Patents by Inventor Geoffrey S. Ginsburg

Geoffrey S. Ginsburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE EXPRESSION SIGNATURES USEFUL TO PREDICT OR DIAGNOSE SEPSIS AND METHODS OF USING THE SAME
    Publication number: 20220251647
    Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.
    Type: Application
    Filed: February 18, 2022
    Publication date: August 11, 2022
    Inventors: Ephraim L. Tsalik, Geoffrey S. Ginsburg, Christopher W. Woods, Ricardo Henao Giraldo, Rachel A. Myers
  • Gene expression signatures useful to predict or diagnose sepsis and methods of using the same
    Patent number: 11286525
    Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: March 29, 2022
    Assignees: Duke University, United States Government as Represented by the Department of Veterans Affairs
    Inventors: Ephraim L. Tsalik, Geoffrey S. Ginsburg, Christopher W. Woods, Ricardo Henao Giraldo, Rachel A. Myers
  • Diagnostic markers for platelet function and methods of use
    Patent number: 11008619
    Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to antiplatelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: May 18, 2021
    Assignee: Duke University
    Inventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
  • Biomarkers for the molecular classification of bacterial infection
    Patent number: 10689701
    Abstract: Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
    Type: Grant
    Filed: March 15, 2014
    Date of Patent: June 23, 2020
    Assignee: Duke University
    Inventors: Ephraim Tsalik, Vance Fowler, Christopher W. Woods, Joseph E. Lucas, Geoffrey S. Ginsburg, Sun Hee Ahn
  • GENE EXPRESSION SIGNATURES USEFUL TO PREDICT OR DIAGNOSE SEPSIS AND METHODS OF USING THE SAME
    Publication number: 20200157623
    Abstract: The present disclosure provides methods for determining whether a subject has sepsis, or is at risk of developing sepsis, and methods of treating the subject based on the determination. Also provided are methods for determining an increased risk of mortality in a subject with sepsis or suspected of having sepsis, and methods of treating the subject based on the determination. Systems useful for the same are also provided.
    Type: Application
    Filed: January 16, 2018
    Publication date: May 21, 2020
    Inventors: Ephraim L. TSALIK, Geoffrey S. GINSBURG, Christopher W. WOODS, Ricardo Henao GIRALDO, Rachel A. MYERS
  • DIAGNOSTIC MARKERS FOR PLATELET FUNCTION AND METHODS OF USE
    Publication number: 20200063203
    Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to antiplatelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.
    Type: Application
    Filed: May 16, 2019
    Publication date: February 27, 2020
    Inventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
  • NASOPHARYNGEAL PROTEIN BIOMARKERS OF ACUTE RESPIRATORY VIRUS INFECTION AND METHODS OF USING SAME
    Publication number: 20190376969
    Abstract: The present disclosure provides methods for determining the presence or absence of and/or the etiology of an acute respiratory viral infection in a subject, as well as methods of treating the subject based on the determination, by measuring on a platform the expression levels of a pre-defined set of gene products.
    Type: Application
    Filed: February 2, 2018
    Publication date: December 12, 2019
    Inventors: Thomas W. Burke, Ricardo Henao Giraldo, Erik Soderblom, Joseph Lucas, Christopher W. Woods, Geoffrey S. Ginsburg
  • Diagnostic markers for platelet function and methods of use
    Patent number: 10329618
    Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: June 25, 2019
    Assignee: Duke University
    Inventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
  • Predicting coronary artery disease and risk of cardiovascular events
    Patent number: 10317414
    Abstract: Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: June 11, 2019
    Assignee: Duke University
    Inventors: Svati H. Shah, Christopher B. Newgard, William E. Kraus, Elizabeth R. Hauser, Geoffrey S. Ginsburg, L. Kristin Newby
  • METHODS TO DIAGNOSE AND TREAT ACUTE RESPIRATORY INFECTIONS
    Publication number: 20180245154
    Abstract: The present disclosure provides methods for determining the etiology of an acute respiratory infection in a subject and methods of treating the subject based on the determination, as well as systems useful for performing the determination using a biological sample from the subject.
    Type: Application
    Filed: June 30, 2016
    Publication date: August 30, 2018
    Inventors: Ephraim L. Tsalik, Ricardo Henao Giraldo, Thomas W. Burke, Geoffrey S. Ginsburg, Christopher W. Woods, Micah T. McClain
  • Biomarkers for the molecular classification of bacterial infection
    Patent number: 9850539
    Abstract: Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: December 26, 2017
    Assignee: Duke University
    Inventors: Ephraim Tsalik, Vance Fowler, Christopher W. Woods, Joseph E. Lucas, Geoffrey S. Ginsburg, Sun Hee Ahn
  • MOLECULAR PREDICTORS OF FUNGAL INFECTION
    Publication number: 20160194715
    Abstract: Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of identifying fungal infection by proteomic assay involves measuring the protein levels of proteins listed in Table 2A in a peripheral blood cell sample and comparing the determined protein levels to standard protein levels. In another aspect, subjects identified as being infected with fungal infection are treated with anti-fungals.
