Patents by Inventor Geoffrey C. Gurtner

Geoffrey C. Gurtner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10751304
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1? in the wound.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: August 25, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
  • Publication number: 20200253899
    Abstract: Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally by applying a transdermal delivery device to a tissue surface at the treatment site in multiple discrete doses. The transdermal delivery system comprises DFO encapsulated in reverse micelles.
    Type: Application
    Filed: September 12, 2018
    Publication date: August 13, 2020
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Derrick C. WAN, Geoffrey C. GURTNER, Michael T. LONGAKER
  • Patent number: 10603161
    Abstract: Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is cured in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 31, 2020
    Assignee: TauTona Group Research and Development Company, L.L.C.
    Inventors: Kenneth N. Horne, Michael H. Rosenthal, Geoffrey C. Gurtner
  • Publication number: 20200046653
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds such as pressure ulcers by transdermal delivery of an agent that increases activity of HIF-1alpha in the wound. Wound healing ability reduced in aged subjects can be restored by use of the iron chelator formulations and methods to be similar to that of young subjects.
    Type: Application
    Filed: August 6, 2019
    Publication date: February 13, 2020
    Inventor: Geoffrey C. Gurtner
  • Patent number: 10548860
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: February 4, 2020
    Assignees: The Board Of Trustees of The Leland Stanford Junior University, The United States Government as Represented By The Department Of Veterans Affairs, The Johns Hopkins University
    Inventors: Mark R. Nicolls, Jayakumar Rajadas, Geoffrey C. Gurtner, Xinguo Jiang, Gundeep Dhillon, Gregg L. Semenza
  • Publication number: 20200009038
    Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
    Type: Application
    Filed: August 30, 2019
    Publication date: January 9, 2020
    Inventors: Geoffrey C. GURTNER, Kenneth N. HORNE, Jayakumar RAJADAS
  • Publication number: 20190358412
    Abstract: Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.
    Type: Application
    Filed: July 25, 2019
    Publication date: November 28, 2019
    Inventors: Geoffrey C. Gurtner, Michael H. Rosenthal, Brian J. Domecus, Darin Gittings, Kinman Hong
  • Patent number: 10463595
    Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: November 5, 2019
    Assignee: ALLERGAN HOLDINGS FRANCE S.A.S.
    Inventors: Geoffrey C. Gurtner, Kenneth N. Horne, Jayakumar Rajadas
  • Patent number: 10406297
    Abstract: Devices and methods for tissue transfer are described where a cannula may be inserted into the breast of a subject at one of several points of entry. Insertion of the cannula into the breast may be accomplished by using a guidance system to distinguish between tissue types. Once desirably positioned, the cannula may be withdrawn from the breast while automatically (or manually) injecting the fat in multiple deposits of adipose tissue or fat such that the deposited fat remains within the tract formed by the withdrawn cannula. Multiple tracts of the deposited fat may be injected within the breast until the breast has been desirably remodeled and/or augmented.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: September 10, 2019
    Assignee: LifeCell Corporation
    Inventors: Geoffrey C. Gurtner, Michael H. Rosenthal, Brian J. Domecus, Darin Gittings, Kinman Hong
  • Publication number: 20190192452
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
    Type: Application
    Filed: January 29, 2019
    Publication date: June 27, 2019
    Inventors: Mark R. Nicolls, Jayakumar Rajadas, Geoffrey C. Gurtner, Xinguo Jiang, Gundeep Dhillon, Gregg L. Semenza
  • Patent number: 10220009
    Abstract: Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: March 5, 2019
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Johns Hopkins University, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Mark R. Nicolls, Jayakumar Rajadas, Geoffrey C. Gurtner, Xinguo Jiang, Gundeep Dhillon, Gregg L. Semenza
  • Publication number: 20190015255
    Abstract: The methods, procedures, kits, and devices described herein assist with the healing process of tissue that was previously or simultaneously treated for a therapeutic or cosmetic effect. The methods, procedures, kits, and devices described herein can also provide temporary simulated results of a cosmetic procedure to allow for visual assessment to select the type of procedure or for treatment planning in advance of the surgical procedure.
    Type: Application
    Filed: July 3, 2018
    Publication date: January 17, 2019
    Inventors: Geoffrey C. GURTNER, Michael T. LONGAKER, Reinhold H. DAUSKARDT, Paul YOCK, John A. ZEPEDA, Kenneth N. HORNE, Bankim H. MEHTA, Michael H. ROSENTHAL, Joseph RIMSA, Sergio SALINAS, Melanie HARRIS, Greg SPOONER, Kin CHAN
  • Publication number: 20190008807
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1? in the wound.
    Type: Application
    Filed: September 11, 2018
    Publication date: January 10, 2019
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
  • Publication number: 20180360669
    Abstract: Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.
    Type: Application
    Filed: February 6, 2018
    Publication date: December 20, 2018
    Inventors: Geoffrey C. GURTNER, Reinhold H. DAUSKARDT, Michael T. LONGAKER, Paul YOCK
  • Publication number: 20180344610
    Abstract: The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.
    Type: Application
    Filed: January 8, 2018
    Publication date: December 6, 2018
    Inventors: Geoffrey C. Gurtner, Kenneth N. Horne, Jayakumar Rajadas
  • Patent number: 10098857
    Abstract: Compositions and methods are provided for the prevention and treatment of chronic wounds, including, without limitation, pressure ulcers and diabetic ulcers, by transdermal delivery of an agent that increases activity of HIF-1? in the wound.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: October 16, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Geoffrey C. Gurtner, Jayakumar Rajadas, Michael Gabriel Galvez, Evgenios Neofytou
  • Publication number: 20180214571
    Abstract: Compositions and methods are provided for delivery of stem cells to a targeted tissue. A population of stem cells, including for example a regenerative stem cell population, is bound to magnetic vesicular particles. The magnetic vesicular particles comprise one or more magnetic nanoparticles within a lipid membrane, e.g. a liposomal structure. The cells are delivered to a targeted tissue by application of a magnetic field.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 2, 2018
    Inventors: Jayakumar Rajadas, Mohammadreza Mohammadi, Mohammed Inayathullah, Geoffrey C. Gurtner, Tejal Ashwin Desai
  • Publication number: 20180193353
    Abstract: One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 12, 2018
    Inventors: Geoffrey C. Gurtner, Michael A. Brownlee
  • Publication number: 20180104107
    Abstract: Devices, kits and methods described herein may be for treatment to skin, including but not limited to wound healing, the treatment, amelioration, and/or prevention of scars or keloids. A book-like packaging, applicator and/or tensioning device may be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device may apply and/or maintain a strain in an elastic dressing.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 19, 2018
    Inventors: Jasper JACKSON, John A. ZEPEDA, Adam C. FRENCH, Darren G. DOUD, Geoffrey C. GURTNER, Brett A. FOLLMER, William R. BEASLEY, Paul YOCK, Keiichiro ICHIRYU, Manuel A. CARDONA PAMPLONA, Tor C. KROG, Kemal LEVI
  • Publication number: 20180071265
    Abstract: One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or preventive therapy. This method involves administering a composition containing a therapeutically effective amount of a ROS inhibitor to a subject in need thereof.
    Type: Application
    Filed: July 28, 2017
    Publication date: March 15, 2018
    Inventors: Geoffrey C. Gurtner, Michael A. Brownlee