Patents by Inventor Genevève Courtois

Genevève Courtois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for the treatment of myelodysplastic syndromes
    Patent number: 9675590
    Abstract: The present invention provides methods and pharmaceutical compositions designed to intervene in this defective process and to promote or restore erythrocyte maturation in individuals suffering from a myelodysplastic syndrome. The methods involve maintaining the activity of GATA-1 by preventing sequestration of Hsp70 in the cytoplasm. Accordingly, it is an object of this invention to provide methods of restoring or increasing erythrocyte maturation in a subject suffering from a myelodysplastic syndrome by preventing proteolytic inactivation of GATA-1. In some embodiments, preventing is achieved by administering to the subject a compound that inhibits the XPO1 nuclear transporter.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: June 13, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Fondation Imagine, Assistance Publique-Hopitaux de Paris (APHP), Universite Paris Descartes, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Olivier Hermine, Flavia Guillem, Jean-Benoit Arlet, Genevève Courtois, Michaela Fontenay