Patents by Inventor Geoffrey Lynn

Geoffrey Lynn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210023208
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Application
    Filed: October 6, 2020
    Publication date: January 28, 2021
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
  • Publication number: 20210000934
    Abstract: The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.
    Type: Application
    Filed: June 22, 2020
    Publication date: January 7, 2021
    Applicants: Oxford University Innovation Limited, The U.S.A., as Represented by the Secretary, Department of Health and Human Services
    Inventors: Kerry Fisher, Richard Laga, Geoffrey Lynn, Leonard Seymour, Robert Seder
  • Patent number: 10799580
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 13, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
  • Publication number: 20190060435
    Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.
    Type: Application
    Filed: February 27, 2017
    Publication date: February 28, 2019
    Applicant: The United States of America, as represented by the Secretary, Dept of Health and Human Service
    Inventors: Robert Seder, Geoffrey Lynn
  • Publication number: 20180280497
    Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.
    Type: Application
    Filed: September 9, 2016
    Publication date: October 4, 2018
    Applicants: The Chancellor, Masters and Scholars of the University of Oxford
    Inventors: Robert SEDER, Geoffrey LYNN, Leonard SEYMOUR
  • Publication number: 20170304420
    Abstract: The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.
    Type: Application
    Filed: October 9, 2015
    Publication date: October 26, 2017
    Applicants: Oxford University Innovation Limited, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV
    Inventors: Kerry Fisher, Richard Laga, Geoffrey Lynn, Leonard Seymour, Robert Seder
  • Patent number: 9127237
    Abstract: A surfactant composition comprising alkylarylsulfonate molecules wherein more than 30 wt. % of the alkylarylsulfonate molecules of the surfactant composition are species of the formula: [R—X—Ar(SO3)?]a[Mn+]b wherein: X is a linear acyclic aliphatic hydrocarbyl chain; R is bound to a non-terminal carbon atom of X and is selected from H and C1 to C3 alkyl groups; X and R together have 10 or less carbon atoms, preferably 9 or 10 carbon atoms, most preferably 10 carbon atoms; Ar is an aromatic group; M is a cation or cation mixture, n is selected from 1, 2 and 3; and a and b are selected such that the alkylarylsulfonate molecule is electroneutral.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 8, 2015
    Assignee: Sasol Germany GmbH
    Inventors: Burkhard Breitzke, Britta Jakobs-Sauter, Clemens Schröder, Udo Schoenkaes, Giuseppe Giuffrida, Lee Matheson, Kermit Kinsley, Michael Cox, Geoffrey Lynn Russell, John Barry Winder
  • Patent number: 8620485
    Abstract: An electronic tag (8) displays and monitors a maintenance state of an associated electrically-powered device. The tag includes data storage (2) for storing data indicative of the maintenance state, the data comprising information defining an expiry date for the maintenance state. A data processing unit (3) monitors a remaining duration to the expiry date and a display (4) displays information indicative of the maintenance state. A cut-out unit (7) controllably enables transmission of electrical power to the associated electrically powered device dependent on the remaining duration.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: December 31, 2013
    Assignee: IntaCept Pty., Ltd.
    Inventors: Jan Huibert Vander Hout, Mark Geoffrey Lynn, Geoffrey Scott Knagge
  • Publication number: 20130005626
    Abstract: A surfactant composition comprising alkylarylsulfonate molecules wherein more than 30 wt. % of the alkylarylsulfonate molecules of the surfactant composition are species of the formula: [R—X—Ar(SO3)?]a[Mn+]b wherein: X is a linear acyclic aliphatic hydrocarbyl chain; R is bound to a non-terminal carbon atom of X and is selected from H and C1 to C3 alkyl groups; X and R together have 10 or less carbon atoms, preferably 9 or 10 carbon atoms, most preferably 10 carbon atoms; Ar is an aromatic group; M is a cation or cation mixture, n is selected from 1, 2 and 3; and a and b are selected such that the alkylarylsulfonate molecule is electroneutral.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 3, 2013
    Inventors: Burkhard Breitzke, Britta Jakobs-Sauter, Clemens Schröder, Udo Schoenkaes, Giuseppe Giuffrida, Lee Matheson, Kermit Kinsley, Michael Cox, Geoffrey Lynn Russell, John Barry Winder
  • Publication number: 20110153112
    Abstract: An electronic tag (8) displays and monitors a maintenance state of an associated electrically-powered device. The tag includes data storage (2) for storing data indicative of the maintenance state, the data comprising information defining an expiry date for the maintenance state. A data processing unit (3) monitors a remaining duration to the expiry date and a display (4) displays information indicative of the maintenance state. A cut-out unit (7) controllably enables transmission of electrical power to the associated electrically powered device dependent on the remaining duration.
