Abstract: In one aspect, the invention relates to peptides comprising the Bcr-Abl coiled-coil oligomerization domain and an alpha helix stabilizing moiety, mutant forms thereof, truncated forms thereof, derivatives thereof, and related peptides, which are useful as inhibitors of the Bcr-Abl chimeric protein; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with Bcr-Abl using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: In one aspect, the invention relates to peptides comprising the Bcr-Abl coiled-coil oligomerization domain and an alpha helix stabilizing moiety, mutant forms thereof, truncated forms thereof, derivatives thereof, and related peptides, which are useful as inhibitors of the Bcr-Abl chimeric protein; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with Bcr-Abl using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A system for the transmission of data from a number of out-station transmitters to a central receiver over a communication line or channel in which each out-station transmitter has an associated timer and a detector which "listens" to the line or channel and enables the transmitter only in the absence of detected signals from the other transmitters on the line or channel. When enabled each transmitter transmits data over the line or channel under control of its associated timer for a time interval during which the other transmitters are inhibited. The time intervals commence from the start times which differ from each other by different random delays which are short compared with the timed intervals, so that upon initial switching on of the system one of the transmitters will always commence transmission, followed by all the other transmitters in sequence.

Abstract: In order to detect derailment of a railway vehicle each vehicle in a train is provided with an acceleration responsive device which, in response to the vehicle acceleration resulting from derailment of the vehicle transmits a short range radio signal to a receiver installed in the engine to provide a visual or audio alarm. In one practical arrangement requiring no routine maintenance each transmitter unit has a resonant circuit which is energized as a result of the stressing of a piezo-electric crystal upon vehicle derailment, avoiding the need for any separate electrical power source on the vehicle.