Patents by Inventor Geoffrey E. Gymer

Geoffrey E. Gymer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7129234
    Abstract: The invention relates to compounds of formula I
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: October 31, 2006
    Assignee: Pfizer Inc.
    Inventors: Mavis D. Adam, Mark D. Andrews, Geoffrey E. Gymer, David Hepworth, Harry R. Howard, Jr., Donald S. Middleton, Alan Stobie
  • Publication number: 20040106594
    Abstract: The invention relates to compounds of formula I 1
    Type: Application
    Filed: November 25, 2003
    Publication date: June 3, 2004
    Applicant: Pfizer Inc
    Inventors: Mavis D. Adam, Mark D. Andrews, Geoffrey E. Gymer, David Hepworth, Harry R. Howard, Donald S. Middleton, Alan Stobie
  • Publication number: 20030207857
    Abstract: The invention relates to compounds of formula I 1
    Type: Application
    Filed: April 11, 2002
    Publication date: November 6, 2003
    Inventors: Mavis D. Adam, Mark D. Andrews, Geoffrey E. Gymer, David Hepworth, Harry R. Howard, Donald S. Middleton, Alan Stobie
  • Patent number: 5047548
    Abstract: Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof, wherein R is 5-chloro-2-pyridyl, or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; R.sup.1 is CN, CSNH.sub.2 or CONR.sup.2 R.sup.3 where either(a) R.sup.2 is H or certain alkyl groups and R.sup.3 is H or certain alkyl, substituted alkyl, aralkyl, phenyl or cycloalkyl groups, or(b) R.sup.2 and R.sup.3 taken together with the nitrogen atom to which they are attached form a nitrogen heterocyclic group, optionally containing an oxygen atom or NR.sup.4 group, as a ring member and R.sup.4 is H, C.sub.1 -C.sub.4 alkyl; C.sub.2 -C.sub.4 alkanoyl or (C.sub.1 -C.sub.4 alkoxy)carbonyl;R.sup.5 and R.sup.6 are each H or CH.sub.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: September 10, 1991
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Geoffrey E. Gymer
  • Patent number: 5023258
    Abstract: The invention provides triazole antifungal compounds of the formula: ##STR1## wherein R is either (a) a phenyl group optionally substituted with 1 to 3 substituents, each selected independently from halo and CF.sub.3 ; or(b) a 5-chloropyridin-2-yl group; and R.sup.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: June 11, 1991
    Assignee: Pfizer Inc.
    Inventors: Geoffrey E. Gymer, Subramaniyan Narayanaswami, Kenneth Richardson
  • Patent number: 4960782
    Abstract: Triazoles of the formula ##STR1## where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, or R is 5-chloro-pyrid-2-yl; and R.sup.1 is H, CH.sub.3 or F; and their pharmaceutically and agriculturally acceptable salts. The compounds are useful as human and agricultural fungicides.
    Type: Grant
    Filed: October 23, 1989
    Date of Patent: October 2, 1990
    Assignee: Pfizer Inc.
    Inventors: Geoffrey E. Gymer, Kenneth Richardson
  • Patent number: 4661507
    Abstract: Compounds of the general formula: ##STR1## wherein R is naphthyl, biphenylyl, phenyl or substituted phenyl; n is 0, 1 or 2; and R.sup.1 is H, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-4 alkanoyl, or C.sub.1-2 alkyl substituted by C.sub.2-4 alkenyl with the provisos that when R.sup.1 is H or C.sub.2-4 alkanoyl, n is 0; and when n is 2, R.sup.1 is C.sub.1-3 alkyl; and their pharmaceutically acceptable salts are antifungal agents useful in combatting fungal infections in animals, including humans.
    Type: Grant
    Filed: August 28, 1984
    Date of Patent: April 28, 1987
    Assignee: Pfizer Inc.
