Patents by Inventor Gen TAKEBE
Gen TAKEBE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180236257Abstract: A cell stimulation method includes continuously emitting mid-infrared light to a living cell and thus changing an ion concentration of the cell or changing ion concentrations of the cell and other cells disposed around the cell.Type: ApplicationFiled: February 14, 2018Publication date: August 23, 2018Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Gen TAKEBE, Yoshiyuki SHIMIZU, Toyohiko YAMAUCHI, Tatsuo DOUGAKIUCHI
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Patent number: 9168504Abstract: A microparticle dispersion liquid manufacturing apparatus 10 includes a controller 11, a light source 12, an irradiation optical system 13, and a container 14. A solid object 1 is contained in and a solvent 2 is injected into an interior of the container 14 to enable attainment of a state where the solid object 1 is in contact with the solvent 2. The light source 12 repeatedly outputs pulsed light. By repeatedly irradiating the solvent 2 with the pulsed light from the light source 12, expansion and contraction of the solvent 2 is made to occur repeatedly at the irradiated portion, thereby generating a pressure wave in the solvent 2, and the pressure wave is made to act on the solid object 1 to finely pulverize the solid object 1 and thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent.Type: GrantFiled: March 10, 2011Date of Patent: October 27, 2015Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Tokio Takagi, Mitsuo Hiramatsu, Gen Takebe, Naota Akikusa, Kazuue Fujita, Tatsuo Dougakiuchi
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Patent number: 9157851Abstract: The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.Type: GrantFiled: January 16, 2013Date of Patent: October 13, 2015Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Gen Takebe, Yoichi Kawada, Kouichiro Akiyama
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Patent number: 9128041Abstract: The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.Type: GrantFiled: January 16, 2013Date of Patent: September 8, 2015Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Gen Takebe, Yoichi Kawada, Kouichiro Akiyama
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Patent number: 8663702Abstract: A method and an apparatus enabling manufacture of a microparticle dispersion liquid at high efficiency in a short time while suppressing drug degradation, etc., are provided. In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent in a container 13. In a fixing step following the dissolving step, the organic solvent, contained in a solution, is eliminated by evaporation, a pellet-form residue 1 is obtained by the organic solvent elimination, and the residue 1 is fixed on an inner wall of the container 13. In a water injecting step following the fixing step, water 2 is injected into an interior of the container 13.Type: GrantFiled: March 19, 2007Date of Patent: March 4, 2014Assignee: Hamamatsu Photonics K.K.Inventors: Gen Takebe, Tomonori Kawakami, Tokio Takagi, Mitsuo Hiramatsu
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Patent number: 8563044Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.Type: GrantFiled: August 1, 2011Date of Patent: October 22, 2013Assignee: Hamamatsu Photonics K.K.Inventors: Gen Takebe, Tokio Takagi, Mitsuo Hiramatsu
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Patent number: 8445019Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.Type: GrantFiled: September 23, 2008Date of Patent: May 21, 2013Assignee: Hamamatsu Photonics K.K.Inventors: Gen Takebe, Tokio Takagi, Mitsuo Hiramatsu
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Publication number: 20130056565Abstract: A microparticle dispersion liquid manufacturing apparatus 10 includes a controller 11, a light source 12, an irradiation optical system 13, and a container 14. A solid object 1 is contained in and a solvent 2 is injected into an interior of the container 14 to enable attainment of a state where the solid object 1 is in contact with the solvent 2. The light source 12 repeatedly outputs pulsed light. By repeatedly irradiating the solvent 2 with the pulsed light from the light source 12, expansion and contraction of the solvent 2 is made to occur repeatedly at the irradiated portion, thereby generating a pressure wave in the solvent 2, and the pressure wave is made to act on the solid object 1 to finely pulverize the solid object 1 and thereby manufacture a microparticle dispersion liquid in which microparticles are dispersed in the solvent.Type: ApplicationFiled: March 10, 2011Publication date: March 7, 2013Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Tokio Takagi, Mitsuo Hiramatsu, Gen Takebe, Naota Akikusa, Kazuue Fujita, Tatsuo Dougakiuchi
