Patents by Inventor Geoff Facer
Geoff Facer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230112068Abstract: Magnetic levitation particle separation systems and methods for use with multi-channel flow cells. The system may include a core for receiving and holding the flow cell, with upper and lower clamps for securing the flow cell and positioning it relative to an array of magnets. The system is configured to image particle separation in processing channels of the flow cell, and to regulate the flow cell's temperature. The core may be removable as a single unit, facilitating reconfiguration of the system.Type: ApplicationFiled: October 7, 2022Publication date: April 13, 2023Applicant: LevitasBio, Inc.Inventors: Theodorus Evan de Groot, Geoff Facer, Amirreza Malekanfard, Gang Sun, Lesley Suzanne Weaver
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Publication number: 20220323957Abstract: The present invention relates methods for separation and/or concentration of cell nuclei and/or live cells from cellular and nuclear debris, and dead cells using magnetic levitation.Type: ApplicationFiled: January 19, 2022Publication date: October 13, 2022Inventors: Seth BRODIE, Geoff FACER, Susana JETT, Kevin TRAVERS
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Patent number: 11465147Abstract: A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.Type: GrantFiled: June 29, 2019Date of Patent: October 11, 2022Assignee: INDEE. PTY. LTD.Inventors: Ryan Pawell, Amy Twite, Geoff Facer, Katherine Lau, Adrian Lievano, Julyana Acevedo
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Publication number: 20220161260Abstract: A fluidic concentrator device that includes an inlet channel, a processing channel, and at least two output channels, and a pump for movement of a particle containing sample through the concentrator device. The concentrator device may have separate diversion channels that may be controlled by a valve or a functionally similar diversion technique to collect all of, or fractions of, a particle concentrated stream or a particle depleted stream. The concentrator device may be operable under automated control and further comprise one or more sensors inside, or adjacent to, portions of the processing channel or inlet channel to detect presence or absence or quantity of particles or other physical or chemical properties of the particles or sample flow stream.Type: ApplicationFiled: November 29, 2021Publication date: May 26, 2022Inventors: Geoff FACER, Kevin TRAVERS, Theodorus DE GROOT
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Publication number: 20210339252Abstract: A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.Type: ApplicationFiled: July 5, 2021Publication date: November 4, 2021Inventors: Ryan Pawell, Amy Twite, Geoff Facer, Katherine Lau, Adrian Lievano, Julyana Acevedo
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Patent number: 11052394Abstract: A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.Type: GrantFiled: November 2, 2018Date of Patent: July 6, 2021Assignee: INDEE. PTY. LTD.Inventors: Ryan Pawell, Amy Twite, Geoff Facer, Katherine Lau, Adrian Lievano, Julyana Acevedo
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Publication number: 20200385759Abstract: A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.Type: ApplicationFiled: November 2, 2018Publication date: December 10, 2020Inventors: Ryan Pawell, Amy Twite, Geoff Facer, Katherine Lau, Adrian Lievano, Julyana Acevedo
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Publication number: 20190321825Abstract: A method and device for transfecting a cell to introduce an exogenous material into the cell. The method includes exposing the cell to a region of unsteady flow in the presence of an electric field to encourage introduction of the exogenous material into a cell without lysing the cell.Type: ApplicationFiled: June 29, 2019Publication date: October 24, 2019Inventors: Ryan Pawell, Amy Twite, Geoff Facer, Katherine Lau, Adrian Lievano, Julyana Acevedo
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Publication number: 20160289669Abstract: Disclosed herein are devices and systems comprising a) a substrate comprising at least 100 microwells and a plurality of beads, wherein a plurality of the at least 100 microwells each contain a single bead, and wherein the ratio of the average diameter of the microwells to the diameter of the beads ranges from about 1.2 to about 1.8; b) a flow cell in fluid communication with the substrate; and c) at least one inlet port and at least one outlet port, wherein the at least one inlet port and at least one outlet port are capable of directing a flow of a fluid through the flow cell, thereby contacting the microwells with the fluid.Type: ApplicationFiled: January 22, 2016Publication date: October 6, 2016Inventors: Christina Fan, Stephen P.A. Fodor, Glenn Fu, Geoff Facer, David Stern, Janice Lai, Ari Chaney, Phillip Spuhler, Sixing Li, Xiaohua Chen Huang, Kimberly R. Metzler, Elisabeth Marie Walczak
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Patent number: 9383295Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: GrantFiled: September 4, 2014Date of Patent: July 5, 2016Assignee: Fluidigm CorporationInventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Publication number: 20160055632Abstract: Methods, systems and platforms for digital imaging of multiple regions of an array, and detection and counting of the labeled features thereon, are described.Type: ApplicationFiled: October 7, 2014Publication date: February 25, 2016Inventors: Glenn Fu, Roger Rudoff, David Stern, George T. Wu, Stephen P.A. Fodor, Geoff Facer
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Publication number: 20150185118Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: ApplicationFiled: September 4, 2014Publication date: July 2, 2015Inventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Publication number: 20140045184Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: ApplicationFiled: March 4, 2013Publication date: February 13, 2014Applicant: Fluidigm CorporationInventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Patent number: 8440093Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.Type: GrantFiled: October 11, 2006Date of Patent: May 14, 2013Assignee: Fuidigm CorporationInventors: Hany Nassef, Geoff Facer, Marc Unger
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Patent number: 8389960Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: GrantFiled: November 11, 2011Date of Patent: March 5, 2013Assignee: Fluidigm CorporationInventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Publication number: 20120261007Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: ApplicationFiled: November 11, 2011Publication date: October 18, 2012Applicant: Fluidigm CorporationInventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Patent number: 8058630Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: GrantFiled: January 15, 2010Date of Patent: November 15, 2011Assignee: Fluidigm CorporationInventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Publication number: 20100230613Abstract: Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device.Type: ApplicationFiled: January 15, 2010Publication date: September 16, 2010Applicant: Fluidigm CorporationInventors: Martin Pieprzyk, Geoff Facer, Timothy Woudenberg, Brian Fowler
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Patent number: 7666361Abstract: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses.Type: GrantFiled: April 5, 2004Date of Patent: February 23, 2010Assignee: Fluidigm CorporationInventors: Lincoln McBride, Marc Unger, Michael Lucero, Hany Ramez Nassef, Geoff Facer, Yong Yi
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Patent number: D1015568Type: GrantFiled: October 7, 2021Date of Patent: February 20, 2024Assignee: LEVITASBIO, INC.Inventors: Theodore Evan de Groot, Geoff Facer