Patents by Inventor Geoffrey Phillip Dobson
Geoffrey Phillip Dobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10786525Abstract: The invention relates to a composition and method for increasing blood pressure, including a low pain or analgesic state or hypotensive anaesthesia in a subject that has suffered a life threatening hypotension or shock or reducing hypofusion in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; and (ii) an antiarrhythmic agent or a local anaesthetic.Type: GrantFiled: January 19, 2016Date of Patent: September 29, 2020Assignee: HIBERNATION THERAPEUTICS A KF LLCInventor: Geoffrey Phillip Dobson
-
Patent number: 10251905Abstract: The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.Type: GrantFiled: May 21, 2013Date of Patent: April 9, 2019Assignee: HIBERNATION THERAPEUTICS, A KF LLCInventor: Geoffrey Phillip Dobson
-
Publication number: 20160374331Abstract: The present invention relates to a method for reducing electrical disturbance of a cell's resting membrane potential comprising administering an effective amount of a composition comprising an effective amount of a local anaesthetic and of one or more of a potassium channel opener, an adenosine receptor agonist, an anti-adrenergic, a calcium antagonist, an opioid, an NO donor and a sodium hydrogen exchange inhibitor.Type: ApplicationFiled: July 6, 2016Publication date: December 29, 2016Applicant: Hibernation Therapeutics, A KF LLCInventor: Geoffrey Phillip Dobson
-
Publication number: 20160271161Abstract: The invention relates to a composition and method for increasing blood pressure, including a low pain or analgesic state or hypotensive anaesthesia in a subject that has suffered a life threatening hypotension or shock or reducing hypofusion in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; and (ii) an antiarrhythmic agent or a local anaesthetic.Type: ApplicationFiled: January 19, 2016Publication date: September 22, 2016Inventor: Geoffrey Phillip Dobson
-
Publication number: 20160263141Abstract: The present invention relates to a method for arresting, protecting and/or preserving an organ which includes administering effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) local anaesthetic to a subject in need thereof. The present invention also relates to a method for arresting, protecting and/or preserving an organ which comprises adding a composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic to the organ. The present invention further provides a pharmaceutical or veterinary composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic.Type: ApplicationFiled: March 18, 2016Publication date: September 15, 2016Applicant: HIBERNATION THERAPEUTICS, A KF, LLCInventor: Geoffrey Phillip Dobson
-
Publication number: 20160166598Abstract: The invention relates to a composition or method for treating at least one of infection, sepsis and injury or inducing a hypotensive state or a low pain or analgesic state in a subject susceptible to or suffering from at least one of infection, sepsis and injury. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; and (ii) an antiarrhythmic agent or a local anaesthetic.Type: ApplicationFiled: July 17, 2014Publication date: June 16, 2016Inventor: Geoffrey Phillip Dobson
-
Publication number: 20160158280Abstract: The invention relates to compositions and methods for Inducing organ arrest, maintaining arrest and reanimating in a subject that has suffered a life threatening disease or injury; preparing, harvesting, storing organs, tissues and cells; reducing the harmful effects of at least one of anaesthesia, surgery, clinical intervention, and cardiopulmonary bypass on injuring the tissues, organs and cells of a subject; or reducing the harmful effects of surgery or clinical intervention on injuring the organs and brain in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; (ii) an antiarrhythmic agent or a local anaesthetic; and (iii) citrate.Type: ApplicationFiled: July 17, 2014Publication date: June 9, 2016Inventor: Geoffrey Phillip Dobson
-
Patent number: 9320753Abstract: The present invention relates to a method for arresting, protecting and/or preserving an organ which includes administering effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) local anaesthetic to a subject in need thereof. The present invention also relates to a method for arresting, protecting and/or preserving an organ which comprises adding a composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic to the organ. The present invention further provides a pharmaceutical or veterinary composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic.Type: GrantFiled: March 5, 2013Date of Patent: April 26, 2016Assignee: Hibernation Therapeutics, A KF LLCInventor: Geoffrey Phillip Dobson
-
Publication number: 20160051572Abstract: The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic.Type: ApplicationFiled: August 13, 2015Publication date: February 25, 2016Applicant: Hibernation Therapeutics, A KF LLCInventor: Geoffrey Phillip Dobson
-
Patent number: 9125929Abstract: The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic.Type: GrantFiled: January 24, 2013Date of Patent: September 8, 2015Assignee: Hibernation Therapeutics, A KF LLCInventor: Geoffrey Phillip Dobson
-
