Patents by Inventor Geoffrey Lynn
Geoffrey Lynn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11951212Abstract: The present invention features compositions comprising a plurality of therapeutic agents wherein the presence of one therapeutic agent enhances the properties of at least one other therapeutic agent. In one embodiment, the therapeutic agents are cystic fibrosis transmembrane conductance regulators (CFTR) such as a CFTR corrector or CFTR potentiator for the treatment of CFTR mediated diseases such as cystic fibrosis. Methods and kits thereof are also disclosed.Type: GrantFiled: March 17, 2021Date of Patent: April 9, 2024Assignee: Vertex Pharmaceuticals IncorporatedInventors: Brian Dean Phenix, Laurent Jean-Claude Bagnol, Geoffrey Glen Brodeur, Sachin Chandran, Eleni Dokou, Lori Ann Ferris, Dragutin Knezic, Katie Lynn McCarty, Ales Medek, Sara A. Waggener
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Patent number: 11938177Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.Type: GrantFiled: November 2, 2021Date of Patent: March 26, 2024Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: Robert Seder, Geoffrey Lynn
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Publication number: 20230026627Abstract: A star polymer of formula O[P1]-([X]-A[P2]-[Z]-[P3])n where O is a core; A is a polymer arm attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and P3; P1, P2 and P3 are each independently one or more pharmaceutically active compounds that act extracellularly or intracellularly, n is an integer number; [ ] denotes that the group is optional; and at least one of P1, P2 or P3 is present.Type: ApplicationFiled: April 16, 2020Publication date: January 26, 2023Applicants: Vaccitech North America, Inc., Institute of Macromolecular Chemistry, The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Geoffrey Lynn, Yaling Zhu, Jacob Holechek, David Wilson, Joe Francica, Richard Laga, Gabriela Muzíková
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Publication number: 20220152170Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.Type: ApplicationFiled: November 2, 2021Publication date: May 19, 2022Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServicInventors: Robert Seder, Geoffrey Lynn
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Patent number: 11191821Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.Type: GrantFiled: February 27, 2017Date of Patent: December 7, 2021Assignee: The United States of America as represented by the Secretary, Department of Health and Human ServicesInventors: Robert Seder, Geoffrey Lynn
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Publication number: 20210023208Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.Type: ApplicationFiled: October 6, 2020Publication date: January 28, 2021Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Servic, The Chancellor, Masters and Scholars of the University of OxfordInventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
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Publication number: 20210000934Abstract: The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.Type: ApplicationFiled: June 22, 2020Publication date: January 7, 2021Applicants: Oxford University Innovation Limited, The U.S.A., as Represented by the Secretary, Department of Health and Human ServicesInventors: Kerry Fisher, Richard Laga, Geoffrey Lynn, Leonard Seymour, Robert Seder
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Patent number: 10799580Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.Type: GrantFiled: September 9, 2016Date of Patent: October 13, 2020Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Chancellor, Masters and Scholars of the University of OxfordInventors: Robert Seder, Geoffrey Lynn, Leonard Seymour
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Publication number: 20190060435Abstract: Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.Type: ApplicationFiled: February 27, 2017Publication date: February 28, 2019Applicant: The United States of America, as represented by the Secretary, Dept of Health and Human ServiceInventors: Robert Seder, Geoffrey Lynn
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Publication number: 20180280497Abstract: Embodiments of a novel system for delivering an expression vector encoding an antigen to a subject that allows for spatiotemporal control over stimulation of the subject's immune response to the antigen are provided. In some embodiments, the expression vector delivery system includes a polymer linked to an adjuvant in prodrug form that can form polymer nanoparticles and enter a cell (such as an immune cell) under physiological conditions. In some embodiments, the adjuvant is linked to the polymer by an enzyme degradable labile bond, the cleavage of which activates the adjuvant to stimulate an immune response.Type: ApplicationFiled: September 9, 2016Publication date: October 4, 2018Applicants: The Chancellor, Masters and Scholars of the University of OxfordInventors: Robert SEDER, Geoffrey LYNN, Leonard SEYMOUR
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Publication number: 20170304420Abstract: The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.Type: ApplicationFiled: October 9, 2015Publication date: October 26, 2017Applicants: Oxford University Innovation Limited, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVInventors: Kerry Fisher, Richard Laga, Geoffrey Lynn, Leonard Seymour, Robert Seder
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Patent number: 9127237Abstract: A surfactant composition comprising alkylarylsulfonate molecules wherein more than 30 wt. % of the alkylarylsulfonate molecules of the surfactant composition are species of the formula: [R—X—Ar(SO3)?]a[Mn+]b wherein: X is a linear acyclic aliphatic hydrocarbyl chain; R is bound to a non-terminal carbon atom of X and is selected from H and C1 to C3 alkyl groups; X and R together have 10 or less carbon atoms, preferably 9 or 10 carbon atoms, most preferably 10 carbon atoms; Ar is an aromatic group; M is a cation or cation mixture, n is selected from 1, 2 and 3; and a and b are selected such that the alkylarylsulfonate molecule is electroneutral.Type: GrantFiled: June 28, 2011Date of Patent: September 8, 2015Assignee: Sasol Germany GmbHInventors: Burkhard Breitzke, Britta Jakobs-Sauter, Clemens Schröder, Udo Schoenkaes, Giuseppe Giuffrida, Lee Matheson, Kermit Kinsley, Michael Cox, Geoffrey Lynn Russell, John Barry Winder