    Type: Application
    Filed: August 8, 2008
    Publication date: June 23, 2011
    Applicant: INTA HOLDINGS PTY LIMITED
    Inventors: Jan Huibert Vander Hout, Mark Geoffrey Lynn, Geoffrey Scott Knagge
  • Patent number: 7755755
    Abstract: A method is provided for identifying a contaminant in a gaseous space. The method includes: generating a broadband optical waveform; shaping the optical waveform to match an expected waveform for a known contaminant; and transmitting the shaped optical waveform towards an unknown contaminant. Upon receiving a reflected optical waveform from the unknown contaminant, determining whether the unknown contaminant correlates to the known contaminant based on the reflected waveform.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: July 13, 2010
    Assignees: Harris Corporation, Lucents Technologies Inc., University of Central Florida Foundations, Inc.
    Inventors: John Richard DeSalvo, Geoffrey Lynn Burdge, Bruce W. FitzGerald, Young-Kai Chen, Andreas Leven, Peter Delfyett
  • Publication number: 20080195335
    Abstract: A method is provided for identifying a contaminant in a gaseous space. The method includes: generating a broadband optical waveform; shaping the optical waveform to match an expected waveform for a known contaminant; and transmitting the shaped optical waveform towards an unknown contaminant. Upon receiving a reflected optical waveform from the unknown contaminant, determining whether the unknown contaminant correlates to the known contaminant based on the reflected waveform.
    Type: Application
    Filed: February 14, 2007
    Publication date: August 14, 2008
    Inventors: John Richard DeSalvo, Geoffrey Lynn Burdge, Bruce W. FitzGerald, Young-Kai Chen, Andreas Leven, Peter Delfyett
  • Patent number: 6505884
    Abstract: A lower fender extension brace for mounting on truck hood fenders to prevent lower fender breakage and cracking. Lower fender extension brace comprises brace attachable to the inside of a hood fender of a truck or van to provide support to the front, corner, and side of said hood fender to reduce breaking and cracking in the hood fender. Lower fender extension brace that can be attached to the inside of a hood fender of a truck or van using rivets, nuts and bolts, molecular bonding, or high strength bonding tape.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: January 14, 2003
    Inventors: Geoffrey Lynn Phillips, Michael Dale Rhodes
  • Publication number: 20020141041
    Abstract: A method of an apparatus for compensating optical non-linearity in optical devices and transmission systems. Two second order interactions are cascaded in phase-mismatched second harmonic generation to accumulate a non-linear phase shift of a fundamental wave. The non-linear phase shift can be set to provide a desired amount of non-linearity compensation. Compensation takes place in a compensating medium having a negative effective non-linear refractive index at the design operating conditions of the compensating medium. Compensators incorporating these principles may be incorporated as passive or active components in optical transmitters, repeaters or receivers. Active components may be tuned by varying the operating condition of the compensating medium, for example by controlling temperature or applied stress.
    Type: Application
    Filed: August 10, 2001
    Publication date: October 3, 2002
    Inventors: David Neil Payne, Shaif-Ul Alam, Geoffrey Lynn Burdge, Anatoly Borisovich Grudinin
  • Publication number: 20020000729
    Abstract: A lower fender extension brace for mounting on truck hood fenders to prevent lower fender breakage and cracking.
    Type: Application
    Filed: May 15, 2001
    Publication date: January 3, 2002
    Inventors: Geoffrey Lynn Phillips, Michael Dale Rhodes