Patents by Inventor Gen Sheng Wu

Gen Sheng Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20220288079
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: March 21, 2022
    Publication date: September 15, 2022
    Applicant: The Penn State Research Foundation
    Inventors: Joshua E. ALLEN, Gen Sheng WU, Wafik S. EL-DEIRY
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20170224690
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: April 23, 2017
    Publication date: August 10, 2017
    Applicant: The Penn State Research Foundation
    Inventors: Joshua E. ALLEN, Gen Sheng WU, Wafik S. EL-DEIRY
  • Small molecule TRAIL gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9629842
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: April 25, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20170000790
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: September 19, 2016
    Publication date: January 5, 2017
    Applicant: The Penn State Research Foundation
    Inventors: Wafik S. EL-DEIRY, Joshua E. ALLEN, Gen Sheng WU
  • Small molecule TRAIL gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9452165
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 27, 2016
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20150265619
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 24, 2015
    Applicant: The Penn State Research Foundation
    Inventors: Wafik S. EL-DEIRY, Joshua E. Allen, Gen Sheng Wu
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20150202206
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: July 22, 2014
    Publication date: July 23, 2015
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng WU
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9072744
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: July 7, 2015
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9061032
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: June 23, 2015
    Assignee: The Penn State Research Foundation
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20140248264
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: February 27, 2014
    Publication date: September 4, 2014
    Applicant: The Penn State Research Foundation
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • VACCINES TARGETING CELLULAR DEATH RECEPTORS
    Publication number: 20140205538
    Abstract: The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.
    Type: Application
    Filed: January 15, 2014
    Publication date: July 24, 2014
    Applicant: Wayne State University
    Inventors: Wei-Zen Wei, Gen Sheng Wu, Marie P. Piechocki, Richard F. Jones
  • Vaccine targeting cellular death receptor DR5
    Patent number: 8685939
    Abstract: The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.
    Type: Grant
    Filed: November 6, 2009
    Date of Patent: April 1, 2014
    Assignee: Wayne State University
    Inventors: Wei-Zen Wei, Gen Sheng Wu, Marie P. Piechocki, Richard F. Jones
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 8673923
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: March 18, 2014
    Assignee: The Penn State Research Foundation
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20120276088
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 1, 2012
    Applicant: The Penn State Research Foundation
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • VACCINES TARGETING CELLULAR DEATH RECEPTORS
    Publication number: 20120189572
    Abstract: The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within the host's body. The therapeutics are vaccine compositions, including genetic vaccines encoding death receptor antigens of the tumor necrosis factor receptor family. Also provided are means and methods for overcoming host immunological tolerance to death receptors. The vaccines are useful against cancer cells and other death receptor bearing target cells within the host, and can be used in both therapeutic and prophylactic settings. The vaccines are also useful for diagnostic testing of the immunocompetence of a host.
    Type: Application
    Filed: November 6, 2009
    Publication date: July 26, 2012
    Inventors: Wei-Zen Wei, Gen Sheng Wu, Marie P. Piechocki, Richard F. Jones
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: RE46290
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 31, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu