transaction at a replication component at a time of RDMS failure; determining that a transaction log on the RDMS includes a transaction that had not yet been replicated at the time of RDMS failure which was committed on the transaction log subsequent to the last committed transaction received from the replication component; and based on that determination rolling back the transaction that had not yet been replicated at the time of RDMS failure.

Abstract: The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

Abstract: The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

Abstract: The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

Abstract: The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

Abstract: The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.