Patents by Inventor Geoffrey Hale

Geoffrey Hale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250206836
    Abstract: The claimed invention relates to treating cancer by targeting CD36, a fatty acid receptor. The claimed invention also relates to treating cancer metastases by targeting CD36. The invention involves using anti-CD36 antibodies as blockers or inhibitors of CD36 activity to treat or prevent cancer and/or metastatic cancer in a subject.
    Type: Application
    Filed: July 29, 2022
    Publication date: June 26, 2025
    Inventors: Salvador AZNAR BENITAH, Valerie VANHOOREN, Mercè DE FRIAS SÁNCHEZ, Beatriz MORANCHO ARMISEN, Salvador GUARDIOLA BAGÁN, Geoffrey HALE, Ian WILKINSON
  • Publication number: 20250002561
    Abstract: Provided are proteins comprising a variant IgG Fc region, wherein the proteins exhibit significantly reduced binding to human Fc?RI when compared with a reference protein comprising the amino acid substitutions L234A/L235A/P329G. Also provided are compositions, methods of treatment and methods to reduce Fc-induced effector functions in a parent protein.
    Type: Application
    Filed: June 11, 2024
    Publication date: January 2, 2025
    Inventors: Geoffrey Hale, Ian Wilkinson
  • Patent number: 12037380
    Abstract: Provided are proteins comprising a variant IgG Fc region, wherein the proteins exhibit significantly reduced binding to human Fc?RI when compared with a reference protein comprising the amino acid substitutions L234A/L235A/P329G. Also provided are compositions, methods of treatment and methods to reduce Fc-induced effector functions in a parent protein.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: July 16, 2024
    Assignee: MABSOL VE LIMITED
    Inventors: Geoffrey Hale, Ian Wilkinson
  • Publication number: 20230235013
    Abstract: Provided are proteins comprising a variant IgG Fc region, wherein the proteins exhibit significantly reduced binding to human Fc?RI when compared with a reference protein comprising the amino acid substitutions L234A/L235A/P329G. Also provided are compositions, methods of treatment and methods to reduce Fc-induced effector functions in a parent protein.
    Type: Application
    Filed: November 21, 2022
    Publication date: July 27, 2023
    Inventors: Geoffrey HALE, Ian Wilkinson
  • Publication number: 20230235073
    Abstract: The claimed invention relates to treating cancer by targeting CD36, a fatty acid receptor. The claimed invention also relates to treating cancer metastases by targeting CD36. The invention involves using anti-CD36 antibodies as blockers or inhibitors of CD36 activity.
    Type: Application
    Filed: March 5, 2021
    Publication date: July 27, 2023
    Applicant: ONA Therapeutics, S.L.
    Inventors: Salvador AZNAR BENITAH, Mercè DE FRIAS SÁNCHEZ, Salvador GUARDIOLA BAGÁN, Valerie VANHOOREN, Beatriz MORANCHO ARMISEN, Geoffrey HALE, Ian WILKINSON
  • Patent number: 8090841
    Abstract: The present invention is a method of doing business over a network that: receives a request for transmitting digital information after a start time and before an end time, determines the time required to transmit the digital information based on the number of packets in the information and the network speed, schedules a transmit time for the digital information, and accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time. Pricing of the transmission can be determined by the priority of transmission, whether the information is transmitted the first time or rescheduled, and whether the user receives an acknowledgment.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: January 3, 2012
    Assignee: International Business Machines Corporation
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, Jr.
  • Patent number: 7996545
    Abstract: The present invention is a computer system for delivering digital information over a network. A request receiving process receives a request for transmitting digital information after a start time and before an end time. The digital information has a number of packets. A transmit time process determines the time required to transmit the digital information based on the number of packets and a network speed. A scheduler schedules a transmit time for the digital information and an acceptance process accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: August 9, 2011
    Assignee: International Business Machines Corporation
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, Jr.
  • Patent number: 7830890
    Abstract: The present invention is a method of doing business over a network that: receives a request for transmitting digital information after a start time and before an end time, determines the time required to transmit the digital information based on the number of packets in the information and the network speed, schedules a transmit time for the digital information, and accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time. Pricing of the transmission can be determined by the priority of transmission, whether the information is transmitted the first time or rescheduled, and whether the user receives an acknowledgment.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: November 9, 2010
    Assignee: International Business Machines Corporation
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, Jr.
  • Publication number: 20090012876
    Abstract: The present invention is a method of doing business over a network that: receives a request for transmitting digital information after a start time and before an end time, determines the time required to transmit the digital information based on the number of packets in the information and the network speed, schedules a transmit time for the digital information, and accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time. Pricing of the transmission can be determined by the priority of transmission, whether the information is transmitted the first time or rescheduled, and whether the user receives an acknowledgment.
    Type: Application
    Filed: July 10, 2008
    Publication date: January 8, 2009
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, JR.
  • Publication number: 20090010177
    Abstract: The present invention is a computer system for delivering digital information over a network. A request receiving process receives a request for transmitting digital information after a start time and before an end time. The digital information has a number of packets. A transmit time process determines the time required to transmit the digital information based on the number of packets and a network speed. A scheduler schedules a transmit time for the digital information and an acceptance process accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time.
    Type: Application
    Filed: June 25, 2008
    Publication date: January 8, 2009
    Inventors: Norbert George VOGL, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, JR.
  • Publication number: 20080317026
    Abstract: The present invention is a method of doing business over a network that: receives a request for transmitting digital information after a start time and before an end time, determines the time required to transmit the digital information based on the number of packets in the information and the network speed, schedules a transmit time for the digital information, and accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time. Pricing of the transmission can be determined by the priority of transmission, whether the information is transmitted the first time or rescheduled, and whether the user receives an acknowledgment.
