Abstract: A jet vectoring apparatus has a nozzle (1) which comprises a throat aperture (8) and an exit aperture (9), the apparatus also having a post exit surface (10). Variation of at least one of the throat aperture (8), exit aperture (9) and post exit surface causes a pressure differential upon the post exit surface which permits the direction of propulsive jet flow (3) (also known as jet thrust) to be varied relative to the longitudinal axis (2) of the apparatus.

Abstract: A star polymer of formula O[D1]-([X]-A(D2)-[Z]-[D3])n where O is a core; A is a polymer arm that comprises reactive monomers, hydrophilic monomers and/or charged monomers and is attached to the core; X is a linker molecule between the core and the polymer arm; Z is a linker molecule between the end of the polymer arm and D3; D1 is a drug molecule linked to the core; D2 is a drug molecule linked to reactive monomers distributed along the polymer arm; D3 is a drug molecule linked to the ends of the polymer arms; n is an integer number; [ ] denotes that the group is optional; and D2 is linked to the reactive monomers distributed along the polymer arm at a density of between 1 mol % and 80 mol %.

Abstract: An amphiphilic block copolymer having any one of the formulas D-S—H, S(D)-H, S—H(D), D-S—H—S, D-S—H—S-D, S(D)-H—S, S(D)-H—S(D) or S—H(D)-S is disclosed. S is a hydrophilic block; H is a hydrophobic block; D is a drug molecule; ( ) denotes that the group is bonded directly or indirectly as a side chain or as part of a side chain group to the adjacent group; and the hyphen, “-” (or sometimes “-”), denotes that each of the adjacent S, H or D are linked either directly to one another or indirectly to one another via a linker, additionally wherein the hydrophilic block comprises a first hydrophilic monomer and the hydrophobic block comprises a first hydrophobic monomer and a second hydrophobic monomer.

Abstract: Provided herein is a method for inducing an immune response to at least one neoantigen, the method comprising administering to a subject a priming composition comprising a peptide antigen conjugate and at least a first boost. The first boost comprises a first oncolytic virus comprising a genome that expresses a first peptide or a second peptide, wherein the first and second peptide are each capable of inducing an immune response to at least one neoantigen. The method further comprises administering the subject a second boost, comprising a second oncolytic virus comprising a genome that expresses a third peptide or a fourth peptide, wherein the third peptide and the fourth peptide are each capable of inducing an immune response to at least one neoantigen, and wherein the second oncolytic virus is immunologically distinct from the first oncolytic virus. The subject may have pre-existing immunity to the at least one neoantigen.

Abstract: An appliance for making a drink individually. The appliance includes a plurality of containers. Each container includes a vessel and a head screwed onto the vessel. A base defines a plurality of housings each receiving a container, and being provided with a housing outlet and a pressurizing inlet connected with a drain valve and a pressurizing valve of the container, respectively. A funnel is mounted under the housing outlets. Structure transfers by pressurization, into the funnel, ingredients contained in the containers housed in the housings. The vessel and the head of at least one container include polarizing surfaces of the vessel and of the head, respectively, configured to form, together, a container polarizing surface that can cooperate with a housing polarizing surface to ensure a predetermined positioning of the container with respect to the housing.

Abstract: An amphiphilic block copolymer having any one of the formulas S-[B]-H, S-[B]-H(D), D-[B]-H, S-B(D)-H, S-[B]-H-[B]-S, S-[B]-H(D)-[B]-S, D-[B]-H-[B]-S, D-[B]-H-[B]-D, S-B(D)-H-[B]-S or S-B(D)-H-B(D)-S; wherein S is a hydrophilic surface stabilizing group; B is a spacer group; H is a hydrophobic polymer or oligomer; D is a drug molecule; ( ) denotes that the group is bonded directly or indirectly as a side chain or as part of a side chain group to the adjacent group; [ ] denotes that the group is optional; and - denotes that each of the adjacent S, B, H or D are linked directly to one another or indirectly to one another via a linker group.

Abstract: A machine for making an individual drink. The machine includes a pressure source, a store defining a plurality of housings, a plurality of removable containers each immobilized, in a service position, in a respective housing. Each container includes a receptacle containing an ingredient, and an upstream emptying valve allowing the ingredient to be caused to exit to the outside of the receptacle by an increased pressure generated inside the receptacle by the pressure source. The machine includes a chamber to receive the ingredients extracted from the containers, via the upstream emptying one-way valves, because of the increased pressure, so as to make the drink. The machine includes a control module able to command the increased pressures in the containers as a function of a desired composition for the drink.

Abstract: A process for producing a peptide antigen conjugate suitable for administration to a mammal is disclosed. The peptide antigen conjugate comprises a peptide antigen linked to a hydrophobic block. The process comprises reacting a hydrophobic block fragment with a peptide antigen fragment comprising the peptide antigen in a pharmaceutically acceptable organic solvent in a hydrophobic block fragment to peptide antigen fragment molar ratio of 1:1 or greater under conditions to directly or indirectly link the peptide antigen to the hydrophobic block and obtaining a product solution comprising the peptide antigen conjugate, unreacted hydrophobic block fragment and pharmaceutically acceptable organic solvent.

Abstract: An appliance for making a drink individually. The appliance includes a plurality of containers. Each container includes a vessel and a head screwed onto the vessel. A base defines a plurality of housings each receiving a container, and being provided with a housing outlet and a pressurizing inlet connected with a drain valve and a pressurizing valve of the container, respectively. A funnel is mounted under the housing outlets. Structure transfers by pressurization, into the funnel, ingredients contained in the containers housed in the housings. The vessel and the head of at least one container include polarizing surfaces of the vessel and of the head, respectively, configured to form, together, a container polarizing surface that can cooperate with a housing polarizing surface to ensure a predetermined positioning of the container with respect to the housing.

