Patents by Inventor Geert Raes

Geert Raes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE CHECKPOINTS
    Publication number: 20240067722
    Abstract: The present disclosure relates to field of immune checkpoints in onco-immunology and their identification as potential targets for the treatment of cancer patients: it provides VHHs (Single-domain antibody fragments, also known as ‘heavy-chain variable domains’ or ‘nanobodies’) to detect and quantify in a non-invasive way the immune checkpoint LAG-3.
    Type: Application
    Filed: December 20, 2021
    Publication date: February 29, 2024
    Inventors: Karine Breckpot, Katrijn Broos, Nick Devoogdt, Quentin Lecocq, Marleen Keyaerts, Geert Raes
  • Human PD-L1-binding immunoglobulins
    Patent number: 11858960
    Abstract: The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human Programmed Death Ligand-1 (huPDL1) and to applications of such polypeptides such as for use as a medicament or for use as diagnostic agent, for example as an immunotracer.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: January 2, 2024
    Assignee: VRIJE UNIVERSITEIT BRUSSEL
    Inventors: Jo Van Ginderachter, Geert Raes, Nick Devoogdt, Marleen Keyaerts, Quentin Lecocq, Catarina Xavier, Karine Breckpot, Katrijn Broos, Jessica Bridoux
  • HUMAN PD-L1-BINDING IMMUNOGLOBULINS
    Publication number: 20210147546
    Abstract: The invention relates to polypeptides, in particular polypeptides comprising an immunoglobulin domain, binding to human Programmed Death Ligand-1 (huPDL1) and to applications of such polypeptides such as for use as a medicament or for use as diagnostic agent, for example as an immunotracer.
    Type: Application
    Filed: March 1, 2019
    Publication date: May 20, 2021
    Applicant: Vrije Universiteit Brussel
    Inventors: Jo Van Ginderachter, Geert Raes, Nick Devoogdt, Marleen Keyaerts, Quentin Lecocq, Catarina Xavier, Karine Breckpot, Katrijn Broos, Jessica Bridoux
  • Targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9913920
    Abstract: The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: March 13, 2018
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain
    Patent number: 9617339
    Abstract: The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: April 11, 2017
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Patrick De Baetselier, Geert Raes, Steve Schoonooghe, Jens De Vos, Tony Lahoutte, Nick Devoogdt, Sophie Hernot, Gezim Bala, Simon Tierens
  • Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9556273
    Abstract: The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 31, 2017
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Jo Van Ginderachter, Patrick De Baetselier, Nick Devoogdt, Tony Lahoutte, Damya Laoui, Kiavash Movahedi, Geert Raes, Steve Schoonooghe
  • ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR USE IN CARDIOVASCULAR DISEASES
    Publication number: 20160024213
    Abstract: The disclosure relates to the field of cardiovascular diseases. In particular, immunoglobulin single variable domains directed against macrophage mannose receptor (MMR) are provided that can be used in the diagnosis, prognosis and/or monitoring of cardiovascular diseases or as therapeutics. Also, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are useful at different stages of cardiovascular diseases, including post-infarction cardiovascular events. Further, the anti-macrophage mannose receptor (MMR) immunoglobulin single variable domains of the disclosure are particularly useful for the in vivo targeting and/or imaging of vulnerable atherosclerotic plaques.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Patrick De Baetselier, Geert Raes, Steve Schoonooghe, Jens De Vos, Tony Lahoutte, Nick Devoogdt, Sophie Hernot, Gezim Bala, Simon Tierens
  • TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20150335770
    Abstract: The disclosure relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Application
    Filed: August 6, 2015
    Publication date: November 26, 2015
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Targeting and in vivo imaging of tumor-associated macrophages
    Patent number: 9101674
    Abstract: The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: August 11, 2015
    Assignees: VIB VZW, Vrije Universiteit Brussel
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20150093336
    Abstract: The disclosure relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including single-domain antibodies (sdAbs), against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
    Type: Application
    Filed: March 15, 2013
    Publication date: April 2, 2015
    Inventors: Jo Van Ginderachter, Patrick De Baetselier, Nick Devoogdt, Tony Lahoutte, Damya Laoui, Kiavash Movahedi, Geert Raes, Steve Schoonooghe
  • TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES
    Publication number: 20120301394
    Abstract: The invention relates to activities and characteristics of tumor-associated macrophages (TAMs). In particular, immunoglobulin single variable domains are provided against markers of TAMs, and methods using the same for in vivo imaging of tumor cells, as well as cancer diagnostics and therapeutics.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 29, 2012
    Applicant: VIB VZW
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • Selective targeting of intratumoral cells
    Publication number: 20110262348
    Abstract: The present invention relates to the field of tumor growth and biology. The invention relates to activities and characteristics of tumor-associated macrophages, and uses of such for the diagnosis and treatment of cancer and tumor growth.
    Type: Application
    Filed: March 29, 2011
    Publication date: October 27, 2011
    Applicants: Vrije Universiteit Brussel, VIB VZW
    Inventors: Kiavash Movahedi, Damya Laoui, Steve Schoonooghe, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter, Nick Devoogdt, Tony Lahoutte
  • NOVEL ADIPOCYTOKINE VISFATIN/PBEF1 IS AN APOPTOSIS ASSOCIATED FACTOR INDUCED IN MONOCYTES DURING IN VIVO HIV-1 INFECTION
    Publication number: 20100184031
    Abstract: The present invention relates to the use of monocyte markers for diagnostic, prognostic or theranostic applications during diseases and syndromes caused by HIV infection. More specifically, it relates to a method comprising isolation of monocytes and determining gene expression, preferably PBEF1 gene expression. The method is useful to determine the evolution of the disease or can be used to evaluate the efficacy of a treatment.
    Type: Application
    Filed: June 5, 2008
    Publication date: July 22, 2010
    Inventors: Geert Raes, Patrick De Baetselier, Rafael Van den Bergh, Guido Vanham
  • Markers for alternatively activated macrophages
    Patent number: 7514217
    Abstract: The present invention relates to novel markers for alternatively activated macrophages. More specifically, the present invention relates to the use of galactose-type C-type lectins as surface markers that allows rapid identification and sorting of the alternative macrophages. Such identifications can be useful in diseases where there is an imbalance between proinflammatory and anti-inflammatory immune reactions.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: April 7, 2009
    Assignees: Vlaams Interuniversitair Instituut voor Biotechnologie VZW, Vrije Universiteit Brussel
    Inventors: Geert Raes, Gholamreza Hassanzadeh Ghassabeh, Patrick De Baetselier
  • Novel markers for alternatively activated macrophages
    Publication number: 20060183162
    Abstract: The present invention relates to novel markers for alternatively activated macrophages. More specifically, the present invention relates to the use of galactose-type C-type lectins as surface markers that allows rapid identification and sorting of the alternative macrophages. Such identifications can be useful in diseases where there is an imbalance between proinflammatory and anti-inflammatory immune reactions.
    Type: Application
    Filed: March 9, 2006
    Publication date: August 17, 2006
    Applicants: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW, Vrije Universiteit Brussel
    Inventors: Geert Raes, Gholamreza Hassanzadeh Ghassabeh, Patrick Baetselier