Patents by Inventor Gennady Margolin

Gennady Margolin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CANCER DETECTION AND CLASSIFICATION
    Publication number: 20220290245
    Abstract: The present application provides methods for the detection and classification of cancer. In one aspect, the application provides a method for detecting the presence of cancer in a subject or identifying a biological sample as from a subject with cancer by detecting the methylation status of a panel of eight genomic DNA segments. In another aspect, the application provides a method for classifying a cancer type in a subject or classifying a biological sample as from a subject with a particular cancer type by detecting the methylation status of a panel of 39 genomic DNA segments.
    Type: Application
    Filed: September 11, 2020
    Publication date: September 15, 2022
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Laura L. Elnitski, Gennady Margolin
  • CANCER DETECTION METHODS
    Publication number: 20210180139
    Abstract: The present application provides methods for the detection and diagnosis of cancer. In one aspect, the application provides methods for detecting the presence of cancer in an individual by detecting the methylation state of a region in the promoter of the ZNF154 gene. Methods are provided for detection and diagnosis of cancer from circulating tumor DNA which are minimally invasive and have diagnostic utility across different types and sub-types of cancer. In a further aspect, bioinformatics methods are provided to analyze the methylation state of the ZNF154 promoter and relate the methylation state to the likelihood of cancer in the individual.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 17, 2021
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Servic
    Inventors: Laura L. Elnitski, Gennady Margolin
  • Cancer detection methods
    Patent number: 10961590
    Abstract: The present application provides methods for the detection and diagnosis of cancer. In one aspect, the application provides methods for detecting the presence of cancer in an individual by detecting the methylation state of a region in the promoter of the ZNF154 gene. Methods are provided for detection and diagnosis of cancer from circulating tumor DNA which are minimally invasive and have diagnostic utility across different types and sub-types of cancer. In a further aspect, bioinformatics methods are provided to analyze the methylation state of the ZNF154 promoter and relate the methylation state to the likelihood of cancer in the individual.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: March 30, 2021
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Laura L. Elnitski, Gennady Margolin
  • CANCER DETECTION METHODS
    Publication number: 20180216195
    Abstract: The present application provides methods for the detection and diagnosis of cancer. In one aspect, the application provides methods for detecting the presence of cancer in an individual by detecting the methylation state of a region in the promoter of the ZNF154 gene. Methods are provided for detection and diagnosis of cancer from circulating tumor DNA which are minimally invasive and have diagnostic utility across different types and sub-types of cancer. In a further aspect, bioinformatics methods are provided to analyze the methylation state of the ZNF154 promoter and relate the methylation state to the likelihood of cancer in the individual.
    Type: Application
    Filed: September 15, 2016
    Publication date: August 2, 2018
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human
    Inventors: Laura L. Elnitski, Gennady Margolin