Patents by Inventor Gene H. Zaid

Gene H. Zaid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HARMINE SYNTHESIS
    Publication number: 20220064156
    Abstract: Methods for the synthesis of harmine comprise reacting harmaline with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in the presence of a diacid catalyst. In an embodiment, the synthesis is carried out using a reaction mixture of harmaline, DDQ, THF solvent, and succinic acid; the reaction is carried out under an inert atmosphere with refluxing for a period of 4-12 hours.
    Type: Application
    Filed: September 1, 2020
    Publication date: March 3, 2022
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Krishna Mohan Donavalli, Rajni Verma
  • INHIBITION OF DYRK1A KINASE
    Publication number: 20220064091
    Abstract: Novel compounds which inhibit DYRK1A activity comprise thymoquinone derivatives including a pair of substituted or unsubstituted six-membered carbon rings selected from phenyl and cyclohexadiene linked by an alkyl or alkenyl linker. Each six-membered ring includes at least one oxygen-bearing substituent selected from carbonyl oxygens, hydroxyls, alkoxyls, and halogenated derivatives thereof. The compounds can be administered to mammalian subjects for inhibition of DYRK1A kinase proteins.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 3, 2022
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Brian Scott Johnathan Blagg, Cameron E. West
  • Nutritional supplement for mammals
    Patent number: 11246902
    Abstract: Mammalian nutritional supplements comprising individual quantities of turmeric, Peganum harmala, and Arum palaestinum are provided, which promote several aspects of human health, and canine health. Advantageously, the turmeric is present in an amount greater than that of Peganum harmala or Arum palaestinum, and the supplements may contain additional beneficial ingredients, such as ?-sitosterol, vanillin, garlic, and Vitamin C.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: February 15, 2022
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Beth Ann Wolf, Larry D. Crow, Robert Preston Moore, Rachel Elizabeth Ropp
  • THERAPEUTIC AGENTS AND USES THEREOF
    Publication number: 20220033417
    Abstract: Human therapeutic compositions are provided, comprising compounds including a plurality of fused polycyclic moieties and a linker moiety. In certain embodiments, the compounds are the reaction products of aldehyde and harmaline components. The compositions exhibit anti-cancer properties, especially against lymphoma, leukemia, pancreatic, endometrial, ovarian, gastric, breast, renal, cervical, head and neck, and myeloma cell lines.
    Type: Application
    Filed: December 1, 2020
    Publication date: February 3, 2022
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne
  • COMBINATION ANTI-CANCER PRODUCTS AND METHODS
    Publication number: 20220008359
    Abstract: Combination dosage forms of anti-cancer products include components a) and b), where component a) comprises individual amounts of curcumin, harmine, isovanillin, and component b) comprises an agent selected from the group consisting of EGFR inhibitors, CDK 4/6 inhibitors, 5-fluorouracil, checkpoint inhibitors, anti-metabolites, prodrugs thereof, and mixtures thereof. The products may be administered to mammalian subjects suffering from a variety of cancers, to provide a synergistic therapeutic effect.
    Type: Application
    Filed: July 8, 2021
    Publication date: January 13, 2022
    Inventors: Gene H. Zaid, Cameron E. West, Robert Preston Moore, Paul Dent
  • LOW-TEMPERATURE SYNTHESIS OF THYMOQUINONE AND HARMALINE COMPOUNDS
    Publication number: 20210276998
    Abstract: Low-temperature syntheses of thymoquinone/harmaline compounds are provided which give increased yields of desirable products having molecular weights of from about 360-380. The syntheses involve carrying out reactions between thymoquinone and harmaline and a non-interfering solvent at a temperature of less than about 10° C.
    Type: Application
    Filed: March 5, 2020
    Publication date: September 9, 2021
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Beth Ann Wolf, Rachel Elizabeth Ropp
  • Fused polycyclic dimers
    Patent number: 10947253
    Abstract: Novel fused tricyclic or bicyclic dimers, such as ?-carboline and quinoline moieties with a central linker, exhibit anti-cancer activities against a variety of human cancer cell lines. The dimer compounds can be used in anti-cancer therapeutic compositions useful in the treatment of human cancers.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: March 16, 2021
    Assignee: Ankh Life Sciences Limited
    Inventors: Brian Scott Johnathan Blagg, Vishal Chandrakumar Birar, Gene H. Zaid
  • FUSED POLYCYCLIC DIMERS
    Publication number: 20210040121
    Abstract: Novel fused tricyclic or bicyclic dimers, such as ?-carboline and quinoline moieties with a central linker, exhibit anti-cancer activities against a variety of human cancer cell lines. The dimer compounds can be used in anti-cancer therapeutic compositions useful in the treatment of human cancers.
