Patents by Inventor Geoffrey Bilcer

Geoffrey Bilcer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20100267609
    Abstract: Compounds inhibit memapsin 2 ?-secretase activity and selectively inhibit memapsin 2 ?-secretase activity relative to memapsin 1 ?-secretase activity. The compounds are employed in methods to inhibit memapsin 2 ?-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a ?-secretase site of a ?-amyloid precursor protein and to decrease ?-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
    Type: Application
    Filed: June 9, 2009
    Publication date: October 21, 2010
    Inventors: Arun K. GHOSH, Jordan J. N. Tang, Geoffrey Bilcer, Wanpin Chang, Lin Hong, Gerald E. Koelsch, Jeffrey A. Loy, Robert T. Turner, III, Thippeswamy Devasumadram
  • Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof
    Publication number: 20080207527
    Abstract: The present invention provides bicyclic beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Application
    Filed: September 19, 2005
    Publication date: August 28, 2008
    Applicants: CoMentis, Inc., The Board of Trutees of the University of Illinois, Oklahoma Medical Research Foundation
    Inventors: Arun K. Ghosh, Hui Lei, Thippeswamy Devasamudram, Chunfeng Liu, Jordan J.N. Tang, Geoffrey Bilcer
  • COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF
    Publication number: 20080176939
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: August 1, 2007
    Publication date: July 24, 2008
    Applicants: CoMentis, Inc., The Board of Trustees of the University of Illinois, Oklahoma Medical Research Foundation, Purdue Research Foundation
    Inventors: Arun K. Ghosh, Nagaswamy Kumaragurubaran, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa Swanson, Sudha Ankala, Jordan Tang, Geoffrey Bilcer
  • Amino-Containing Compounds Which Inhibit Memapsin 2 Beta-Secretase Activity and Methods of Use Thereof
    Publication number: 20080125467
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Application
    Filed: September 19, 2005
    Publication date: May 29, 2008
    Inventors: Arun K. Ghosh, Hui Lei, Thippeswamy Devasamudram, Jordan J. N. Tang, Geoffrey Bilcer, Chungfeng Liu
  • Beta-secretase inhibitors and methods of use thereof
    Patent number: 7335632
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: February 26, 2008
    Assignee: CoMentis, Inc.
    Inventors: Arun K. Ghosh, Hui Lei, Thippeswamy Devasamudram, Chunfeng Liu, Jordan J. N. Tang, Geoffrey Bilcer
  • Compounds Which Inhibit Beta-Secretase Activity and Methods of Use
    Publication number: 20070117793
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
    Type: Application
    Filed: August 9, 2006
    Publication date: May 24, 2007
    Applicants: Zapaq, Inc., The Board of Trustees of the University of Illinois, Oklahoma Medical Research Foundation, Purdue Research Foundation
    Inventors: Arun Ghosh, Nagaswamy Kumaragurubaran, Chunfeng Liu, Thippeswamy Devasamudram, Hui Lei, Lisa Swanson, Sudha Ankala, Jordan Tang, Geoffrey Bilcer
  • HIV protease inhibitors
    Publication number: 20070082883
    Abstract: Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.
    Type: Application
    Filed: November 7, 2006
    Publication date: April 12, 2007
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Arun Ghosh, Geoffrey Bilcer, Thippeswamy Devasamudram
  • Beta-secretase inhibitors and methods of use
    Publication number: 20060234944
    Abstract: Compounds inhibit memapsin 2 ?-secretase activity and selectively inhibit memapsin 2 ?-secretase activity relative to memapsin 1 ?-secretase activity. The compounds are employed in methods to inhibit memapsin 2 ?-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a ?-secretase site of a ?-amyloid precursor protein and to decrease ?-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
    Type: Application
    Filed: October 23, 2002
    Publication date: October 19, 2006
    Applicants: Oklahoma Medical Reseach Foundation, The Board of Trustees of the University of Illinois
    Inventors: Arun Ghosh, Jordan Tang, Geoffrey Bilcer, Wanpin Chang, Lin Hong, Gerald Koelsch, Jeff Loy, Robert Turner III
  • Compounds which inhibit beta-secretase activity and methods of use thereof
    Publication number: 20050239684
    Abstract: The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease.
    Type: Application
    Filed: September 17, 2004
    Publication date: October 27, 2005
    Applicants: Zapaq, Inc., The Board of Trustees of the University of Illinois, Oklahoma Medical Research Foundation
    Inventors: Arun Ghosh, Jordan Tang, Hui Lei, Thippeswamy Devasamudram, Chunfeng Liu, Geoffrey Bilcer
  • Compounds which inhibit beta-secretase activity and methods of use thereof
    Publication number: 20040121947
    Abstract: Compounds inhibit memapsin 2 &bgr;-secretase activity and selectively inhibit memapsin 2 &bgr;-secretase activity relative to memapsin 1 &bgr;-secretase activity. The compounds are employed in methods to inhibit memapsin 2 &bgr;-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a &bgr;-secretase site of a &bgr;amyloid precursor protein and to decrease &bgr;-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.
    Type: Application
    Filed: October 23, 2002
    Publication date: June 24, 2004
    Applicants: Oklahoma Medical Research Foundation, The Board of Trustees of the University of Illinois
    Inventors: Arun K. Ghosh, Jordan J. N. Tang, Geoffrey Bilcer, Wanpin Chang, Lin Hong, Gerald E. Koelsch, Jeffrey A. Loy, Robert T. Turner, Thippeswamy Devasumadram