Abstract: Disclosed herein are compositions and methods for treating cancer patients who have been previously treated with one or more chemotherapeutic agents and have developed at least partial resistance to such chemotherapeutic agents. Also disclosed are methods for selecting compounds suitable for treatment of cancer in a patient who has become resistant to an inhibitor of a receptor tyrosine kinase (RTK).

Abstract: The dumpling wrapping device contains a filling provision member, two wrapping members, and two shaping members. The filling provision member distributes dumpling fillings to feed two production lines of dumplings, each involving a wrapping member and a shaping member. Two pairs of rotors in the filling provision member drives dumpling fillings towards the wrapping members through two tubes. The wrapping members wrap the dumpling fillings from the tubes with dough. The dough wrapped fillings are pressed by the shaping members into dumplings of desired shape and size. Positioning members are configured under the shaping members so that the shaping members can be conveniently replaced and cleaned.

Abstract: Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.

Abstract: The dumpling wrapping device contains a filling provision member, two wrapping members, and two shaping members. The filling provision member distributes dumpling fillings to feed two production lines of dumplings, each involving a wrapping member and a shaping member. Two pairs of rotors in the filling provision member drives dumpling fillings towards the wrapping members through two tubes. The wrapping members wrap the dumpling fillings from the tubes with dough. The dough wrapped fillings are pressed by the shaping members into dumplings of desired shape and size. Positioning members are configured under the shaping members so that the shaping members can be conveniently replaced and cleaned.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.

Abstract: Provided herein are methods of using modified matrix metalloprotease (MMP) enzymes that exhibit regulated activity in the presence of calcium. The methods include conditionally controlling the activity of the MMPs through the use of calcium to treat fibrotic diseases or conditions involving a component of the extracellular matrix (ECM).

Abstract: Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.

Abstract: Modified PH20 hyaluronidase polypeptides that exhibit stability and activity under thermal stress conditions are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.

Abstract: Provided herein are methods of using modified matrix metalloprotease (MMP) enzymes that exhibit regulated activity in the presence of calcium. The methods include conditionally controlling the activity of the MMPs through the use of calcium to treat fibrotic diseases or conditions involving a component of the extracellular matrix (ECM).

Abstract: A sensorless commutation circuit and sensorless driving apparatus for a brushless motor includes a voltage divided unit, a control signal output unit, a switch unit and a comparison unit. The voltage divided unit outputs a voltage divided signal according to a phase voltage signal of the brushless motor. The control signal output unit outputs a filter control signal, wherein the filter control signal has a same switching cycle as a pulse width modulation control signal that drives the brushless motor. The switch unit is coupled to the control signal output unit and the voltage divided unit, and outputs a comparison signal according to the filter control signal and the voltage divided signal. The comparison unit is coupled to the switch unit, and outputs a correct commutation signal according to the comparison signal.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.

Abstract: A sensorless commutation circuit and sensorless driving apparatus for a brushless motor includes a voltage divided unit, a control signal output unit, a switch unit and a comparison unit. The voltage divided unit outputs a voltage divided signal according to a phase voltage signal of the brushless motor. The control signal output unit outputs a filter control signal, wherein the filter control signal has a same switching cycle as a pulse width modulation control signal that drives the brushless motor. The switch unit is coupled to the control signal output unit and the voltage divided unit, and outputs a comparison signal according to the filter control signal and the voltage divided signal. The comparison unit is coupled to the switch unit, and outputs a correct commutation signal according to the comparison signal.

Abstract: The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.

Abstract: Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.