Publication number: 20150164065Abstract: The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia and compound for reducing the uptake of water by a cell in the tissue. The present invention also relates to the use of the composition according to the invention for controlling viability of a tissue.Type: ApplicationFiled: February 27, 2015Publication date: June 18, 2015Inventor: GEOFFREY Phillip DOBSON
-
Publication number: 20150038447Abstract: This application describes compositions, methods of treatment, and methods of manufacturing a medicament for reducing injury or damage to cells, tissues or organs during ischemia, reperfusion, or following ischemia or trauma. The methods for reducing damage to a cell, tissue or organ comprise administering an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; and (ii) an antiarrhythmic agent. The methods may further include postconditioning the cell, tissue or organ.Type: ApplicationFiled: October 3, 2014Publication date: February 5, 2015Inventor: Geoffrey Phillip Dobson
-
Patent number: 8946189Abstract: The present invention relates to a method of reducing injury to cells, a tissue or organ to be explanted from a body and upon implantation into a body by administering a composition to the cell, tissue or organ, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent. The invention also provides a composition for reducing injury to vasculature ex vivo including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) an antiarrhythmic agent.Type: GrantFiled: November 13, 2012Date of Patent: February 3, 2015Assignee: Hibernation Therapeutics, A KF LLCInventor: Geoffrey Phillip Dobson
-
Publication number: 20140011745Abstract: The present invention relates to a method for reducing electrical disturbance of a cell's resting membrane potential comprising administering an effective amount of a composition comprising an effective amount of a local anaesthetic and of one or more of a potassium channel opener, an adenosine receptor agonist, an anti-adrenergic, a calcium antagonist, an opioid, an NO donor and a sodium hydrogen exchange inhibitor.Type: ApplicationFiled: July 5, 2013Publication date: January 9, 2014Applicant: Hibernation Therapeutics LimitedInventor: Geoffrey Phillip Dobson
-
Publication number: 20140005137Abstract: The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.Type: ApplicationFiled: May 21, 2013Publication date: January 2, 2014Applicant: HIBERNATION THERAPEUTICS LIMITEDInventor: Geoffrey Phillip Dobson
-
Publication number: 20130302779Abstract: This application describes compositions, methods of treatment, and methods of manufacturing a medicament for reducing injury or damage to cells, tissues or organs during ischemia, reperfusion, or following ischemia or trauma. The methods for reducing damage to a cell, tissue or organ comprise administering an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; and (ii) an antiarrhythmic agent. The methods may further include postconditioning the cell, tissue or organ.Type: ApplicationFiled: July 17, 2013Publication date: November 14, 2013Applicant: Hibernation Therapeutics LimitedInventor: Geoffrey Phillip Dobson
-
Publication number: 20130190264Abstract: The invention provides a method of reducing injury to cells, tissues or organs of a body following trauma by administering a composition to the body following trauma, including: (i) a potassium channel opener or agonist and/or an adenosine receptor agonist; and (ii) a local anaesthetic. Also provided is a composition for reducing injury to cells, tissues or organs of a body following trauma including: (i) and (ii). The composition may be hypertonic.Type: ApplicationFiled: January 24, 2013Publication date: July 25, 2013Applicant: Hibernation Therapeutics LimitedInventor: Geoffrey Phillip Dobson
-
Publication number: 20120190003Abstract: The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia and a compound for reducing the uptake of water by a cell in the tissue. The present invention also relates to the use of the composition according to the invention for controlling viability of a tissue.Type: ApplicationFiled: April 2, 2012Publication date: July 26, 2012Applicant: Global Cardiac Solutions Pty Ltd.Inventor: Geoffrey Phillip Dobson
-
Publication number: 20120094268Abstract: The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or an adenosine receptor agonist (eg. adenosine) together with a local anaesthetic (eg. lignocaine) when perfusing the organ.Type: ApplicationFiled: December 27, 2011Publication date: April 19, 2012Applicant: Hibernation Therapeutics LimitedInventor: Geoffrey Phillip Dobson
-
Publication number: 20100298254Abstract: The present invention relates to a method for arresting, protecting and/or preserving an organ which includes administering effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) local anaesthetic to a subject in need thereof. The present invention also relates to a method for arresting, protecting and/or preserving an organ which comprises adding a composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic to the organ. The present invention further provides a pharmaceutical or veterinary composition which includes effective amounts of (i) a potassium channel opener or agonist and/or an adenosine receptor agonist and (ii) a local anaesthetic.Type: ApplicationFiled: May 27, 2010Publication date: November 25, 2010Applicant: Hibernation Therapeutics LimitedInventor: Geoffrey Phillip Dobson