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Publication number: 20120328480Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues are obtained by the organic solvent removal, and the residues are fixed on respective bottom surfaces of a plurality of locations of a container. In a water injecting step, water is injected into each of a plurality of recesses of the container. In an irradiating step, laser light L, emitted from a light irradiating unit, is irradiated simultaneously or successively on the residues fixed on the respective bottom surfaces of the recesses of the container, and the residues are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water, is manufactured.Type: ApplicationFiled: December 21, 2011Publication date: December 27, 2012Inventors: Gen Takebe, Tokio Takagi, Mitsuo Hiramatsu
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Publication number: 20110306564Abstract: In a dissolving step, in a container 13, a poorly soluble drug and a dispersion stabilizer (polyvinylpyrrolidone and sodium lauryl sulfate) are dissolved in a volatile organic solvent. In a solid composition forming step following the dissolving step, the organic solvent contained in the solution is removed by evaporation, and by the organic solvent removal, a solid composition 1 is obtained as a residue, and the solid composition 1 becomes fixed on the inner wall of the container 13. In a water injecting step following the solid composition forming step, water 2 is injected into the interior of the container 13. In a microparticle dispersion liquid preparing step following the water injecting step, laser light L emitted from a laser light source 11 is irradiated on the solid composition 1 fixed on the inner wall of the container 13 and optical energy is thereby applied to the solid composition 1.Type: ApplicationFiled: August 25, 2011Publication date: December 15, 2011Inventors: Gen Takebe, Mitsuo Hiramatsu, Tokio Takagi
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Publication number: 20110285043Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.Type: ApplicationFiled: August 1, 2011Publication date: November 24, 2011Inventors: Gen TAKEBE, Tokio Takagi, Mitsuo Hiramatsu
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Publication number: 20090142402Abstract: A method and an apparatus enabling manufacture of a microparticle dispersion liquid at high efficiency in a short time while suppressing drug degradation, etc., are provided. In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent in a container 13. In a fixing step following the dissolving step, the organic solvent, contained in a solution, is eliminated by evaporation, a pellet-form residue 1 is obtained by the organic solvent elimination, and the residue 1 is fixed on an inner wall of the container 13. In a water injecting step following the fixing step, water 2 is injected into an interior of the container 13.Type: ApplicationFiled: March 19, 2007Publication date: June 4, 2009Inventors: Gen Takebe, Tomonori Kawakami, Tokio Takagi, Mitsuo Hiramatsu
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Publication number: 20090087460Abstract: In a dissolving step, in a container 13, a poorly soluble drug and a dispersion stabilizer (polyvinylpyrrolidone and sodium lauryl sulfate) are dissolved in a volatile organic solvent. In a solid composition forming step following the dissolving step, the organic solvent contained in the solution is removed by evaporation, and by the organic solvent removal, a solid composition 1 is obtained as a residue, and the solid composition 1 becomes fixed on the inner wall of the container 13. In a water injecting step following the solid composition forming step, water 2 is injected into the interior of the container 13. In a microparticle dispersion liquid preparing step following the water injecting step, laser light L emitted from a laser light source 11 is irradiated on the solid composition 1 fixed on the inner wall of the container 13 and optical energy is thereby applied to the solid composition 1.Type: ApplicationFiled: September 23, 2008Publication date: April 2, 2009Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Gen Takebe, Mitsuo Hiramatsu, Tokio Takagi
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Publication number: 20090081301Abstract: In a dissolving step, a poorly soluble drug and a dispersion stabilizer are dissolved in a volatile organic solvent. In a fixing step, the organic solvent, contained in a solution obtained in the dissolving step, is removed by evaporation, pellet-form residues 1 are obtained by the organic solvent removal, and the residues 1 are fixed on respective bottom surfaces of a plurality of locations of a container 30. In a water injecting step, water 2 is injected into each of a plurality of recesses 31 of the container 30. In an irradiating step, laser light L, emitted from a light irradiating unit 20, is irradiated simultaneously or successively on the residues 1 fixed on the respective bottom surfaces of the recesses 31 of the container 30, and the residues 1 are thereby pulverized and made into microparticles and a microparticle dispersion liquid, constituted of the microparticles being dispersed in the water 2, is manufactured.Type: ApplicationFiled: September 23, 2008Publication date: March 26, 2009Applicant: HAMAMATSU PHOTONICS K.K.Inventors: Gen TAKEBE, Tokio Takagi, Mitsuo Hiramatsu