Patents by Inventor Gene Michal
Gene Michal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230149676Abstract: In an example, a bioresorbable implant for use in a nasal region includes one or more bioresorbable polymers, and a pharmaceutical composition coupled to the one or more bioresorbable polymers. A release rate of the pharmaceutical composition is related to a degradation rate of the one or more bioresorbable polymers.Type: ApplicationFiled: January 19, 2023Publication date: May 18, 2023Inventors: Gene Michal, Daniel L. Cox, Piyush Arora, Michael S. Mirizzi, Scott Baron
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Patent number: 11590329Abstract: In another example, a bioresorbable implant for use in a nasal region includes one or more bioresorbable polymers, and a pharmaceutical composition coupled to the one or more bioresorbable polymers. A release rate of the pharmaceutical composition is related to a degradation rate of the one or more bioresorbable polymers.Type: GrantFiled: May 16, 2019Date of Patent: February 28, 2023Assignee: Spirox, Inc.Inventors: Gene Michal, Daniel L. Cox, Piyush Arora, Michael S. Mirizzi, Scott Baron
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Publication number: 20190358439Abstract: In another example, a bioresorbable implant for use in a nasal region includes one or more bioresorbable polymers, and a pharmaceutical composition coupled to the one or more bioresorbable polymers. A release rate of the pharmaceutical composition is related to a degradation rate of the one or more bioresorbable polymers.Type: ApplicationFiled: May 16, 2019Publication date: November 28, 2019Inventors: Gene Michal, Daniel L. Cox, Piyush Arora, Michael S. Mirizzi, Scott Baron
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Publication number: 20140348800Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.Type: ApplicationFiled: May 29, 2014Publication date: November 27, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Gene Michal, Shubhayu Basu
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Patent number: 8828433Abstract: Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1-lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1-lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PR11, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors.Type: GrantFiled: April 19, 2005Date of Patent: September 9, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Charles Claude, Connie Kwok, Gene Michal, Jihong Qu, Sophia Liao
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Patent number: 8828436Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: GrantFiled: May 6, 2013Date of Patent: September 9, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Patent number: 8741326Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.Type: GrantFiled: November 17, 2006Date of Patent: June 3, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Gene Michal, Shubhayu Basu
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Patent number: 8708948Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.Type: GrantFiled: February 21, 2012Date of Patent: April 29, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Paul Consigny, Gabriel Asongwe, Mary Beth Michaels, Gene Michal, Evgenia Mandrusov, Jeong Lee, Florian N. Ludwig, John Eric Henckel, Joseph J. Sciacca, Ken Bueche, Richard Todd Thornton, Fidel Albert Urrabazo, Daniel Wiegand
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Patent number: 8697058Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.Type: GrantFiled: September 20, 2012Date of Patent: April 15, 2014Assignee: Abott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Gene Michal, Florian N. Ludwig, Jinping Wan, John Stankus
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Publication number: 20130251764Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: ApplicationFiled: May 6, 2013Publication date: September 26, 2013Applicant: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Patent number: 8465773Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: GrantFiled: May 15, 2012Date of Patent: June 18, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Patent number: 8465772Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: GrantFiled: May 15, 2012Date of Patent: June 18, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Patent number: 8388948Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.Type: GrantFiled: June 15, 2012Date of Patent: March 5, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Gene Michal, Florian Ludwig, Jinping Wan, John Stankus
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Patent number: 8293226Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.Type: GrantFiled: June 15, 2012Date of Patent: October 23, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Gene Michal, Florian Ludwig, Jinping Wan, John Stankus
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Publication number: 20120252089Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.Type: ApplicationFiled: June 15, 2012Publication date: October 4, 2012Applicant: Abbott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Gene Michal, Florian Ludwig, Jingping Wan, John Stankus
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Publication number: 20120251508Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.Type: ApplicationFiled: June 15, 2012Publication date: October 4, 2012Applicant: Abbott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Gene Michal, Florian Ludwig, Jinping Wan, John Stankus
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Publication number: 20120225041Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: ApplicationFiled: May 15, 2012Publication date: September 6, 2012Applicant: Abbott Cardiovascular System Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Publication number: 20120225040Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.Type: ApplicationFiled: May 15, 2012Publication date: September 6, 2012Applicant: Abbott Cardiovascular Systems Inc.Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
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Patent number: 8221744Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.Type: GrantFiled: September 19, 2007Date of Patent: July 17, 2012Assignee: Abbott Cardiovascular Systems Inc.Inventors: Shubhayu Basu, Gene Michal, Florian Ludwig, Jinping Wan, John Stankus
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Publication number: 20120157751Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.Type: ApplicationFiled: February 21, 2012Publication date: June 21, 2012Applicant: ADVANCED CARDIOVASCULAR SYSTEMS INC.Inventors: Paul Consigny, Gabriel Asongwe, Mary Beth Michaels, Gene Michal, Evgenia Mandrusov, Jeong Lee, Florian Ludwig, John Eric Henckel, Joseph J. Sciacca, Ken Bueche, Richard Todd Thornton, Fidel Albert Urrabazo, Daniel Wiegand