Patents by Inventor Gemma Zuend

Gemma Zuend has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2?-deoxy-2?,2?-difluorotetrahydrouridines with high purity and methods of making the same
    Patent number: 12195496
    Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
    Type: Grant
    Filed: April 28, 2023
    Date of Patent: January 14, 2025
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Gemma Zuend, Ian Scott, Nipun Davar, Kimiyoshi Annaka, Masahiro Miyake, Motoshi Matsui
  • 2?-deoxy-2?,2?-difluorotetrahydrouridines with high purity and methods of making the same
    Patent number: 12187757
    Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: January 7, 2025
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Gemma Zuend, Ian Scott, Nipun Davar, Kimiyoshi Annaka, Masahiro Miyake, Motoshi Matsui
  • 2?-DEOXY-2?,2?-DIFLUOROTETRAHYDROURIDINES WITH HIGH PURITY AND METHODS OF MAKING THE SAME
    Publication number: 20230303609
    Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
    Type: Application
    Filed: April 28, 2023
    Publication date: September 28, 2023
    Inventors: Gemma Zuend, Ian Scott, Nipun Davar, Kimiyoshi Anaka, Masahiro Miyake, Motoshi Matsui
  • 2'-DEOXY-2',2'-DIFLUOROTETRAHYDROURIDINES WITH HIGH PURITY AND METHODS OF MAKING THE SAME
    Publication number: 20220411457
    Abstract: The invention relates to methods of synthesizing 2?-deoxy-2?,2?-difluorotetrahydrouridine with increased purity and uniform particle size distribution. In particular, methods of the invention include crystallization and isolation procedures rendering synthetic reaction intermediates. The invention further includes compositions comprising the final compound in highly pure form, including lower number of impurities and lower levels of individual and total impurities.
    Type: Application
    Filed: October 7, 2020
    Publication date: December 29, 2022
    Inventors: Gemma Zuend, Ian Scott, Nipun Davar, Kimiyoshi Anaka, Masahiro Miyake, Motoshi Matsui