Patents by Inventor Geng-tao Liu

Geng-tao Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DDB as an agent against BEL-7402 human hepatocarcinoma
    Patent number: 5155111
    Abstract: Dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxyla te (DDB), a synthetic analogue of Schizandrin C, is a useful chemotherapeutic agent for the treatment of BEL-7402 human hepatocarcinoma when used in combination with 6-mercaptopurine.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: October 13, 1992
    Assignee: Institute of Materia Medica
    Inventor: Geng-Tao Liu
  • Process for the preparation of clausenamide and neoclausenamide, and derivatives thereof
    Patent number: 5132433
    Abstract: A process for the preparation of compound of the formula ##STR1## in which R.sup.1 --represents ##STR2## and R.sup.2 --represents hydrogen, fluorine, chlorine or bromine. Comprising cyclizing compounds of the formula ##STR3## and, in a further step, either a) reducing stereo-specifically to give compounds of the formula in which R.sup.1 represents ##STR4## or b), to give compounds of the formula in which R.sup.1 represents ##STR5## or by c) forming compounds of the formula ##STR6## followed by stereoselective reduction to give compounds in which R.sup.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: July 21, 1992
    Assignees: Bayer Aktiengesellschaft, Chinese Academy of Medical Sciences
    Inventors: Liang Huang, Geng-tao Liu
  • Dehydrocycloclausenamide, its preparation and use in treating cerebral hypoxia
    Patent number: 5093350
    Abstract: Processes for the preparation of compounds of the formula ##STR1## in which R and R.sup.1 are identical or different and represent hydrogen or halogen, in the racemic form or in the form of its pure enantiomers by cyclicizing compounds of the formula ##STR2## with 2,6-lutidine or by cyclicizing compounds of the formula ##STR3## with diethyl azodicarboxylate. Compounds where R is halogen are new and are useful as cerebral therapeutics, nootropics or in the reduction of increased glutamine pyruvate transaminase in serum.
    Type: Grant
    Filed: July 30, 1990
    Date of Patent: March 3, 1992
    Assignees: Bayer Aktiengesellschaft, Chinese Academy of Medical Sciences
    Inventors: Liang Huang, Geng-tao Liu
  • N-substituted amide derivatives useful for treating liver diseases
    Patent number: 4937360
    Abstract: N-substituted amide derivative represented by the formula ##STR1## wherein A is --CH(OH)-- or --C(.dbd.O)--, R.sup.1 is a hydrogen atom or an lkyl group having 1 to 3 carbon atoms, and R.sup.2 is an alkyl group having 1 to 6 carbon atoms, are disclosed. These compounds are useful for prevention and therapy for liver diseases.
    Type: Grant
    Filed: June 28, 1989
    Date of Patent: June 26, 1990
    Assignees: Taisho Pharmaceutical Co., Ltd., The Institute of Materia Medica of Chinese Academy of Medical Sciences
    Inventors: Geng-tao Liu, Liang Huang, Er-chang Rao, Jin Zhou, Yan Li, Katsuo Hatayama, Tatsuhiko Sano, Kensei Yoshikawa, Shohei Higuchi, Iwao Arai
  • Pharmacologically active .epsilon.-valerolactams
    Patent number: 4927937
    Abstract: A pharmacologically active .epsilon.-valerolactam has been isolated from the leaves of Clausena lansium. This compound and its derivatives have the formula ##STR1## where R is hydrogen or a C.sub.1 -C.sub.18 -acyl group. It has been found that these compounds are useful in the treatment of hypoxia and as antiamonestics.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: May 22, 1990
    Assignees: Chinese Academy of Medical Science, Bayer Aktiengesellschaft
    Inventors: Ming-he Yang, Yan-rong Chen, Geng-tao Liu, Liang Huang
  • Delta-butyrolactams, thereof, processes for the preparation thereof and their medical use
    Patent number: 4879390
    Abstract: Purified Clausenamide of the formula ##STR1## is obtained by extraction of leaves of Clausena lansium followed by purification, Reduction products, ethers, etc. can be produced. The compounds are effective in treating hypoxia and amnesia.
    Type: Grant
    Filed: April 27, 1988
    Date of Patent: November 7, 1989
    Assignees: Chinese Academy of Medical Sciences, Bayer Aktiengesellschaft
    Inventors: Yen-rong Chen, Ming-he Yang, Liang Huang, Geng-tao Liu, Ulrich Benz
  • 2,3-dihydroxy-3-phenyl-N-(2-phenyl-ethyl)-propionic acid amides derivatives thereof
    Patent number: 4826873
    Abstract: Compounds of the general formula ##STR1## wherein R.sub.1 represents hydrogen, an acyl group having 1 to 18 carbon atoms or both R.sub.1 together the group ##STR2## R.sub.2 represents hydrogen or a methyl group, have been isolated in small amounts from the leaves of Clausena lansium. The new compounds are to be used for the production of compositions for the use of the treatment of acute and chronical viral hepatitis, liver intoxication, hypoxia or amnesia.
    Type: Grant
    Filed: January 15, 1987
    Date of Patent: May 2, 1989
    Assignees: Chinese Academy of Medical Sciences, Bayer Aktiengesellschaft
    Inventors: Ming-he Yang, Yan-rong Chen, Geng-tao Liu, Liang Huang
  • Pharmacologically active bicyclic lactams
    Patent number: 4757064
    Abstract: A pharmacologically active phenyl-substituted bicyclic lactam has been isolated from the leaves of Clausena lansium. This compound and its derivatives have the formula ##STR1## Where R is hydrogen of a C.sub.1 -C.sub.18 -acyl group. It has been found that these compounds are useful in the treatment of hypoxia and as antiamnestics.
    Type: Grant
    Filed: January 20, 1987
    Date of Patent: July 12, 1988
    Assignees: Bayer Aktiengesellschaft, Chinese Academy of Medical Sciences
    Inventors: Ming-he Yang, Yan-rong Chen, Geng-tao Liu, Liang Huang