Patents by Inventor Ge Zou

Ge Zou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperazine compounds for the treatment of autoimmune disease
    Patent number: 11952363
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: April 9, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Fabian Dey, Zongxing Qiu, Wei Zhu, Ge Zou
  • Heterocyclic compounds as PI3K-? inhibitors
    Patent number: 11773102
    Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: October 3, 2023
    Assignee: Incyte Corporation
    Inventors: Artem Shvartsbart, Stacey Shepard, Andrew P. Combs, Lixin Shao, Nikoo Falahatpisheh, Ge Zou, Andrew W. Buesking, Richard B. Sparks, Eddy W. Yue, Ravi Kumar Jalluri
  • PYRIDINONE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230295109
    Abstract: The present invention relates to compounds of formula (I), (I), wherein R1, R2, R3, R4 and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 21, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Fabian DEY, Xin HONG, Xuefei TAN, Jiasu XU, Wei ZHU, Ge ZOU
  • IMIDAZO[1,2-A]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230279001
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and A are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 7, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Jianguo CHEN, Fabian DEY, Xin HONG, Xuefei TAN, Jiasu XU, Weixing ZHANG, Wei ZHU, Ge ZOU
  • HYDRO-1H-PYRROLO[1,2-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230219959
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 17, 2020
    Publication date: July 13, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Dongdong CHEN, Fabian DEY, Dong DING, Hongtao XU, Wei ZHU, Ge ZOU
  • Benzothiazole compounds for the treatment of autoimmune diseases
    Patent number: 11639352
    Abstract: The present invention relates to compounds of formula (I), (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: May 2, 2023
    Assignee: Hoffman-La Roche Inc.
    Inventors: Wei Zhu, Ge Zou, Fabian Dey
  • 1,8-NAPHTHYRIDIN-2-ONE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230041743
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3, m and n are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 24, 2020
    Publication date: February 9, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hong SHEN, Xiaoqing WANG, Hongtao XU, Zhisen ZHANG, Wei ZHU, Ge ZOU
  • HYDROPYRAZINO[1,2-D][1,4]DIAZEPINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230034723
    Abstract: The present invention relates to compounds of formula (I), wherein R1 and R3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: October 29, 2020
    Publication date: February 2, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Hongtao XU, Zhisen ZHANG, Wei ZHU, Ge Zou
  • TRIAZATRICYCLE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230015242
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3 and n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 17, 2020
    Publication date: January 19, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Hong SHEN, Hongtao XU, Wei ZHU, Ge ZOU
  • HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS
    Publication number: 20230009843
    Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Application
    Filed: June 24, 2021
    Publication date: January 12, 2023
    Inventors: Artem Shvartsbart, Stacey Shepard, Andrew P. Combs, Lixin Shao, Nikoo Falahatpisheh, Ge Zou, Andrew W. Buesking, Richard B. Sparks, Eddy W. Yue, Ravi Kumar Jalluri
  • Cyclic amidine compounds for the treatment of autoimmune disease
    Patent number: 11548884
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as antagonist of TLR7 and/or TLR8 and/or TLR9 in the treatment of autoimmune diseases as well as auto-inflammation diseases.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: January 10, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Zongxing Qiu, Hong Shen, Wei Zhu, Fabian Dey, Ge Zou, Hongtao Xu
  • HYDROPYRAZINO[1,2-B]ISOQUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20230002375
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 10, 2020
    Publication date: January 5, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Fabian DEY, Dong DING, Hongtao XU, Wei ZHU, Ge ZOU
  • PIPERIDINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20220395496
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2, R3, R4 and R5 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 14, 2020
    Publication date: December 15, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Taishan HU, Buyu KOU, Haixia LIU, Hong SHEN, Wei ZHU, Ge ZOU
  • Tetrahydro-1H-pyrazino[2,1-a]isoindolylquinoline Compounds for the Treatment of Autoimmune Disease
    Publication number: 20210371432
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R6, m and n are I a described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: June 3, 2019
    Publication date: December 2, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: FABIAN DEY, HONG SHEN, HONGTAO XU, HONGYING YUN, GE ZOU, WEI ZHU
  • CYCLIC AMIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20210340134
    Abstract: The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds as antagonist of TLR7 and/or TLR8 and/or TLR9 in the treatment of autoimmune diseases as well as auto-inflammation diseases.
    Type: Application
    Filed: September 6, 2018
    Publication date: November 4, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Zongxing Qiu, Hong Shen, Wei Zhu, Fabian Dey, Ge Zou, Hongtao Xu
  • BENZOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20210340136
    Abstract: The present invention relates to compounds of formula (I), (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 4, 2018
    Publication date: November 4, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Wei Zhu, Ge Zou, Fabian Dey
  • PIPERAZINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE
    Publication number: 20210269423
    Abstract: The present invention relates to compounds of formula (I), wherein R1 to R4 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: July 22, 2019
    Publication date: September 2, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: FABIAN DEY, ZONGXING QIU, WEI ZHU, GE ZOU
  • Heterocyclic compounds as PI3K-y inhibitors
    Patent number: 11091491
    Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: August 17, 2021
    Assignee: Incyte Corporation
    Inventors: Artem Shvartsbart, Stacey Shepard, Andrew P. Combs, Lixin Shao, Nikoo Falahatpisheh, Ge Zou, Andrew W. Buesking, Richard B. Sparks, Eddy W. Yue, Ravi Kumar Jalluri
  • Aza-heteroaryl compounds as PI3K-gamma inhibitors
    Patent number: 10596184
    Abstract: The present invention provides aza-heteroaryl derivatives of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, R4, R5, and R6 are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (PI3K?) and are useful in the treatment of diseases related to the activity of PI3K? including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: March 24, 2020
    Assignee: Incyte Corporation
    Inventors: Ge Zou, Andrew P. Combs
  • HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS
    Publication number: 20200031837
    Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
    Type: Application
    Filed: October 1, 2019
    Publication date: January 30, 2020
    Inventors: Artem Shvartsbart, Stacey Shepard, Andrew P. Combs, Lixin Shao, Nikoo Falahatpisheh, Ge Zou, Andrew W. Buesking, Richard B. Sparks, Eddy W. Yue, Ravi Kumar Jalluri