Patents by Inventor Geewananda P. Gunawardana

Geewananda P. Gunawardana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal corynecandin
    Patent number: 5863773
    Abstract: Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, whereinR is: ##STR2## --C(O)--R.sub.1 wherein R.sub.1 is alkyl, alkenyl, aryl, arylalkenyl, aryl-aryl-, arylalkoxy-aryl-, aryl-aryl-aryl-, arylkoxy-aryl-aryl-, or ##STR3## wherein R.sub.2 is alkylamino, dialkylamino, (heterocyclic)alkyl, aryl, or arylalkyl; andX is O, NH, or NR.sub.3 wherein R.sub.3 is alkyl or aryl. Also disclosed are pharmaceutical compositions comprising a compound of the invention in combination with a pharmaceutically acceptable carrier; and a process for preparing the compounds of the invention.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: January 26, 1999
    Assignee: Abbott Laboratories
    Inventors: Geewananda P. Gunawardana, David Frost, Marianna Jackson, James P. Karwowski, Ronald R. Rasmussen
  • Process for making taxol derivatives
    Patent number: 5594157
    Abstract: Process of making the compounds having the formula ##STR1## wherein --OR.sup.1 comprises the C-13 side-chain of taxol and R.sup.3 comprises hydrogen.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: January 14, 1997
    Assignee: Abbott Laboratories
    Inventors: Geewananda P. Gunawardana, Larry L. Klein, James B. McAlpine
  • Taxol derivatives
    Patent number: 5530020
    Abstract: Compounds having the formula ##STR1## wherein --OR.sup.1 comprises the C-13 side-chain of taxol and R.sup.3 comprises hydrogen, as well as a method for the preparation thereof.
    Type: Grant
    Filed: October 4, 1994
    Date of Patent: June 25, 1996
    Assignee: Abbott Laboratories
    Inventors: Geewananda P. Gunawardana, Larry L. Klein, James B. McAlpine
  • Taxol derivatives
    Patent number: 5352806
    Abstract: Compounds having the formula ##STR1## wherein --OR.sup.1 comprises the C-13 side-chain of taxol and R.sup.3 comprises hydrogen, as well as a method for the preparation thereof.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: October 4, 1994
    Assignee: Abbott Laboratories
    Inventors: Geewananda P. Gunawardana, Larry L. Klein, James B. McAlpine
  • Bioactive heterocycle alkaloids and methods of use
    Patent number: 5182287
    Abstract: Novel heterocyclic alkaloids were isolated from a marine sponge. These compounds, and derivatives thereof, are useful antifungal and antitumor compounds. The novel compounds have the following structures: ##STR1## wherein R.sub.1 =H, alkyl, alkenyl, aryl, benzyl, acyl, benzoyl, or alkali metal;R.sub.2 and R'.sub.2 =O, S, NOX, or NNHX, wherein X is alkyl or aryl.
    Type: Grant
    Filed: August 20, 1991
    Date of Patent: January 26, 1993
    Assignee: Harbor Branch Oceanographic
    Inventors: Geewananda P. Gunawardana, Peter J. McCarthy, Neal S. Burres
  • Synthesis of compounds with biological activity, and methods of use
    Patent number: 5166379
    Abstract: This invention relates to the methods for the synthesis and use of acetylenic carbinols and their analogs, having various immunomodulatory properties in vitro and in vivo.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: November 24, 1992
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Steve Coval, Gabriel Saucy, Richard D. Wood, Ranjit C. Desai, Geewananda P. Gunawardana, Ross E. Longley, Neal Burres