Patents by Inventor Geoffrey L. Curran

Geoffrey L. Curran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting parenchymal plaques in vivo
    Patent number: 7371365
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated ?-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: May 13, 2008
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack
  • Amino acid composition with increased blood brain barrier permeability
    Patent number: 7279149
    Abstract: An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or glutamyl-4-aminobutane residue.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: October 9, 2007
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack, Daniel J. McCormick, Abdul H. Fauq
  • Methods for detecting parenchymal plaques in vivo
    Publication number: 20040022736
    Abstract: Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated &bgr;-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
    Type: Application
    Filed: January 27, 2003
    Publication date: February 5, 2004
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran, Thomas M. Wengenack
  • Method to enhance permeability of the blood/brain blood/nerve bariers to therapeutic agents
    Patent number: 5670477
    Abstract: A method is provided to enhance the ability of a neurologically active compound to penetrate the blood nerve barrier (BNB) or blood brain barrier (BBB), by administration of a conjugate comprising the neurologically active compound linked to a carrier molecule that has been shown to have a substantial permeability coefficient across the BNB and BBB.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: September 23, 1997
    Assignees: Joseph F. Poduslo, Geoffrey L. Curran
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran
  • Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents
    Patent number: 5604198
    Abstract: A method is provided to enhance the ability of a neurologically active compound to penetrate the blood nerve barrier (BNB) or blood brain barrier (BBB), by administration of a conjugate comprising the neurologically active compound linked to a carrier molecule that has been shown to have a substantial permeability coefficient across the BNB and BBB.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 18, 1997
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran
  • Method to increase permeability of the blood-nerve/brain barriers to proteins
    Patent number: 5260308
    Abstract: A method is provided to enhance the permeability of the blood-nerve barrier or the blood-brain barrier to neuroactive proteins, comprising glycating said proteins prior to bringing them into contact with said barriers.
    Type: Grant
    Filed: November 6, 1991
    Date of Patent: November 9, 1993
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Joseph F. Poduslo, Geoffrey L. Curran