Patents by Inventor Genshi Zhao

Genshi Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD73 inhibitors
    Patent number: 11028074
    Abstract: The present invention provides 5-[5]-[2-cycloalkyl]-6-pyridazin-3-yl]-1H-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 8, 2021
    Assignee: Eli Lilly and Company
    Inventors: Robert Dean Dally, Maria Cristina Garcia Paredes, Lawrence Joseph Heinz, II, Jennifer Marie Howell, Frank George Njoroge, Yan Wang, Genshi Zhao
  • CD73 INHIBITORS
    Publication number: 20210002257
    Abstract: The present invention provides 5-[5]-[2-cycloalkyl]-6-pyridazin-3-yl]-1H-pyrimidine-2,4-dione compounds, or pharmaceutically acceptable salts thereof, that inhibit the activity of CD73 and are useful in treating cancer.
    Type: Application
    Filed: February 22, 2019
    Publication date: January 7, 2021
    Inventors: Robert Dean DALLY, Maria Cristina GARCIA PAREDES, Lawrence Joseph HEINZ II, Jennifer Marie HOWELL, Frank George NJOROGE, Yan WANG, Genshi ZHAO
  • NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS
    Publication number: 20160229835
    Abstract: The present invention provides novel pyridyloxyacetyl tetrahydroisoquinoline compounds that inhibit NAMPT and may be useful in the treatment of cancer.
    Type: Application
    Filed: October 3, 2014
    Publication date: August 11, 2016
    Inventors: Timothy Paul Burkholder, Miriam Filadelfa Del Prado, Maria Carmen Fernandez, Lawrence Joseph Heinz, II, Lourdes Prieto, Genshi Zhao
  • Vinyl indazolyl compounds
    Patent number: 8268869
    Abstract: The present invention provides vinyl indazolyl compounds useful in the treatment of cancer.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: September 18, 2012
    Assignee: Eli Lilly and Company
    Inventors: Daohong Chen, Hong-Yu Li, Genshi Zhao
  • VINYL INDAZOLYL COMPOUNDS
    Publication number: 20100286209
    Abstract: The present invention provides vinyl indazolyl compounds useful in the treatment of cancer.
    Type: Application
    Filed: May 4, 2010
    Publication date: November 11, 2010
    Inventors: Daohong Chen, Hong-Yu Li, Genshi Zhao
  • Use of streptococcus pneumoniae acyl carrier protein synthase crystal structure in diagnostics, antimicrobial drug design, and biosensors
    Publication number: 20030068802
    Abstract: Provided are methods of purifying and crystallizing Streptococcus pneumoniae acyl carrier protein synthase (AcpS) enzyme, crystals of AcpS, the use of such crystals to determine the three-dimensional structure of AcpS enzymes, and the three-dimensional structure of AcpS. The three-dimensional crystal structure of AcpS can be used in medical diagnostics to produce antibodies that permit detection of Streptococcus pneumoniae both in vitro and in vivo. The three-dimensional crystal structure of AcpS can also be used in pharmaceutical discovery and development to identify and design compounds that inhibit the biochemical activity of AcpS enzyme in bacteria. Inhibitory compounds identified in this way can be optimized by structure/activity studies to develop antibacterial pharmaceutical compounds useful for the prevention or treatment of bacterial infections.
    Type: Application
    Filed: June 29, 2001
    Publication date: April 10, 2003
    Inventors: Nicholas Yuri Chirgadze, Stephen Lyle Briggs, Genshi Zhao, Kelly Ann McAllister
  • Streptococcus pneumoniae gene sequence dnaG
    Patent number: 6162617
    Abstract: The invention provides isolated nucleic acid compounds encoding dnaG of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: December 19, 2000
    Assignee: Eli Lilly and Company
    Inventors: Stanley Gene Burgett, Jo Ann Hoskins, Stanley Richard Jaskunas, Jr., Robert Brown Peery, Paul Robert Rosteck, Jr., Genshi Zhao
  • Streptococcus pneumoniaegene sequence era
    Patent number: 6071724
    Abstract: The invention provides isolated nucleic acid compounds encoding Era of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: June 6, 2000
    Assignee: Eli Lilly and Company
    Inventors: Robert Brown Peery, Michele Louise Young Bellido, Genshi Zhao
  • Streptococcus pneumoniae gene sequence Dpj
    Patent number: 6060282
    Abstract: The invention provides isolated nucleic acid compounds encoding dpj of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: May 9, 2000
    Assignee: Eli Lilly and Company
    Inventors: Joseph Chiou-Chung Tang, Patti Jean Treadway, Genshi Zhao
  • Penicillin binding protein from Streptococcus pneumoniae
    Patent number: H2021
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: May 7, 2002
    Assignee: Eli Lilly and Company
    Inventors: JoAnn Hoskins, Stanley Richard Jaskunas, Jr., Genshi Zhao, Pamela Kay Rockey
  • Streptococcus pneumoniae gene sequence for DNA ligase
    Patent number: H2070
    Abstract: The invention provides isolated nucleic acid compounds encoding a DNA ligase of Streptococcus pneumoniae. Also provided are vectors and transformed host cells for expressing the encoded protein, and a method for identifying compounds that bind and/or inhibit said protein.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: July 1, 2003
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, Stanley Richard Jaskunas, Jr., Timothy Ivan Meier, Pamela Kay Rockey, Genshi Zhao
  • Penicillin binding protein from Streptococcus pneumoniae
    Patent number: H2085
    Abstract: The invention provides isolated nucleic acid compounds encoding a novel high molecular weight PBP of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the PBP and a method for identifying compounds that bind and/or inhibit the enzymatic activity of the PBP.
    Type: Grant
    Filed: January 28, 1998
    Date of Patent: October 7, 2003
    Assignee: Eli Lilly and Company
    Inventors: Jo Ann Hoskins, S. Richard Jaskunas, Jr., Genshi Zhao, Pamela K. Rockey, Paul R. Rosteck, Jr., Franklin H. Norris