Patents by Inventor Geir Fonnum

Geir Fonnum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240101999
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: August 17, 2023
    Publication date: March 28, 2024
    Inventors: Thomas POEHMERER, Phillip KUHN, Frank NOTKA, Andreas ZEIDLER, Korbinian HEIL, Axel TREFZER, Geir FONNUM, Federico KATZEN, Kristian ANDERSSON, Xiquan LIANG
  • Patent number: 11851514
    Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: December 26, 2023
    Assignee: Life Technologies AS
    Inventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
  • Publication number: 20230322996
    Abstract: The invention relates to polymer-interaction molecule (e.g., antibodies) conjugates and uses of such conjugates for delivery of interaction molecules to cells. The invention also relates uses polymer-interaction molecule (e.g., antibodies) conjugates for eliciting cellular responses (e.g., induction of cell proliferation).
    Type: Application
    Filed: November 7, 2022
    Publication date: October 12, 2023
    Inventors: Huey Wen OOI, Pontus LUNDBERG, Maxi-Lu BOESCHEN, Hilde ALMAASBAK, Tuva Holt HERENG, Tor Espen STAV-NORAAS, Ole LANDSVERK, Geir FONNUM
  • Publication number: 20230272127
    Abstract: This invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.6; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse coated hydrogel polymer particles.
    Type: Application
    Filed: May 5, 2023
    Publication date: August 31, 2023
    Inventors: Per Nils Pontus Lundberg, Geir Fonnum, Kristian Andersson
  • Patent number: 11680113
    Abstract: This invention relates to monodisperse magnetic hydrogel polymer particles comprising a magnetic material and a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse magnetic hydrogel polymer particles and monodisperse coated polymer particles.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 20, 2023
    Assignee: Life Technologies AS
    Inventors: Per Nils Pontus Lundberg, Geir Fonnum, Kristian Andersson
  • Publication number: 20230167210
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: January 26, 2023
    Publication date: June 1, 2023
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Talha GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Patent number: 11572427
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: February 2, 2021
    Date of Patent: February 7, 2023
    Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, M. Talha Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 11261480
    Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: March 1, 2022
    Assignee: Life Technologies AS
    Inventors: Darren Ellis, Geir Fonnum, Nini Kjus
  • Publication number: 20220056184
    Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
    Type: Application
    Filed: August 27, 2021
    Publication date: February 24, 2022
    Inventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
  • Patent number: 11130833
    Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: September 28, 2021
    Assignee: LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
  • Patent number: 11041068
    Abstract: This invention relates to polymer particles for solid phase oligonucleotide synthesis. The oligonucleotide may be linked to the particle via a linker having an amide-oligoethyleneglycol-amine structure. The particles may be considered to act as a solid support during the oligonucleotide synthesis. Also disclosed are processes for preparing such polymer particles, compositions and systems comprising such particles, and uses thereof.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: June 22, 2021
    Assignees: LIFE TECHNOLOGIES AS, THERMO FISHER SCIENTIFIC GENEART GMBH
    Inventors: Kristian Andersson, Geir Fonnum, Korbinian Heil
  • Publication number: 20210155726
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: February 2, 2021
    Publication date: May 27, 2021
    Inventors: Geir FONNUM, Grete Irene MODAHL, Nini Hofsloekken KJUS, Astrid Evenroed MOLTEBERG, Diem Thuy Thi TRAN, Jo AASERUD, M. Tahla GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20210139626
    Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
    Type: Application
    Filed: October 8, 2020
    Publication date: May 13, 2021
    Inventors: Geir FONNUM, Nils Pontus LUNDBERG, Muhammed Talha GOKMEN, Synne LARSEN, Wilhelm Glomm, Heidi Johnsen, Ruth SCHMID, Lars Kilaas
  • Patent number: 10947333
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: March 16, 2021
    Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Grete Irene Modahl, Nini Hofsloekken Kjus, Astrid Evenroed Molteberg, Diem Thuy Thi Tran, Jo Aaserud, Muhammed Gokmen, Steven M. Menchen, Carl Fuller, Luisa Andruzzi, Wolfgang Hinz
  • Patent number: 10836854
    Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: November 17, 2020
    Assignees: SINTEF, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Nils Pontus Lundberg, Muhammed Talha Gokmen, Synne Larsen, Wilhelm Glomm, Heidi Johnsen, Ruth Schmid, Lars Kilaas
  • Publication number: 20200308630
    Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
    Type: Application
    Filed: April 15, 2020
    Publication date: October 1, 2020
    Inventors: Darren Ellis, Geir Fonnum, Nini Kjus
  • Patent number: 10676790
    Abstract: A polymer substrate, such as a polymer coating or a polymer hydrogel network, includes carboxyl moieties that can be used as conjugation sites to which receptor or analyte molecules can be attached. In an example, the polymer substrate includes a polyacrylamide polymer network having alkanoic acid moieties or derivatives thereof, which can react with carboxyl activating compounds to provide an activated alkanoate moieties on the polyacrylamide network. Amine-terminated nucleic acids can react with the activated alkanoate moieties to capture the nucleic acid to the polymer network through an alkylamide moiety.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: June 9, 2020
    Assignees: LIFE TECHNOLOGIES CORPORATION, LIFE TECHNOLOGIES AS
    Inventors: Geir Fonnum, Steven M. Menchen, Alfred Lui, Guobing Xiang, Synne Larsen
  • Publication number: 20200010827
    Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
    Type: Application
    Filed: July 22, 2019
    Publication date: January 9, 2020
    Inventors: Thomas Poehmerer, Phillip Kuhn, Frank Notka, Andreas Zeidler, Korbinian Heil, Axel Trefzer, Geir Fonnum, Federico Katzen, Kristian Andersson, Xiquan Liang
  • Publication number: 20190390018
    Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
    Type: Application
    Filed: January 21, 2019
    Publication date: December 26, 2019
    Inventors: Geir FONNUM, Steven M. MENCHEN, M. Talha GOKMEN, Pontus LUNDBERG, Prasanna Krishnan THWAR, Alfred LUI, Lily LU, Wolfgang HINZ, Lene HUSABOE, Elisabeth BREIVOLD, Astrid Evenroed MOLTEBERG, Synne LARSEN
  • Publication number: 20190359814
    Abstract: This invention relates to monodisperse magnetic hydrogel polymer particles comprising a magnetic material and a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse coated hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer having a log Poct/wat (log P) of less than about 0.5; and (b) a crosslinker comprising at least two vinyl groups; and a coating. Also provided are methods of forming the monodisperse magnetic hydrogel polymer particles and monodisperse coated polymer particles.
    Type: Application
    Filed: January 19, 2018
    Publication date: November 28, 2019
    Inventors: Per Nils Pontus LUNDBERG, Geir FONNUM, Kristian ANDERSSON