Patents by Inventor Geoffrey L. Smith

Geoffrey L. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERFERON ANTAGONISTS, ANTIBODIES THERETO, AND ASSOCIATED METHODS OF USE
    Publication number: 20150139999
    Abstract: Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 21, 2015
    Inventors: Sergei V. Kotenko, Geoffrey L. Smith
  • Interferon antagonists, antibodies thereto and associated methods of use
    Patent number: 8771700
    Abstract: Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: July 8, 2014
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Sergei V. Kotenko, Geoffrey L. Smith
  • METHODS AND REAGENTS FOR VACCINATION WHICH GENERATE A CD8 T CELL IMMUNE RESPONSE
    Publication number: 20110159034
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: November 5, 2010
    Publication date: June 30, 2011
    Inventors: Andrew McMICHAEL, Adrian V.S. Hill, Sarah C. Gilbert, Jörg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • INTERFERON ANTAGONISTS, ANTIBODIES THERETO AND ASSOCIATED METHODS OF USE
    Publication number: 20110027282
    Abstract: Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.
    Type: Application
    Filed: August 23, 2007
    Publication date: February 3, 2011
    Inventors: Sergei V. Kotenko, Geoffrey L. Smith
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20100119551
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: June 19, 2009
    Publication date: May 13, 2010
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20090324632
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: May 15, 2009
    Publication date: December 31, 2009
    Applicant: Oxxon Therapeutics Ltd.
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for vaccination which generate A CD8 T cell immune response
    Publication number: 20090191237
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: August 4, 2008
    Publication date: July 30, 2009
    Applicant: Oxxon Therapeutics Limited
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for immunization which generate a CD8 T cell immune response
    Patent number: 7514087
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumor antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: April 7, 2009
    Assignee: Oxxon Therapeutics Limited
    Inventors: Andrew McMichael, Adrian V. S. Hill, Sarah C. Gilbert, Jörg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents that generate a CD8 T cell immune response
    Patent number: 7407661
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: August 5, 2008
    Assignee: Oxxon Therapeutics Limited
    Inventors: Andrew McMichael, Adrian V. S. Hill, Sarah C. Gilbert, Jörg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods of immunization using recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
    Patent number: 7045136
    Abstract: Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses also are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 16, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey L. Smith
  • Compositions containing recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
    Patent number: 7015024
    Abstract: Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses, also are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 21, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey L. Smith
  • Recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences
    Patent number: 6998252
    Abstract: Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses also are provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 14, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Bernard Moss, Michael Mackett, Geoffrey L. Smith
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20040213799
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: October 16, 2003
    Publication date: October 28, 2004
    Applicant: Oxxon Pharmaccines Limited
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20040197349
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: April 28, 2004
    Publication date: October 7, 2004
    Applicant: Oxxon Therapeutics Ltd.
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20040191272
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: April 28, 2004
    Publication date: September 30, 2004
    Applicant: Oxxon Therapeutics Ltd.
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20040175365
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: April 28, 2004
    Publication date: September 9, 2004
    Applicant: Oxxon Therapeutics Ltd.
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Low-complexity DMT transceiver
    Patent number: 6771695
    Abstract: A DMT signal conforming to a first DMT standard (e.g., the full-rate G.dmt standard based on 255 tones) is sampled at a sampling rate for the first DMT standard, filtered to attenuate a subset of the tones of the first DMT standard (e.g., all G.dmt tones above tone #127), and subsampled (e.g., 2:1) to provide a subsampled, filtered signal that can be further processed using components designed to operate under a second, different DMT standard (e.g., the half-rate G.lite standard based on 127 tones). As such, a conventional half-rate G.lite DMT transceiver can be modified (e.g., by changing the downstream sampling rate from 1.104 MHz to 2.208 MHz and adding an appropriate low-pass filter and decimator) for configuration in a full-rate G.dmt DMT system.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: August 3, 2004
    Assignee: Agere Systems Inc.
    Inventors: Raja Banerjea, Bahman Barazesh, Yhean-Sen Lai, Kannan Rajamani, Geoffrey L. Smith
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Publication number: 20040131594
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Application
    Filed: September 2, 2003
    Publication date: July 8, 2004
    Inventors: Andrew McMichael, Adrian V.S. Hill, Sarah C. Gilbert, Jorg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard
  • Methods and reagents for vaccination which generate a CD8 T cell immune response
    Patent number: 6663871
    Abstract: New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: December 16, 2003
    Assignee: Oxxon Pharmaccines Ltd.
    Inventors: Andrew McMichael, Adrian V. S. Hill, Sarah C. Gilbert, Jörg Schneider, Magdalena Plebanski, Tomas Hanke, Geoffrey L. Smith, Tom Blanchard