Patents by Inventor Geir Stokke

Geir Stokke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for production of diphtheria toxin
    Patent number: 7575891
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: August 18, 2009
    Assignee: GE Healthcare AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Process for Production of Diphtheria Toxin
    Publication number: 20080153750
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Application
    Filed: September 13, 2007
    Publication date: June 26, 2008
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Process for production diphtheria toxin
    Patent number: 7273728
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, the method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: September 25, 2007
    Assignee: GE Healthcare AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Process for production diphtheria toxin
    Publication number: 20060035340
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Application
    Filed: August 15, 2005
    Publication date: February 16, 2006
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Process for production diphtheria toxin
    Patent number: 6962803
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: November 8, 2005
    Assignee: Amersham Health AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Process for production diphtheria toxin
    Publication number: 20040087775
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Application
    Filed: October 22, 2003
    Publication date: May 6, 2004
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust
  • Process for production diphtheria toxin
    Patent number: 6689871
    Abstract: The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, the method comprising adding glucose to a growing culture whereby the addition of glucose maintains microorganism growth effective to support diphtheria toxin production; and (2) purifying the diphtheria toxin from the culture by contacting a toxin containing preparation derived therefrom with an ion exchange matrix, eluting a fraction containing the toxin, applying the eluate to a hydrophobic matrix, and eluting a fraction containing the toxin.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: February 10, 2004
    Assignee: Amersham Health AS
    Inventors: Henry Wolfe, Fahar Merchant, Rosemina Merchant, Christopher Black, Harry Storflor, Geir Stokke, Halldis Hellebust