Patent number: 6716850
Abstract: Compounds of the formula I:
where;
R1 is O, S;
R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond;
R3 is H, C1-C3 alkyl,
R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto;
X is —(CHR8)n-—D—(CHR8)m—;
D is —NR9—, —O—, —S—, —S(═O)— or —S(═O)2—;
R8 is independently H, C1-C3 alkyl, halo substitutedC1-C3alkyl;
R9 is H, C1-C3 alkyl;
n and m are independently 0, 1 or 2;
and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particular
Type:
Grant
Filed:
March 5, 2002
Date of Patent:
April 6, 2004
Assignee:
Medivir AB
Inventors:
Stefan Lindström, Christer Sahlberg, Hans Wallberg, Genaidy Kalyanov, Lourdes Salvador Odén, Lotta Naeslund