    Inventors: Geoffrey E. Gymer, Kenneth Richardson
  • Patent number: 4585778
    Abstract: Triazole antifungal agents of the formula: ##STR1## and their O-esters and O-ethers, where R is a phenyl group optionally substituted by 1 to 3 substituents each independently selected from halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy;R.sup.1 is selected from (a) ##STR2## (b) --SO.sub.2 (C.sub.1 -C.sub.4 alkyl), (C) --SO.sub.2 NR.sup.2 R.sup.3 where either R.sup.2 and R.sup.3 are both C.sub.1 -C.sub.4 alkyl, or R.sup.2 and R.sup.3 together with the N atom to which they are attached represent piperidino, (d) --NHSO.sub.2 (C.sub.1 -C.sub.4 alkyl) and (e) --CONR.sup.4 R.sup.5 where either R.sup.4 is H or C.sub.1 -C.sub.4 alkyl and R.sup.5 is C.sub.1 -C.sub.4 alkyl, or R.sup.4 and R.sup.5 together with the N atom to which they are attached represent piperidino;and n is 1 or 2 with the proviso that n is 2 when R.sup.1 is --NHSO.sub.2 (C.sub.1 -C.sub.4 alkyl);and their pharmaceutically acceptable salts. The compounds are useful as human and agricultural fungicides.
    Type: Grant
    Filed: February 1, 1985
    Date of Patent: April 29, 1986
    Assignee: Pfizer Inc.
    Inventors: Geoffrey E. Gymer, Kenneth Richardson
  • Patent number: 4507484
    Abstract: Triazole antifungal agents of the formula: ##STR1## and their O-esters and O-ethers, where R is a phenyl group optionally substituted by 1 to 3 substituents each independently selected from halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; R.sup.1 is selected from (a) ##STR2## (C.sub.1 -C.sub.4 alkyl), (b) --SO.sub.2 (C.sub.1 -C.sub.4 alkyl), (C) --SO.sub.2 NR.sup.2 R.sup.3 where either R.sup.2 and R.sup.3 are both C.sub.1 -C.sub.4 alkyl, or R.sup.2 and R.sup.3 together with the N atom to which they are attached represent piperidino, (d) --NHSO.sub.2 (C.sub.1 -C.sub.4 alkyl) and (e) --CONR.sup.4 R.sup.5 where either R.sup.4 is H or C.sub.1 -C.sub.4 alkyl and R.sup.5 is C.sub.1 -C.sub.4 alkyl, or R.sup.4 and R.sup.5 together with the N atom to which they are attached represent piperidino;and n is 1 or 2 with the proviso that n is 2 when R.sup.1 is --NHSO.sub.2 (C.sub.1 -C.sub.4 alkyl);and their pharmaceutically acceptable salts. The compounds are useful as human and agricultural fungicides.
    Type: Grant
    Filed: May 31, 1983
    Date of Patent: March 26, 1985
    Assignee: Pfizer Inc.
    Inventors: Geoffrey E. Gymer, Kenneth Richardson
  • Patent number: 4435399
    Abstract: A series of novel 2-aryl-1-(imidazol-1-yl)-8-(4-piperazin-1-ylphenoxy)octan-2-ol derivatives has been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as antifungal agents for the treatment of various topical, mucosal and systemic fungal infections in animals, including humans. Preferred member compounds include 2-(2,4-dichlorophenyl)-1-(imidazol-1-yl)-8-[4-ethylpiperazin-1-yl)phenoxy] octan-2-ol, 2-(2,4-dichlorophenyl)-1-(imidazol-1-yl)-8-[4-(4-n-propylpiperazin-1-yl)ph enoxy]octan-2-ol and 2-(2,4-dichlorophenyl)-1-(imidazol-1-yl)-8-[4-(4-isopropylpiperazin-1-yl)p henoxy]octan-2-ol, respectively. Methods for preparing these compounds from known starting materials are provided.
    Type: Grant
    Filed: June 25, 1982
    Date of Patent: March 6, 1984
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Geoffrey E. Gymer
  • Patent number: 4107314
    Abstract: Novel 1-aryl-2-(1-imidazolyl)-alkyl sulphides having anti-fungal properties are disclosed.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: August 15, 1978
    Assignee: Pfeizer Inc.
    Inventors: David A. Cox, Geoffrey E. Gymer, Braham Shroot
  • Patent number: 4062966
    Abstract: Novel 1-aryl-2-(1-imidazolyl)alkyl ethers and thioethers having anti-fungal properties are disclosed.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: December 13, 1977
    Assignee: Pfizer Inc.
    Inventor: Geoffrey E. Gymer