Patents by Inventor Geoffrey A. Barrall

Geoffrey A. Barrall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High contrast signal to noise ratio device components
    Patent number: 11460435
    Abstract: Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: October 4, 2022
    Assignee: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • Modified alpha hemolysin polypeptides and methods of use
    Patent number: 10906945
    Abstract: Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided herein are apparatuses and devices comprising modified hemolysin polypeptides. Also provided herein are methods of using modified alpha hemolysin proteins for use in characterizing and/or sequencing a polymer or for use as molecular sensors.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: February 2, 2021
    Assignee: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • Site specific chemically modified nanopore devices
    Patent number: 10234415
    Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 19, 2019
    Assignee: Electronic BioSciences, Inc.
    Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
  • High contrast signal to noise ratio device components
    Patent number: 10228347
    Abstract: Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: March 12, 2019
    Assignee: Electronic BioSciences, Inc.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • SITE SPECIFIC CHEMICALLY MODIFIED NANOPORE DEVICES
    Publication number: 20180321180
    Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 8, 2018
    Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
  • Modified alpha hemolysin polypeptides and methods of use
    Patent number: 10047129
    Abstract: Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided herein are apparatuses and devices comprising modified hemolysin polypeptides. Also provided herein are methods of using modified alpha hemolysin proteins for use in characterizing and/or sequencing a polymer or for use as molecular sensors.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: August 14, 2018
    Assignee: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • Site specific chemically modified nanopore devices
    Patent number: 10006879
    Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: June 26, 2018
    Assignee: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
  • MODIFIED ALPHA HEMOLYSIN POLYPEPTIDES AND METHODS OF USE
    Publication number: 20150329600
    Abstract: Provided herein are alpha hemolysin polypeptides comprising modified amino acid sequences that can reduce the rate of translocation of a polymer. Also provided herein are apparatuses and devices comprising modified hemolysin polypeptides. Also provided herein are methods of using modified alpha hemolysin proteins for use in characterizing and/or sequencing a polymer or for use as molecular sensors.
    Type: Application
    Filed: December 19, 2013
    Publication date: November 19, 2015
    Inventors: Geoffrey A. BARRAL, Eric N. ERVIN, Prithwish PAL
  • METHODS FOR CHARACTERIZING A DEVICE COMPONENT BASED ON A CONTRAST SIGNAL TO NOISE RATIO
    Publication number: 20140248608
    Abstract: The general concept of using a nanopore for DNA sequencing is to electrophoretically drive a polymer (e.g. single stranded DNA) through a nanopore under aqueous conditions, and identify each individual monomer (e.g. nucleotide) of the strand as it passes through the sensitive region of the nanopore based on its characteristic current modulation.
    Type: Application
    Filed: June 22, 2012
    Publication date: September 4, 2014
    Applicant: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • HIGH CONTRAST SIGNAL TO NOISE RATIO DEVICE COMPONENTS
    Publication number: 20140216933
    Abstract: Provided are device components, devices and methods characterized by a high contrast signal to noise ratio (CNR).
    Type: Application
    Filed: June 22, 2012
    Publication date: August 7, 2014
    Applicant: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Geoffrey A. Barrall, Eric N. Ervin, Prithwish Pal
  • SITE SPECIFIC CHEMICALLY MODIFIED NANOPORE DEVICES
    Publication number: 20140106472
    Abstract: Provided are site specific chemically modified nanopore devices and methods for manufacturing and using them. Site specific chemically modified nanopore devices can be used for analyte sensing and analysis, for example.
    Type: Application
    Filed: April 11, 2012
    Publication date: April 17, 2014
    Applicant: ELECTRONIC BIOSCIENCES, INC.
    Inventors: Eric N. Ervin, John J. Watkins, Geoffrey A. Barrall
  • Method and system for cancellation of extraneous signals in nuclear quadrupole resonance spectroscopy
    Patent number: 6392408
    Abstract: A method and system for canceling extraneous signals in a nuclear quadrupole resonance (NQR) system used for the detection of explosives and drugs. A specimen is irradiated with a specific sequence of electromagnetic pulses, referred to as a spin-locked inversion mid-echo (SLIME) pulse sequence with each pulse having a specified phase and duration. The pulses are separated by specified time intervals. The SLIME pulse sequence has a single excitation pulse. As a result of the characteristics of the SLIME pulse sequence, if the target substance to be detected is present in the specimen, sets of oppositely-phased NQR echo signals are generated from the target substance. NQR echo signals of one phase are subtracted from NQR echo signals having the opposite phase, rendering a cumulative echo signal, and simultaneously subtracting out the same-phase extraneous signal.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: May 21, 2002
    Assignee: Quamtum Magnetics, Inc.
    Inventors: Geoffrey A. Barrall, Lowell J. Burnett, Alan G. Sheldon
  • Measurement of the resin content of a composite material by nuclear magnetic resonance
    Patent number: 5818228
    Abstract: The resin content of an organic resin-matrix composite material is measured nondestructively by nuclear magnetic resonance. A specimen of the composite material is placed into a constant magnetic field and subjected to a radio-frequency magnetic field pulse. The response of the material is indicative of the amount of organic resin that is present. The response may be used as a feedback signal to control the operation of a manufacturing machine.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: October 6, 1998
    Assignee: XXSYS Technologies, Inc.
    Inventors: Suresh M. Menon, Geoffrey A. Barrall, Erik E. Magnuson