Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: A row of a plurality of adjacent seats supported by a support frame. The seat includes a seat back, a seat pan and a leg rest. The leg rest of each seat includes a leg support surface and is mounted relative to the seat frame in a manner to allow it to move between (a) a stored condition and (b) a fully deployed condition where the seat pan and the leg rest support surface are substantially coplanar. The leg rest and seat pan of each seat in the row can cooperate to define a reconfigurable horizontal support surface for at least one passenger.

Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.

Abstract: A row of a plurality of adjacent seats supported by a support frame. The seat includes a seat back, a seat pan and a leg rest. The leg rest of each seat includes a leg support surface and is mounted relative to the seat frame in a manner to allow it to move between (a) a stored condition and (b) a fully deployed condition where the seat pan and the leg rest support surface are substantially coplanar. The leg rest and seat pan of each seat in the row can cooperate to define a reconfigurable horizontal support surface for at least one passenger.

Abstract: A row of a plurality of adjacent seats supported by a support frame. The seat includes a seat back, a seat pan and a leg rest. The leg rest of each seat includes a leg support surface and is mounted relative to the seat frame in a manner to allow it to move between (a) a stored condition and (b) a fully deployed condition where the seat pan and the leg rest support surface are substantially coplanar. The leg rest and seat pan of each seat in the row can cooperate to define a reconfigurable horizontal support surface for at least one passenger.

Abstract: The invention relates to an automated estimation of the position (co-ordinates) of a set of loudspeakers in a ioom Based on measured impulse responses the distances between each pair of loudspeakers are estimated, thereby forming a distance matrix, and the resultant distance matrix is used by a multidimensional scaling (MDS) algorithm to estimate the co-ordinates of each individual loudspeaker An improved co-ordinate estimation can, if desired, be derived by utilizing the stress values provided by the MDS algorithm.

Abstract: The invention relates to simulation of sound fields in enclosures, for instance for application in listening tests, where test subjects assess the sound quality or other sound perception characteristics of the sound field. According to a specific embodiment, the system comprises a binaural synthesis portion which synthesizes sound for instance from a sound-reproduction equipment based on measured impulse responses of an actual room stored in a data base (31) and a binaural recording portion comprising a data base 32 for storing binaural recordings of other sound signals made in the room. Data from these databases are mixed (41) and reproduced by means of a headphone (39) provided with a head tracker (42) for tracking the movements of the listener's head. The invention furthermore comprises the use of cross-fading functions (36, 37) to enable the dynamic listening conditions, where the movements of the listener's head are taken into account during the simulation process.

Abstract: A row of a plurality of adjacent seats supported by a support frame. The seat includes a seat back, a seat pan and a leg rest. The leg rest of each seat includes a leg support surface and is mounted relative to the seat frame in a manner to allow it to move between (a) a stored condition and (b) a fully deployed condition where the seat pan and the leg rest support surface are substantially coplanar. The leg rest and seat pan of each seat in the row can cooperate to define a reconfigurable horizontal support surface for at least one passenger.

Abstract: A row of a plurality of adjacent seats supported by a support frame. The seat includes a seat back, a seat pan and a leg rest. The leg rest of each seat includes a leg support surface and is mounted relative to the seat frame in a manner to allow it to move between (a) a stored condition and (b) a fully deployed condition where the seat pan and the leg rest support surface are substantially coplanar. The leg rest and seat pan of each seat in the row can cooperate to define a reconfigurable horizontal support surface for at least one passenger.

Abstract: Loudspeakers in domestic or automotive environments are rarely placed ideally with respect to the sources supplying them, and the stereo and surround images are seldom satisfying. According to the invention there is provided a method and apparatus for combining a precise knowledge about the relative positions of the loudspeakers that were intended (the virtual loudspeakers) and a precise knowledge about the actual placement of listening loudspeakers into a vector space that enables calculation of running corrections to the signals used in order to simulate the presence of the virtual loudspeakers. Specifically the corrections may comprise gain/attenuations determined based on the distances in vector space between the virtual and actual loudspeakers and delays determined from these distances.

Abstract: The present invention relates generally to sound reproduction systems and methods and more specifically to the reproduction of low-frequency signal components recorded in a Low Frequency Effects (LFE) channel.

Abstract: The invention relates to an automated estimation of the position (co-ordinates) of a set of loudspeakers in a room Based on measured impulse responses the distances between each pair of loudspeakers are estimated, thereby forming a distance matrix, and the resultant distance matrix is used by a multidimensional scaling (MDS) algorithm to estimate the co-ordinates of each individual loudspeaker An improved co-ordinate estimation can, if desired, be derived by utilising the stress values provided by the MDS algorithm.

Abstract: The invention relates to a method and system for reproduction of sound signals con-tained in a low frequency effect (LFE) channel in an audio reproduction system com-prising at least one main loudspeaker—although typically either five main loudspeakers in a surround sound system or two main loudspeakers in a traditional stereophonic system—and at least one low frequency loudspeaker (subwoofer) for reproduction of the lowest portion of the audible frequency range. According to the method and system of the present invention, the frequency range or the LFE channel is subdivided into a first frequency region below a given cutoff frequency, which first frequency region is provided to the subwoofer, and a second frequency region above said cut-off frequency, which second frequency region is provided to at least one of the main loudspeakers.

Abstract: Loudspeakers in domestic or automotive environments are rarely placed ideally with respect to the sources supplying them, and the stereo and surround images are seldom satisfying. According to the invention there is provided a method and apparatus for combining a precise knowledge about the relative positions of the loudspeakers that were intended (the virtual loudspeakers) and a precise knowledge about the actual placement of listening loudspeakers into a vector space that enables calculation of running corrections to the signals used in order to simulate the presence of the virtual loudspeakers. Specifically the corrections may comprise gain/attenuations determined based on the distances in vector space between the virtual and actual loudspeakers and delays determined from these distances.

Abstract: The invention relates to simulation of sound fields in enclosures, for instance for application in listening tests, where test subjects assess the sound quality or other sound perception characteristics of the sound field. According to a specific embodiment, the system comprises a binaural synthesis portion which synthesises sound for instance from a sound-reproduction equipment based on measured impulse responses of an actual room stored in a data base (31) and a binaural recording portion comprising a data base 32 for storing binaural recordings of other sound signals made in the room. Data from these databases are mixed (41) and reproduced by means of a headphone (39) provided with a head tracker (42) for tracking the movements of the listener's head. The invention furthermore comprises the use of cross-fading functions (36, 37) to enable the dynamic listening conditions, where the movements of the listener's head are taken into account during the simulation process.

Abstract: Typically, changes in timbre in an audio reproduction system use analogue or digital filters, either shelving filters (as in the case of bass, treble and loudness controllers) and/or peaking filters (as in the case of speed-and noise-compensation in automotive systems). A problem associated with this implementation lies in the audibility of the phase shift caused by these filters. According to the invention, this and further problems are solved by utilising the crossover network of the system itself—with level adjustable output signals—to attain desired timbre and/or dynamic range adjustments and hence avoiding undesirable phase effects of the traditional bass and treble control filters. An input signal (18) is according to an embodiment of the invention divided by a cross over network (20) into a number of frequency bands and applied via level control means (21, 22, 23) and separate power amplifiers (24, 25, 26) to loudspeaker drivers (27, 28, 29).