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Patent number: 8620485Abstract: An electronic tag (8) displays and monitors a maintenance state of an associated electrically-powered device. The tag includes data storage (2) for storing data indicative of the maintenance state, the data comprising information defining an expiry date for the maintenance state. A data processing unit (3) monitors a remaining duration to the expiry date and a display (4) displays information indicative of the maintenance state. A cut-out unit (7) controllably enables transmission of electrical power to the associated electrically powered device dependent on the remaining duration.Type: GrantFiled: August 8, 2008Date of Patent: December 31, 2013Assignee: IntaCept Pty., Ltd.Inventors: Jan Huibert Vander Hout, Mark Geoffrey Lynn, Geoffrey Scott Knagge
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Publication number: 20130005626Abstract: A surfactant composition comprising alkylarylsulfonate molecules wherein more than 30 wt. % of the alkylarylsulfonate molecules of the surfactant composition are species of the formula: [R—X—Ar(SO3)?]a[Mn+]b wherein: X is a linear acyclic aliphatic hydrocarbyl chain; R is bound to a non-terminal carbon atom of X and is selected from H and C1 to C3 alkyl groups; X and R together have 10 or less carbon atoms, preferably 9 or 10 carbon atoms, most preferably 10 carbon atoms; Ar is an aromatic group; M is a cation or cation mixture, n is selected from 1, 2 and 3; and a and b are selected such that the alkylarylsulfonate molecule is electroneutral.Type: ApplicationFiled: June 28, 2011Publication date: January 3, 2013Inventors: Burkhard Breitzke, Britta Jakobs-Sauter, Clemens Schröder, Udo Schoenkaes, Giuseppe Giuffrida, Lee Matheson, Kermit Kinsley, Michael Cox, Geoffrey Lynn Russell, John Barry Winder
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Publication number: 20110153112Abstract: An electronic tag (8) displays and monitors a maintenance state of an associated electrically-powered device. The tag includes data storage (2) for storing data indicative of the maintenance state, the data comprising information defining an expiry date for the maintenance state. A data processing unit (3) monitors a remaining duration to the expiry date and a display (4) displays information indicative of the maintenance state. A cut-out unit (7) controllably enables transmission of electrical power to the associated electrically powered device dependent on the remaining duration.Type: ApplicationFiled: August 8, 2008Publication date: June 23, 2011Applicant: INTA HOLDINGS PTY LIMITEDInventors: Jan Huibert Vander Hout, Mark Geoffrey Lynn, Geoffrey Scott Knagge
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Patent number: 7755755Abstract: A method is provided for identifying a contaminant in a gaseous space. The method includes: generating a broadband optical waveform; shaping the optical waveform to match an expected waveform for a known contaminant; and transmitting the shaped optical waveform towards an unknown contaminant. Upon receiving a reflected optical waveform from the unknown contaminant, determining whether the unknown contaminant correlates to the known contaminant based on the reflected waveform.Type: GrantFiled: February 14, 2007Date of Patent: July 13, 2010Assignees: Harris Corporation, Lucents Technologies Inc., University of Central Florida Foundations, Inc.Inventors: John Richard DeSalvo, Geoffrey Lynn Burdge, Bruce W. FitzGerald, Young-Kai Chen, Andreas Leven, Peter Delfyett
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Publication number: 20080195335Abstract: A method is provided for identifying a contaminant in a gaseous space. The method includes: generating a broadband optical waveform; shaping the optical waveform to match an expected waveform for a known contaminant; and transmitting the shaped optical waveform towards an unknown contaminant. Upon receiving a reflected optical waveform from the unknown contaminant, determining whether the unknown contaminant correlates to the known contaminant based on the reflected waveform.Type: ApplicationFiled: February 14, 2007Publication date: August 14, 2008Inventors: John Richard DeSalvo, Geoffrey Lynn Burdge, Bruce W. FitzGerald, Young-Kai Chen, Andreas Leven, Peter Delfyett
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Patent number: 6505884Abstract: A lower fender extension brace for mounting on truck hood fenders to prevent lower fender breakage and cracking. Lower fender extension brace comprises brace attachable to the inside of a hood fender of a truck or van to provide support to the front, corner, and side of said hood fender to reduce breaking and cracking in the hood fender. Lower fender extension brace that can be attached to the inside of a hood fender of a truck or van using rivets, nuts and bolts, molecular bonding, or high strength bonding tape.Type: GrantFiled: May 15, 2001Date of Patent: January 14, 2003Inventors: Geoffrey Lynn Phillips, Michael Dale Rhodes
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Publication number: 20020141041Abstract: A method of an apparatus for compensating optical non-linearity in optical devices and transmission systems. Two second order interactions are cascaded in phase-mismatched second harmonic generation to accumulate a non-linear phase shift of a fundamental wave. The non-linear phase shift can be set to provide a desired amount of non-linearity compensation. Compensation takes place in a compensating medium having a negative effective non-linear refractive index at the design operating conditions of the compensating medium. Compensators incorporating these principles may be incorporated as passive or active components in optical transmitters, repeaters or receivers. Active components may be tuned by varying the operating condition of the compensating medium, for example by controlling temperature or applied stress.Type: ApplicationFiled: August 10, 2001Publication date: October 3, 2002Inventors: David Neil Payne, Shaif-Ul Alam, Geoffrey Lynn Burdge, Anatoly Borisovich Grudinin
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Publication number: 20020000729Abstract: A lower fender extension brace for mounting on truck hood fenders to prevent lower fender breakage and cracking.Type: ApplicationFiled: May 15, 2001Publication date: January 3, 2002Inventors: Geoffrey Lynn Phillips, Michael Dale Rhodes