Patents by Inventor Geoffrey LOWMAN
Geoffrey LOWMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250188645Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: January 3, 2025Publication date: June 12, 2025Inventors: Geoffrey Lowman, Timothy Looney, Lifeng Lin, Elizabeth Linch, Lauren Miller
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Patent number: 12227878Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: GrantFiled: May 7, 2021Date of Patent: February 18, 2025Assignee: Life Technologies CorporationInventors: Geoffrey Lowman, Timothy Looney, Lifeng Lin, Elizabeth Linch, Lauren Miller
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Publication number: 20250019864Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: March 15, 2024Publication date: January 16, 2025Inventors: Timothy Looney, Geoffrey Lowman, Lifeng Lin
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Patent number: 11970787Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: GrantFiled: February 4, 2021Date of Patent: April 30, 2024Assignee: Life Technologies CorporationInventors: Timothy Looney, Geoffrey Lowman, Lifeng Lin
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Publication number: 20230416810Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of B cell receptor heavy and light chains in a single assay, with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: May 15, 2023Publication date: December 28, 2023Applicant: Life Technologies CorporationInventors: Geoffrey Lowman, Chenchen Yang, Timothy Looney
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Publication number: 20230340602Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, methods provide for determining convergence of T cell receptor beta and T cell receptor gamma repertoires in samples prior to a treatment and predicting a subject's response to the treatment. In another aspect, methods provide predicting a subject's potential or predisposition to be protected from or vulnerable to an adverse event following a treatment.Type: ApplicationFiled: May 16, 2023Publication date: October 26, 2023Applicant: Life Technologies CorporationInventors: Geoffrey Lowman, Chenchen Yang, Timothy Looney
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Publication number: 20230131285Abstract: Prediction of a clinical response to a therapy of a subject with an autoimmune disease based on B cell immune repertoire may include determining a plurality of clone frequencies in a biological sample from the subject, wherein the clone frequencies include: IgM, IgD, IgG3, IgG4, IgA, IgM with first somatic hypermutation (SHM) level, IgG1 with second SHM level. A plurality of decision criteria may be applied to features including the plurality of clone frequencies. Each decision criterion applies at least one threshold to a feature, wherein the plurality of decision criteria provides a plurality of output values. The plurality of output values may be summed and a sigmoid transformation may be applied to the summed value to form a prediction value. The prediction value may be compared to a final threshold to identify the subject as a likely responder or non-responder to an autoimmune disease therapy.Type: ApplicationFiled: August 17, 2022Publication date: April 27, 2023Inventors: Shrutii SARDA, Geoffrey LOWMAN
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Publication number: 20220073983Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of nucleic acid sequences of murine T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: July 18, 2019Publication date: March 10, 2022Inventors: Timothy LOONEY, Chenchen YANG, Geoffrey LOWMAN
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Publication number: 20220002802Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: July 18, 2019Publication date: January 6, 2022Inventors: Timothy LOONEY, Geoffrey LOWMAN, Lifeng LIN, Chenchen YANG
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Publication number: 20210285027Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: May 7, 2021Publication date: September 16, 2021Inventors: Geoffrey LOWMAN, Timothy LOONEY, Lifeng LIN, Elizabeth LINCH, Lauren MILLER
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Publication number: 20210164047Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: February 4, 2021Publication date: June 3, 2021Inventors: Timothy LOONEY, Geoffrey LOWMAN, Lifeng LIN
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Patent number: 11008609Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: GrantFiled: August 31, 2018Date of Patent: May 18, 2021Assignee: Life Technologies CorporationInventors: Geoffrey Lowman, Timothy Looney, Lifeng Lin, Elizabeth Linch, Lauren Miller
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Patent number: 10920273Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: GrantFiled: January 17, 2018Date of Patent: February 16, 2021Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Timothy Looney, Geoffrey Lowman, Lifeng Lin
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Publication number: 20190085374Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire using genomic DNA from a biological sample. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Nucleic acid sequences of variable regions associated with the immune cell receptor are determined to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: August 31, 2018Publication date: March 21, 2019Inventors: Geoffrey LOWMAN, Timothy LOONEY, Lifeng LIN, Elizabeth LINCH, Lauren MILLER
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Publication number: 20180208984Abstract: The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.Type: ApplicationFiled: January 17, 2018Publication date: July 26, 2018Inventors: Timothy LOONEY, Geoffrey LOWMAN, Lifeng LIN