Patents by Inventor Geoffrey Davis

Geoffrey Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EPITOPE-DRIVEN HUMAN ANTIBODY PRODUCTION AND GENE EXPRESSION PROFILING
    Publication number: 20020029391
    Abstract: The present invention provides a method of biasing the immune response of a mammal toward a desired epitope of a chosen antigen, particularly a functionally-relevant epitope. In preferred embodiments, the epitope-biasing method leads to fully-human antibodies of defined specificity with affinities of 10 nM to 50 pM. The invention further provides antibody libraries biased to tissues and to cell types, for use in generating epitope expression profiles useful for characterizing unknown genes. When all aspects of the present invention are combined, they result in an integrated system for defining critical epitopes on newly discovered gene products and rapidly devloping therapeutic grade antibodies to those critical epitopes.
    Type: Application
    Filed: April 15, 1998
    Publication date: March 7, 2002
    Inventors: CLAUDE GEOFFREY DAVIS, AYA JAKOBOVITS
  • Production of a multimeric protein by cell fusion method
    Patent number: 6207418
    Abstract: The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
    Type: Grant
    Filed: June 29, 1999
    Date of Patent: March 27, 2001
    Assignees: Abgenix, Inc., Japan Tobacco Inc.
    Inventors: Nobuaki Hori, Claude Geoffrey Davis, Krisztina M. Zsebo, Aya Jakobovits
  • Production of a multimeric protein by cell fusion method
    Patent number: 5916771
    Abstract: The present invention features a method of producing a multimeric protein from a hybrid cell formed from the fusion of two or more cells, each of which cell is engineered to express one component of the multimeric protein, as well as a method for screening for successful fusion of the cells to produce a desired hybrid cell. The methods of the invention are widely applicable to the production of proteins having two or more components.
    Type: Grant
    Filed: October 11, 1996
    Date of Patent: June 29, 1999
    Assignees: Abgenix, Inc., Japan Tobacco Inc.
    Inventors: Nobuaki Hori, Claude Geoffrey Davis, Krisztina M. Zsebo, Aya Jakobovits
  • Clamping devices for spring assemblies
    Patent number: 4623133
    Abstract: A device for clamping together at least two leaves of a leaf spring assembly and a resilient plate member in superimposed interfacial contact comprises at least one clasp adapted to embrace the leaves and the resilient member. A closure plate or bar is secured to the free ends of the clasp to impose a clamping force on the members embraced by the clasp. The closure plate or bar is formed with a raised surface which co-operates with an adjacent surface of a member embraced by the clasp to permit angular movement of the clasp relative to the embraced members.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: November 18, 1986
    Assignee: British Steel Corporation
    Inventors: Geoffrey Davis, Graham K. Beal