Patents by Inventor Ge Peng

Ge Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
    Publication number: 20240124475
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: September 28, 2023
    Publication date: April 18, 2024
    Inventors: Daniel W. Robbins, Arthur T. SANDS, Joel MCINTOSH, Jeffrey MIHALIC, Jeffrey WU, Daisuke KATO, Dahlia WEISS, Ge PENG
  • Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
    Patent number: 11866442
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: July 28, 2022
    Date of Patent: January 9, 2024
    Assignee: NURIX THERAPEUTICS, INC.
    Inventors: Daniel W. Robbins, Arthur T. Sands, Joel McIntosh, Jeffrey Mihalic, Jeffrey Wu, Daisuke Kato, Dahlia Weiss, Ge Peng
  • COMPOUNDS FOR INHIBITING OR DEGRADING TARGET PROTEINS, COMPOSITIONS, COMPRISING THE SAME, METHODS OF THEIR MAKING, AND METHODS OF THEIR USE
    Publication number: 20230158151
    Abstract: Provided herein are heterobifunctional compounds which find utility as modulators of targeted ubiquitination. Also provided herein are pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds, and compositions in the treatment of various diseases, conditions, or disorders.
    Type: Application
    Filed: August 16, 2022
    Publication date: May 25, 2023
    Inventors: Eric Wegryzniak, Joel McIntosh, Daisuke Kato, Jeffrey Mihalic, Ge Peng
  • BIFUNCTIONAL COMPOUNDS FOR GRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
    Publication number: 20230024442
    Abstract: The present invention relates to compounds of formula (I) useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: November 8, 2019
    Publication date: January 26, 2023
    Inventors: Daniel W. ROBBINS, Ge PENG, Jeffrey MIHALIC, Arthur T. SANDS
  • BIFUNCTIONAL COMPOUNDS FOR DEGRADING BTK VIA UBIQUITIN PROTEOSOME PATHWAY
    Publication number: 20230029378
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: July 28, 2022
    Publication date: January 26, 2023
    Inventors: Daniel W. ROBBINS, Arthur T. SANDS, Joel MCINTOSH, Jeffrey MIHALIC, Jeffrey WU, Daisuke KATO, Dahlia WEISS, Ge PENG
  • Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
    Patent number: 11479556
    Abstract: The present invention relates to compounds useful for degrading BTK via a ubiquitin proteolytic pathway. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: October 25, 2022
    Assignee: NURIX THERAPEUTICS, INC.
    Inventors: Daniel W. Robbins, Arthur T. Sands, Joel McIntosh, Jeffrey Mihalic, Jeffrey Wu, Daisuke Kato, Dahlia Weiss, Ge Peng
  • Pegylated carfilzomib compounds
    Patent number: 11077198
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 3, 2021
    Assignee: AMGEN INC.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • Pegylated Carfilzomib Compounds
    Publication number: 20200376131
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Application
    Filed: April 23, 2020
    Publication date: December 3, 2020
    Applicant: AMGEN INC.
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 10682419
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: June 16, 2020
    Assignee: ONYX THERAPEUTICS, INC.
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Pegylated carfilzomib compounds
    Patent number: 10675353
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: June 9, 2020
    Assignee: AMGEN INC.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • PEGYLATED CARFILZOMIB COMPOUNDS
    Publication number: 20200069808
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Application
    Filed: November 5, 2019
    Publication date: March 5, 2020
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Pegylated carfilzomib compounds
    Patent number: 10517954
    Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: December 31, 2019
    Assignee: Amgen Inc.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    Patent number: 10385014
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: August 20, 2019
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
    Publication number: 20180258032
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 13, 2018
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20180147291
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: January 29, 2018
    Publication date: May 31, 2018
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    Patent number: 9944592
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 17, 2018
    Assignee: XENOPORT, INC.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 9878047
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: January 30, 2018
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • PEGYLATED CARFILZOMIB COMPOUNDS
    Publication number: 20170340746
    Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 30, 2017
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
    Publication number: 20170190657
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: December 22, 2016
    Publication date: July 6, 2017
    Applicant: XENOPORT, INC.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS
    Publication number: 20160263234
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: March 9, 2016
    Publication date: September 15, 2016
    Inventors: Pasit Phiasivongsa, Gary W. Luehr, Ge Peng, Kolbot By, Shabbir T. Anik