Abstract: An appliance for making a drink individually. The appliance includes a storage rack defining a plurality of housings configured to each receive a container containing an ingredient of the drink, and being provided with a housing outlet. The appliance includes a funnel including an outlet orifice. The appliance includes structure for transferring, into the funnel, through the housing outlets of the housings, ingredients contained in the containers. The appliance includes an emulsifier including an emulsifier shaft that is movable between positions in which it closes and leaves free the outlet orifice of the funnel.

Abstract: A remotely-controlled, movable, magnetic system and method for surveillance and attack prevention. The system includes a motive apparatus including a mounting body for mounting a series of magnets and wheels or rollers and suspending the apparatus from a magnetic ceiling T-bar grid or alternative metal track. The wheels or rollers make contact with the T-bars or track; provide some space between the magnets and T-bars or track; and allow for movement of the system along the T-bar grid or track. One or more of the wheels is drivingly connected to a drive motor. The system further includes a processor, an input/output interface, and a remote computing device or remote control for controlling the motive apparatus via a communications network. The motive apparatus further mounts components and tools remotely controlled by a user for observing, identifying a potential attacker, and hindering a potential attack.

Abstract: A remotely-controlled, movable, magnetic system and method for surveillance and attack prevention. The system includes a motive apparatus including a mounting body for mounting a series of magnets and wheels or rollers and suspending the apparatus from a magnetic ceiling T-bar grid or alternative metal track. The wheels or rollers make contact with the T-bars or track; provide some space between the magnets and T-bars or track; and allow for movement of the system along the T-bar grid or track. One or more of the wheels is drivingly connected to a drive motor. The system further includes a processor, an input/output interface, and a remote computing device or remote control for controlling the motive apparatus via a communications network. The motive apparatus further mounts components and tools remotely controlled by a user for observing, identifying a potential attacker, and hindering a potential attack.

Abstract: The present disclosure relates to novel peptide-based vaccines, methods of manufacturing the novel peptide-based vaccines and uses thereof for delivering peptide antigens to induce an immune response, and in particular a T cell response to a subject.

Abstract: A method for the non-destructive testing of the heating of a part made from polymer material, the method comprising the following steps: a) carrying out a measurement by infrared spectroscopy on a part to be tested and extracting therefrom at least one of absorbance values and transmittance values according to a spatial frequency; and b) from the measurement of at least one of absorbance and transmittance, determining the period of time during which said region of the part to be tested has been subjected to a given heating temperature and determining said heating temperature, using a reference database comprising at least one of absorbance measurements and transmittance measurements, the measurements established over a plurality of reference samples made from polymer material that have been subjected to a given temperature during a given period of time.

Abstract: Apparatus, for making an individual drink, with a pressure source, a store defining a plurality of housings, a plurality of removable containers each immobilized, in a service position, in a respective housing. Each container including a receptacle containing an ingredient, and an upstream emptying valve allowing the ingredient to leave towards the outside via an overpressure generated inside the receptacle by the pressure source. A chamber receives the ingredients extracted from the containers, via the upstream emptying valves, under the effect of the overpressure, so as to make the drink. A control module commands the overpressures in the containers as a function of a desired composition for the drink. Each housing includes a draining coupling via which the ingredient of the container immobilized in the housing can be extracted from the container. The draining coupling opening, in the downstream direction, directly into a funnel defined by the chamber.

Abstract: A method for the non-destructive testing of the heating of a part made from polymer material, the method comprising the following steps: a) carrying out a measurement by infrared spectroscopy on a part to be tested and extracting therefrom at least one of absorbance values and transmittance values according to a spatial frequency; and b) from the measurement of at least one of absorbance and transmittance, determining the period of time during which said region of the part to be tested has been subjected to a given heating temperature and determining said heating temperature, using a reference database comprising at least one of absorbance measurements and transmittance measurements, the measurements established over a plurality of reference samples made from polymer material that have been subjected to a given temperature during a given period of time.

Abstract: A method for executing a plurality of processing requests performed by a physical computing system that is programmed to execute the processing requests for clients includes, with the physical computing system, assigning an identification number to a new processing request; with the physical computing system, placing the new processing request into a process eligible group if the identification number of the new processing request meets a criterion; and with the physical computing system, placing the processing request into a queued group if the identification number of the processing request does not meet the criterion.

Abstract: A graphical user interface (GUI) presents a primary icon in a minimal visual area of a video display screen of a computer. Selecting the primary icon directs the computer to display a line of segments, where each segment associated with one or more software programs or electronic documents. The GUI allows a user to directly access items of visual and/or audio media by selecting one or more documents or software programs associated with a selected segment. The GUI optionally allows selected a line or segment for transmission from the computer to another computer, wherein copies one or more documents or software applications are transmitted to the second computer.

Abstract: A method, system, and medium are provided for dynamically generating pricing information for digital content. In exemplary aspects, the technology includes receiving a request for digital content from a mobile device. In addition, attributes associated with the mobile device and digital content are identified, and a purchase-prediction score associated with the mobile device and request for digital content is received. The purchase-prediction score is used to dynamically generate pricing information of the digital content. The purchase-prediction score is derived from values assigned to the attributes, the values quantifying a correlation between purchase trends and the attributes.

Abstract: A holster for a portable device is described. The holster includes a cleaning mechanism for cleaning a surface of a portable device while it is in the holster. The cleaning mechanism comprises a cleaning head movably coupled to a housing of the holster and positioned adjacent an interior surface of the holster; and an actuator coupled to the cleaning head and positioned on an exterior portion of the holster. Movement of the actuator moves the cleaning head, cleaning a portion of a surface of the portable device.