Patents by Inventor Genghao Chen

Genghao Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA AND DNA BASE EDITING VIA ENGINEERED ADAR RECRUITMENT
    Publication number: 20220010333
    Abstract: Disclosed herein is a system to recruit ADARs to catalyze therapeutic editing of point mutations via the use of engineered RNA scaffolds, engineered DNA scaffolds or DNA-RNA hybrid scaffolds. The system comprises an engineered ADAR2 guide RNA (adRNA) that bears a 20-100 bp complementarity with the target RNA and ADAR2 recruiting domain from the GluR2 mRNA at either or both the 5? end or the 3? end.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 13, 2022
    Inventors: Prashant Mali, Dhruva Katrekar, Dario Meluzzi, Genghao Chen, Kyle M. Ford