    Type: Application
    Filed: July 10, 2008
    Publication date: December 25, 2008
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clark, JR.
  • Publication number: 20080317037
    Abstract: The present invention is a method of doing business over a network that: receives a request for transmitting digital information after a start time and before an end time, determines the time required to transmit the digital information based on the number of packets in the information and the network speed, schedules a transmit time for the digital information, and accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time. Pricing of the transmission can be determined by the priority of transmission, whether the information is transmitted the first time or rescheduled, and whether the user receives an acknowledgment.
    Type: Application
    Filed: July 10, 2008
    Publication date: December 25, 2008
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, JR.
  • Patent number: 7403994
    Abstract: The present invention is a method of doing business over a network that: receives a request for transmitting digital information after a start time and before an end time, determines the time required to transmit the digital information based on the number of packets in the information and the network speed, schedules a transmit time for the digital information, and accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time. Pricing of the transmission can be determined by the priority of transmission, whether the information is transmitted the first time or rescheduled, and whether the user receives an acknowledgment.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: July 22, 2008
    Assignee: International Business Machines Corporation
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, Jr.
  • Patent number: 7150017
    Abstract: The present invention is a computer system for delivering digital information over a network. A request receiving process receives a request for transmitting digital information after a start time and before an end time. The digital information has a number of packets. A transmit time process determines the time required to transmit the digital information based on the number of packets and a network speed. A scheduler schedules a transmit time for the digital information and an acceptance process accepts the digital information for transmission only if the time required to transmit is less than or equal to the difference between the transmit time and the end time.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: December 12, 2006
    Assignee: International Business Machines Corporation
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, Jr.
  • Patent number: 6959327
    Abstract: A computer dispatcher connected to one or more respective network buffers has stored file lists that identify one or more of the files in the database that are to be transmitted over networks connected to the respective network buffer. A scheduler(s) schedule one or more portions of one or more of the files to be written to the respective network buffers by defining transmission criteria about each of the files in the file list. These transmission criteria include a quantity to transmit criteria, defining a quantity of one or more of the portions of the respective file to transmit, and one or more release times. The release times define the time at which the respective portion is to be written to the network buffer. The system includes a dispatching process that determines an available space on one or more of the network buffers and a current system time.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: October 25, 2005
    Assignee: International Business Machines Corporation
    Inventors: Norbert George Vogl, Geoffrey Hale Purdy, Robert Alan Flavin, Yuan Feng, Edward Payson Clarke, Jr.
  • Publication number: 20050118172
    Abstract: The invention relates to the use of an antibody recognising the CDw52 antigen in the treatment of multiple sclerosis. Preferably the antibody is the humanised antibody in the humanised antibody CAMPATH-1H.
    Type: Application
    Filed: September 13, 2004
    Publication date: June 2, 2005
    Inventors: Geoffrey Hale, Herman Waldmann
  • Publication number: 20050037004
    Abstract: Use of an aglycosylated antibody having a binding affinity for the CD3 antigen complex is provided for the manufacture of a medicament for treatment of chronic joint inflammation, and more particularly for treating Rheumatoid Arthritis.
    Type: Application
    Filed: September 26, 2002
    Publication date: February 17, 2005
    Applicant: Isis Innovation Limited
    Inventors: John Isaacs, Herman Waldmann, Geoffrey Hale
  • Patent number: 6291983
    Abstract: The invention is a broadband network monitoring system and method. The system has one or more RF carrier generators that generate one or more generator signals, called a reference signal, each of the generator signals having a generator signal frequency. One or more RF transient detectors sense a line signal on one or more broadband lines in the broadband network. Each line signal has one or more test signals applied by a remote RF carrier generator. Each test signal has a frequency equal to one of the reference signals. Each RF transient detector senses and compares the test signal and the reference signal in various ways to produce a transient indicator when the test signal and reference/generator signal are not the same. The transient indicator indicates that there may be a perturbation or some other problem in the respective broadband line. A controller is connected to each of the RF transient detectors and controls an RF switch and an analyzer.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: September 18, 2001
    Assignee: International Business Machines Corporation
    Inventors: Edward Payson Clarke, Jr., Robert Alan Flavin, Perwaiz Nihal, Geoffrey Hale Purdy, Norbert George Vogl
  • Patent number: 6205138
    Abstract: This invention is a broadband matrix switch system and method of operation. The broadband matrix switch has N number of broadband inputs, each of the broadband inputs having one or more broadband signals. The matrix switch has M number of broadband outputs. There are N number of splitters. Each of the splitters has a splitter input connected to one of the broadband inputs. Each of the splitters has M number of splitter outputs that produce the splitter output signal. There are N times M number of node switches. Each node switch is uniquely connected to one of the splitter outputs. The node switches have a control input that allows the node switch to pass the respective splitter output signal upon receiving a close command at the control input and to terminate the respective splitter output signal with an input impedance upon receiving an open command at the control input. There are M number of combiners. Each combiner has a combiner output connected to one of the broadband outputs.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: March 20, 2001
    Assignee: International Business Machines Corporation
    Inventors: Perwaiz Nihal, Robert Alan Flavin, Thompson Baum Vesecky, Norbert George Vogl, Edward Payson Clarke, Jr., Luis Rodriguez-Cortes, Geoffrey Hale Purdy
  • Patent number: 6120766
    Abstract: The invention relates to the use of an antibody recognizing the Cdw52 antigen in the treatment of multiple sclerosis. Preferably, the antibody is the humanized antibody in the humanized antibody CAMPATH-1H.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: September 19, 2000
    Inventors: Geoffrey Hale, Herman Waldmann