Patents by Inventor Geo Adam

Geo Adam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glutamate receptor antagonists
    Patent number: 7151098
    Abstract: The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: December 19, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Johannes Woltering
  • Glutamate receptor antagonists
    Publication number: 20060148791
    Abstract: The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification.
    Type: Application
    Filed: February 27, 2006
    Publication date: July 6, 2006
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Woltering
  • Glutamate receptor antagonists
    Patent number: 7018998
    Abstract: The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: March 28, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Johannes Woltering
  • Glutamate receptor antagonists
    Patent number: 6960578
    Abstract: The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: November 1, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Johannes Woltering
  • Glutamate receptor antagonists
    Publication number: 20050234048
    Abstract: The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification.
    Type: Application
    Filed: June 7, 2005
    Publication date: October 20, 2005
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Woltering
  • Dihydro-benzo[b][1,4]diazepin-2-one derivatives
    Patent number: 6949542
    Abstract: This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic heterocycle containing 1 to 3 nitrogen atoms or a pyridine-N-oxide as further defined in the specification. The invention further relates to medicaments containing these compounds, a process for their preparation as well as their use for preparation of medicaments for the treatment or prevention of acute and/or chronic neurological disorders.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: September 27, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Di-or triaza-spiro [4,5] decane derivatives
    Patent number: 6642247
    Abstract: The present invention relates to compounds of the general formula wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or —C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: November 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Andrea Cesura, François Jenck, Sabine Kolczewski, Stephan Röver, Jürgen Wichmann
  • DI-OR TRIAZA-SPIRO [4,5] DECANE DERIVATIVES
    Publication number: 20030176701
    Abstract: The present invention relates to compounds of the general formula 1
    Type: Application
    Filed: June 11, 1999
    Publication date: September 18, 2003
    Inventors: GEO ADAM, ANDREA CESURA, FRANCOIS JENCK, SABINE KOLCZEWSKI, STEPHAN ROVER, JURGEN WICHMANN
  • Dihydro-benzo[b][1,4]diazepin-2-one derivatives
    Publication number: 20030166639
    Abstract: This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula 1
    Type: Application
    Filed: January 24, 2003
    Publication date: September 4, 2003
    Inventors: Geo Adam, Erwin Goetschi, Juergen Wichmann, Thomas Johannes Woltering
  • Glutamate receptor antagonists
    Publication number: 20030092677
    Abstract: The present invention is a compound of formula 1
    Type: Application
    Filed: November 20, 2002
    Publication date: May 15, 2003
    Inventors: Geo Adam, Alaxander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Johannes Woltering
  • Dihydro-benzo [B] [1,4] diazepin-2-one derivatives
    Patent number: 6548495
    Abstract: This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3 and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation and a method of treatment or prevention of acute and/or chronic neurological disorders by administering an effective amount of the compound of formula I or a pharmaceuticall acceptable salt thereof.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 15, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas Johannes Woltering
  • Dihydro-benzo [b][1,4]diazepin-2-one derivatives
    Patent number: 6544985
    Abstract: This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula wherein R1, R2, R3, X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing these compounds, a process for their preparation, their use in preparation of pharmaceutical compositions and administration of an effective amount of the compounds for the treatment or prevention of acute and/or chronic neurological disorders to a patient in need of such treatment.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 8, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas Johannes Woltering
  • Glutamate receptor antagonists
    Patent number: 6509328
    Abstract: The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: January 21, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Johannes Woltering
  • Dihydro-benzo [b] [1,4] diazepin-2-one derivatives
    Publication number: 20020198197
    Abstract: This invention is a dihydro-benzo [b] [1,4] diazepin-2-one derivative of the formula 1
    Type: Application
    Filed: April 3, 2002
    Publication date: December 26, 2002
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas J. Woltering
  • Dihydro-benzo [b] [1,4] diazepin-2-one derivatives
    Publication number: 20020193367
    Abstract: This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula 1
    Type: Application
    Filed: April 3, 2002
    Publication date: December 19, 2002
    Inventors: Geo Adam, Erwin Goetschi, Vincent Mutel, Juergen Wichmann, Thomas Johannes Woltering
  • Glutamate receptor antagonists
    Patent number: 6407094
    Abstract: The present invention relates to compounds of with a base structure of formula 1 The compounds of formula I are shown to have activity as metabotropic glutamate receptor antagonists.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: June 18, 2002
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Geo Adam, Alexander Alanine, Erwin Goetschi, Vincent Mutel, Thomas Johannes Woltering
  • Heterocyclic vinyl ethers
    Patent number: 6248901
    Abstract: The compounds of the formula wherein R signifies halogen or lower alkyl; n signifies 0-3; R1 signifies lower alkyl; cycloalkyl; benzyl optionally substituted by hydroxy, halogen, lower alkoxy or lower alkyl; benzoyl optionally substituted by amino, lower alkylamino or di-lower alkylamino; acetyl or cycloalkyl-carbonyl; and signifies an aromatic 5-membered residue which is bonded via a N-atom and which contains further 1-3 N atoms in addition to the linking N atom, as well as their pharmaceutically acceptable salts as therapeutically active substances, especially for the control or prevention of acute and/or chronic neurological disorders.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: June 19, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Sabine Kolczewski, Vincent Mutel, Heinz Stadler, Jürgen Wichmann, Thomas Johannes Woltering
  • 1,2,4,5-Tetrahydro-benzo[D]azepin derivatives
    Patent number: 6218385
    Abstract: The present invention is concerned with 1,2,4,5-tetrahydro-benzo[d]azepin derivatives as well as with their pharmaceutically acceptable salts in their racemic and optically active form, which compounds are antagonists at metabotropic glutamate receptors and therefore useful for the treatment of diseases related to these receptors.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: April 17, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Alfred Binggeli, Hans-Peter Märki, Vincent Mutel, Maurice Wilhelm, Wolfgang Wostl
  • Di-or triaza-spiro [4,5] decane derivatives
    Patent number: 6172075
    Abstract: The present invention relates to compounds of the general formula wherein R1 is C6-10-cycloalkyl, optionally substituted by lower alkyl or —C(O)O-lower alkyl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; indan-1-yl or indan-2-yl, optionally substituted by lower alkyl; decahydro-azulen-2-yl; bicyclo[6.2.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: January 9, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Geo Adam, Andrea Cesura, François Jenck, Sabine Kolczewski, Stephan Röver, J{umlaut over (u)}rgen Wichmann
  • Piperidine derivatives
    Patent number: 6166209
    Abstract: The present invention relates to compounds of the formula ##STR1## wherein X is --O-- or --CH.sub.2 --;Y is --C(O)--, --(CH.sub.2).sub.n -- or --N(CH.sub.3)--;n is 1 or 2 orX and Y taken together are --CH.dbd.CH--Z is --NH--, --CH.sub.2 --, --O-- or .dbd.CH--;A.sup.1 is a group ##STR2## B is --(CH.sub.2).sub.m --; m is 0, 1 or 2;R.sup.1 and R.sup.2 are each independently hydrogen or lower alkyl;R.sup.3 is hydrogen or halogen;R.sup.4 is hydrogen or hydroxy andthe dotted line is (--CH.sub.2 --CH.sub.2 --).sub.n, and n' is 0 or 1 and to pharmaceutically acceptable acid addition salts thereof.The compounds of the present invention are antagonists of the OFQ receptor.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: December 26, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Geo Adam, Andrea Cesura, Guido Galley, Fran.cedilla.ois Jenck, Stephan Rover, Jurgen Wichmann