Patents by Inventor Gene W. Holbert

Gene W. Holbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treatment using 18-cyanoprogesterone derivatives
    Patent number: 4954491
    Abstract: The present invention is directed to a method for the treatment of hyperaldosteronism and related disorders which comprises administering to an appropriate patient an appropriate 18-cyanopregnane.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: September 4, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. O'Neal Johnston, Gene W. Holbert
  • 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors
    Patent number: 4920114
    Abstract: 19-Fluoro- and cyano- substituted 21-hydroxyprogesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: April 24, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gene W. Holbert, J. O'Neal Johnston
  • 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
    Patent number: 4910191
    Abstract: 19-Substituted progesterone derivatives and related compounds which are active as 19-hydroxylase inhibitors and useful as antihypertensive agents are described herein. The compounds are prepared using appropriate synthetic pathways which will vary according to the nature of the specific 19-substituted progesterone or related compound desired.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: March 20, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Gene W. Holbert, J. O'Neal Johnston
  • 3.beta.,17.beta.-hydroxy-substituted steroids and related steroidal compounds
    Patent number: 4882322
    Abstract: The present invention is directed to a group of compounds which are 3.beta.,17.beta.-hydroxy steriods, and related steroidal structures. These compounds are armatase inhibitors, and thus, regulate or inhibit the conversion of androgens to estrogens. These compounds may be utilized to treat conditions potentiated by the presence of estrogens. These compounds exhibit a slower onset of action and a longer half life relative to the 10-(2-alkynyl) steroidal aromatase inhibitors disclosed in U.S. Pat. No. 4,322,416.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: November 21, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. O'Neal Johnston, Gene W. Holbert
  • Synthesis for the preparation of 4-amino-4,5-dihydro-2-furancarboxylic acid
    Patent number: 4824974
    Abstract: This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C.sub.1-6 lower alkyl esters thereof. These compounds are .gamma.-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.
    Type: Grant
    Filed: October 15, 1987
    Date of Patent: April 25, 1989
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Joseph P. Burkhart, Gene W. Holbert
  • Intermediates for the synthesis of 4-amino-4,5-dihydro-2-furancarboxylic acid
    Patent number: 4588825
    Abstract: This application relates to a stereospecific process for preparing specific enantiomers of 4-amino-4,5-dihydro-2-furancarboxylic acid and C.sub.1-6 lower alkyl esters thereof. These compounds are .gamma.-aminobutyric acid transaminase inhibitors useful in the treatment of epilepsy.
    Type: Grant
    Filed: March 13, 1985
    Date of Patent: May 13, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Joseph P. Burkhart, Gene W. Holbert