    Type: Application
    Filed: December 28, 2015
    Publication date: July 7, 2016
    Inventors: Aimee K. Zaas, Geoffrey S. Ginsburg, Joseph Lucas, Hamza Aziz, John R. Perfect
  • PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS
    Publication number: 20160195543
    Abstract: Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.
    Type: Application
    Filed: March 10, 2016
    Publication date: July 7, 2016
    Inventors: Svati H. Shah, Christopher B. Newgard, William E. Kraus, Elizabeth R. Hauser, Geoffrey S. Ginsburg, L. Kristin Newby
  • BIOMARKERS FOR THE MOLECULAR CLASSIFICATION OF BACTERIAL INFECTION
    Publication number: 20160097099
    Abstract: Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
    Type: Application
    Filed: October 12, 2015
    Publication date: April 7, 2016
    Inventors: Ephraim Tsalik, Vance Fowler, Christopher W. Woods, Joseph E. Lucas, Geoffrey S. Ginsburg, Sun Hee Ahn
  • DIAGNOSTIC MARKERS FOR PLATELET FUNCTION AND METHODS OF USE
    Publication number: 20150322514
    Abstract: Disclosed herein are biomarkers of platelet function and methods for assessing platelet function in response to anti-platelet therapy and for determining a prognosis, diagnosis, or risk identification in a patient by detecting at least one biomarker of platelet function in the patient as well as determining amounts thereof. The biomarkers may be used to identify a patient as a candidate for treatment with an antiplatelet agent and to monitor and adjust antiplatelet therapy in a patient.
    Type: Application
    Filed: September 6, 2013
    Publication date: November 12, 2015
    Inventors: Geoffrey S. Ginsburg, Joseph E. Lucas, Thomas L. Ortel, Richard C. Becker, Deepak Voora, Jen-Tsan Chi
  • BIOMARKERS FOR THE MOLECULAR CLASSIFICATION OF BACTERIAL INFECTION
    Publication number: 20140323391
    Abstract: Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
    Type: Application
    Filed: March 15, 2014
    Publication date: October 30, 2014
    Applicant: Duke University
    Inventors: Ephraim Tsalik, Vance Fowler, Christopher W. Woods, Joseph E. Lucas, Geoffrey S. Ginsburg, Sun Hee Ahn
  • Methods of identifying infectious disease and assays for identifying infectious disease
    Patent number: 8821876
    Abstract: Methods of identifying infectious disease infection prior to presentation of symptoms, assays for identifying genomic markers of infectious disease, and methods for diagnosing the underlying etiology of infectious disease.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: September 2, 2014
    Assignee: Duke University
    Inventors: Geoffrey S. Ginsburg, Joseph Lucas, Christopher W. Woods, Lawrence Carin, Aimee K. Zaas, Alfred Hero
  • METHODS OF IDENTIFYING INFECTIOUS DISEASE AND ASSAYS FOR IDENTIFYING INFECTIOUS DISEASE
    Publication number: 20120114661
    Abstract: Methods of identifying infectious disease infection prior to presentation of symptoms, assays for identifying genomic markers of infectious disease, and methods for diagnosing the underlying etiology of infectious disease.
    Type: Application
    Filed: May 26, 2010
    Publication date: May 10, 2012
    Inventors: Geoffrey S. Ginsburg, Joseph Lucas, Christopher W. Woods, Lawrence Carin, Aimee K. Zaas, Alfred Hero
  • MOLECULAR PREDICTORS OF FUNGAL INFECTION
    Publication number: 20120077767
    Abstract: Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of identifying fungal infection by proteomic assay involves measuring the protein levels of proteins listed in Table 2A in a peripheral blood cell sample and comparing the determined protein levels to standard protein levels. In another aspect, subjects identified as being infected with fungal infection are treated with anti-fungals.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 29, 2012
    Inventors: Aimee K. Zaas, Geoffrey S. Ginsburg, Joseph Lucas, Hamza Aziz, John R. Perfect
  • PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS
    Publication number: 20110318726
    Abstract: Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarnitines, amino acids, ketones, free fatty acids or hydroxybutyrate. The cardiovascular disease may be risk of a cardiovascular event, presence of coronary artery disease or risk of development of coronary artery disease.
    Type: Application
    Filed: March 10, 2010
    Publication date: December 29, 2011
    Inventors: Svati H. Shah, Christopher B. Newgard, William E. Kraus, Elizabeth R. Hauser, Geoffrey S. Ginsburg, L. Kristin Newby