Patents by Inventor Geoffrey Otto
Geoffrey Otto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9200311Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.Type: GrantFiled: July 1, 2013Date of Patent: December 1, 2015Assignee: Pacific Biosciences of California, Inc.Inventors: Geoffrey Otto, Gene Shen, Xiangxu Kong, Robin Emig
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Patent number: 8936926Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.Type: GrantFiled: December 21, 2006Date of Patent: January 20, 2015Assignee: Pacific Biosciences of CaliforniaInventors: David Hanzel, Jonas Korlach, Paul Peluso, Geoffrey Otto, Thang Pham, David Rank, Stephen Turner
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Publication number: 20140038178Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.Type: ApplicationFiled: July 1, 2013Publication date: February 6, 2014Applicant: Pacific Biosciences of California, Inc.Inventors: Geoffrey OTTO, Gene SHEN, Xiangxu KONG, Robin EMIG
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Patent number: 8551704Abstract: The invention provides methods and compositions for the controlled termination of polymerase mediated primer extension reactions. The methods and compositions of the invention are broadly useful, and in a preferred aspect can be used in identifying sequence elements of template nucleic acids. Control of termination not only provides temporal control over termination, but, when used in conjunction with optically confined reaction regions, also spatially controls such termination.Type: GrantFiled: February 11, 2008Date of Patent: October 8, 2013Assignee: Pacific Biosciences of California, Inc.Inventors: Geoffrey Otto, John Lyle
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Patent number: 8501922Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.Type: GrantFiled: February 6, 2009Date of Patent: August 6, 2013Assignee: Pacific Biosciences of California, Inc.Inventors: Geoffrey Otto, Gene Shen, Xiangxu Kong, Robin Emig
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Patent number: 8415128Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: GrantFiled: July 26, 2011Date of Patent: April 9, 2013Assignee: Pacific Biosciences of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
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Patent number: 8323939Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.Type: GrantFiled: October 26, 2007Date of Patent: December 4, 2012Assignee: Pacific Biosciences of California, Inc.Inventors: David Hanzel, Jonas Korlach, Paul Peluso, Geoffrey Otto, Thang Pham, David Rank, Stephen Turner
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Publication number: 20120028250Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: ApplicationFiled: July 26, 2011Publication date: February 2, 2012Applicant: Pacific Biosciences of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
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Patent number: 8071346Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: GrantFiled: October 31, 2007Date of Patent: December 6, 2011Assignee: Pacific Bioscience of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
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Patent number: 7998717Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: GrantFiled: December 2, 2005Date of Patent: August 16, 2011Assignee: Pacific Biosciences of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
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Patent number: 7993895Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: GrantFiled: December 1, 2006Date of Patent: August 9, 2011Assignee: Pacific Biosciences of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
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Patent number: 7907800Abstract: Methods for monitoring reactions are provided, including methods involving monitoring reactions in zero mode waveguide substrates. The zero mode waveguide substrates have zero mode waveguides wherein the core extends through the cladding layer at least partially into the transparent substrate.Type: GrantFiled: December 22, 2008Date of Patent: March 15, 2011Assignee: Pacific Biosciences of California, Inc.Inventors: Mathieu Foquet, Paul Peluso, Stephen Turner, Daniel Bernardo Roitman, Geoffrey Otto
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Publication number: 20100261247Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.Type: ApplicationFiled: December 21, 2006Publication date: October 14, 2010Applicant: Pacific Biosciences of California, Inc.Inventors: David Hanzel, Jonas Korlach, Paul Peluso, Geoffrey Otto, Thang Pham, David Rank, Stephen Turner
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Publication number: 20090325166Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.Type: ApplicationFiled: December 22, 2008Publication date: December 31, 2009Applicant: Pacific Biosciences of California, Inc.Inventors: Mathieu Foquet, Paul Peluso, Stephen Turner, Daniel Bernardo Roitman, Geoffrey Otto
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Publication number: 20090325260Abstract: The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates.Type: ApplicationFiled: February 6, 2009Publication date: December 31, 2009Applicant: Pacific Biosciences of California, Inc.Inventors: Geoffrey Otto, Gene Shen, Xiangxu Kong, Robin Emig
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Patent number: 7486865Abstract: Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.Type: GrantFiled: June 11, 2007Date of Patent: February 3, 2009Assignee: Pacific Biosciences of California, Inc.Inventors: Mathieu Foquet, Paul Peluso, Stephen Turner, Daniel Bernardo Roitman, Geoffrey Otto
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Publication number: 20080199932Abstract: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.Type: ApplicationFiled: October 26, 2007Publication date: August 21, 2008Applicant: Pacific Biosciences of California, Inc.Inventors: David Hanzel, Jonas Korlach, Paul Peluso, Geoffrey Otto, Thang Pham, David Rank, Stephen Turner
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Publication number: 20080199874Abstract: The invention provides methods and compositions for the controlled termination of polymerase mediated primer extension reactions. The methods and compositions of the invention are broadly useful, and in a preferred aspect can be used in identifying sequence elements of template nucleic acids. Control of termination not only provides temporal control over termination, but, when used in conjunction with optically confined reaction regions, also spatially controls such termination.Type: ApplicationFiled: February 11, 2008Publication date: August 21, 2008Applicant: Pacific Biosciences of California, Inc.Inventors: Geoffrey Otto, John Lyle
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Publication number: 20080176241Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: ApplicationFiled: October 31, 2007Publication date: July 24, 2008Applicant: Pacific Biosciences of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
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Publication number: 20080176316Abstract: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.Type: ApplicationFiled: October 31, 2007Publication date: July 24, 2008Applicant: Pacific Biosciences of California, Inc.Inventors: John Eid, Devon Murphy, Geoffrey Otto, Stephen Turner
