Patents by Inventor Geoff Otto

Geoff Otto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified surfaces for immobilization of active molecules
    Publication number: 20080241892
    Abstract: Modified surfaces, substrates, and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide either non-reactive surfaces or low density reactive groups, preferably on an otherwise non-reactive surface, for use in different applications including single molecule analyses.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 2, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: Daniel Bernardo Roitman, Geoff Otto, Ronald L. Cicero, Nelson R. Holcomb
  • Articles having localized molecules disposed thereon and methods of producing same
    Publication number: 20080176769
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: October 26, 2007
    Publication date: July 24, 2008
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto
  • Articles having localized molecules disposed thereon and methods of producing same
    Publication number: 20080032301
    Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
    Type: Application
    Filed: March 29, 2007
    Publication date: February 7, 2008
    Applicant: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
    Inventors: David Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto
  • Polymerases for nucleotide analogue incorporation
    Publication number: 20070196846
    Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
    Type: Application
    Filed: December 21, 2006
    Publication date: August 23, 2007
    Applicant: Pacific Biosciences of California, Inc.
    Inventors: David Hanzel, Geoff Otto, Devon Murphy, Paul Peluso, Thang Pham, David Rank, Paul Mitsis