    Type: Application
    Filed: August 5, 2019
    Publication date: February 11, 2021
    Applicant: Ankh Life Sciences Limited
    Inventors: Brian Scott Johnathan Blagg, Vishal Chandrakumar Birar, Gene H. Zaid
  • Thymoquinone/harmaline and related reaction products
    Patent number: 10875859
    Abstract: New compositions of matter useful for the treatment of human diabetes and cancers comprise the reaction products of thymoquinone and harmaline or harmaline-like compounds, such as ?-carboline compounds, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: December 29, 2020
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Cameron E. West
  • HUMAN THERAPEUTIC AGENTS
    Publication number: 20200383958
    Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
    Type: Application
    Filed: August 21, 2020
    Publication date: December 10, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne
  • TOPICAL MEDICAMENTS
    Publication number: 20200330372
    Abstract: Topical medicaments for the treatment of mammalian skin are provided, which include an actives fraction and a carrier fraction; the actives fraction comprises individual amounts of turmeric, Peganum harmala, and Arum palaestinum. In other embodiments, the actives fraction includes additional ingredients, including Vitamin C, ?-sitosterol, and vanillin compound(s). The medicaments are useful in the treatment of a wide variety of conditions.
    Type: Application
    Filed: April 20, 2020
    Publication date: October 22, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Beth Ann Wolf, Robert Preston Moore, Rachel Elizabeth Ropp
  • Nutritional supplement
    Patent number: 10772347
    Abstract: Nutritional supplements comprising individual quantities of turmeric, Peganum harmala, and Arum palaestinum are provided, which promote several aspects of human health. Advantageously, the turmeric is present in an amount greater than that of Peganum harmala or Arum palaestinum, and the supplements may contain additional beneficial ingredients, such as ?-sitosterol, vanillin, garlic, and Vitamin C.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: September 15, 2020
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Beth Ann Wolf, Larry D. Crow
  • Human therapeutic agents
    Patent number: 10751330
    Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 25, 2020
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne
  • Human therapeutic agents
    Patent number: 10744124
    Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: August 18, 2020
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne
  • HUMAN THERAPEUTIC AGENTS
    Publication number: 20200147061
    Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
    Type: Application
    Filed: December 23, 2019
    Publication date: May 14, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne
  • HUMAN THERAPEUTIC AGENTS
    Publication number: 20200121654
    Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
    Type: Application
    Filed: December 23, 2019
    Publication date: April 23, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne
  • THYMOQUINONE/HARMALINE AND RELATED REACTION PRODUCTS
    Publication number: 20200102306
    Abstract: New compositions of matter useful for the treatment of human diabetes and cancers comprise the reaction products of thymoquinone and harmaline or harmaline-like compounds, such as ?-carboline compounds, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.
    Type: Application
    Filed: December 3, 2019
    Publication date: April 2, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Cameron E. West
  • THYMOQUINONE/HARMALINE AND RELATED REACTION PRODUCTS
    Publication number: 20200101050
    Abstract: New compositions of matter useful for the treatment of human diabetes and cancers comprise the reaction products of thymoquinone and harmaline or harmaline-like compounds, such as ?-carboline compounds, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.
    Type: Application
    Filed: December 3, 2019
    Publication date: April 2, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Cameron E. West
  • THYMOQUINONE/HARMALINE AND RELATED REACTION PRODUCTS
    Publication number: 20200102305
    Abstract: New compositions of matter useful for the treatment of human diabetes and cancers comprise the reaction products of thymoquinone and harmaline or harmaline-like compounds, such as ?-carboline compounds, and the derivatives, solvates, prodrugs, isomers, and tautomers of such compounds.
    Type: Application
    Filed: December 3, 2019
    Publication date: April 2, 2020
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Cameron E. West
  • Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
    Patent number: 10576067
    Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: March 3, 2020
    Assignee: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Thomas W. Burgoyne