Abstract: A first aspect of the invention relates to a method of treating a proliferative disorder in a subject, said method comprising administering to the subject a therapeutically effective amount of (i) sapacitabine, or a metabolite thereof; and (ii) seliciclib; in accordance with a dosing regimen comprising at least one first treatment cycle and at least one second treatment cycle, wherein said first treatment cycle comprises: (a) administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 3 to 5 consecutive days for 2 weeks, starting on day d, where d is the first day of treatment with sapacitabine, or the metabolite thereof, in said first treatment cycle; and (b) optionally administering a therapeutically effective amount of seliciclib for 3 to 5 consecutive days for 2 weeks, starting on day (d?1) relative to the administration of sapacitabine or the metabolite thereof, in said first treatment cycle; followed by a rest period of at least 2 weeks, or until treatment-related toxi

Abstract: A system and method are provided for integrating voice communication systems with voice recognition devices or units and myriad other data sources to provide a harmonization between intended aircraft operations and actual aircraft operations, including logical components to provide a mechanism to flag certain alert communications that signal the initiation of particular response scenarios based on detected terms and track initiation of pre-planned processes to address specific events that are signaled through the use of the detected terms. Information from myriad data sources is collected and integrated to provide an indication of intended operations for an aircraft. A data comparison device compares the indicated real-time intended operations of the aircraft with actual monitored operations of the aircraft to discern unacceptable deviations.

Abstract: A computer system receives a voice command and applies one or more contextual filters produce avionics commands based on the voice command. Elements of the voice command are displayed for acceptance by a pilot before being implemented by an avionics system. Individual elements are reevaluated as necessary. Contextual filters include flight paths, flight phase, aircraft location, current weather conditions or information associated with a particular airport.

Abstract: Voice-operable avionic systems and methods supporting utilization of speech recognition to facilitate control of avionic systems are disclosed. Utilizing speech recognition to control avionic systems may help reduce the head-down time of the flight crew. Safety features may also be implemented to ensure safety-critical commands are carried out as intended when commands are received through speech recognition. In addition, voice-operable avionic systems configured in accordance with embodiments of the inventive concepts disclosed herein may be implemented in manners that can help reduce the complexity and cost associated with obtaining certifications from aviation authorities.

Abstract: A distributed system for flight and route management (FARM) of one or more aircraft of the system may include onboard processing devices for combining sensor data local to an aircraft with cloud-based data received through the system from other aircraft or from ground-based processing devices, thereby generating situation models of each aircraft relative to its flight path and in the context of current and predictive conditions (weather, traffic, terrain, threats, etc.). The FARM system may evaluate situation models against prioritized constraint sets of business rules or policies associated with each aircraft's flight plan to determine, crosscheck, and implement possible modifications to the flight plan. Localized aircraft data and flight plan modifications may be propagated through the system via a variety of communications networks to provide synchronized, holistic airspace data portraits to aircraft and ground control alike.

Abstract: A method. The method includes receiving user input data from a user interface system. The user input data includes user gesture data, wherein the user gesture data is associated with one or more detected user gestures. The method also includes manipulating one or more graphical flight path elements based at least upon received user gesture data. The method further includes performing at least one flight path modification operation based at least upon one or more factors and the received user gesture data. The method additionally includes outputting updated graphical data to the user interface system, wherein the updated graphical data includes updated graphical flight path element data and updated graphical flight path data.

Abstract: Methods and systems for identifying and displaying potentially hazardous segments on a planned route of a vehicle are disclosed. A method may include: predicting a movement of a condition of concern; analyzing the movement of the condition of concern and a movement of a vehicle traveling along a planned route to generate a projection of the condition of concern onto the planned route, wherein the projection indicates conditions the vehicle is predicted to encounter at a plurality of positions along the planned route; determining whether a portion of the planned route is potentially hazardous based on the projection of the condition of concern; and visually identifying the portion of the planned route that is potentially hazardous to a user. The method may also be utilized to facilitate a reroute process.

Abstract: A system includes an auto-flight system and a touchscreen flight mode control panel. The auto-flight system is configured to control a plurality of primary flight modes. The touchscreen flight mode control panel is communicatively coupled to the auto-flight system. The touchscreen flight mode control panel is configured to receive primary flight mode data from the auto-flight system. The touchscreen flight mode control panel is also configured to graphically present each primary flight mode of the plurality of primary flight modes to a user. The touchscreen flight mode control panel is further configured to detect touch gestures and direct executions of the user. The touchscreen flight mode control panel is additionally configured to output touch gesture data and direct execution data to the auto-flight system.

Abstract: A system and method for an interactive avionics display system integrates a large-format primary avionics display, a secondary avionics display capable of mirroring the display of electronic flight bag mobile devices, a format selector panel, and a keyboard panel. Background displays and foreground multifunction windows generated by the display system house applications and display relevant avionics data. The multifunction windows can be resized or repositioned on the display surface using finger contacts and gestures. Format selector panels include control selectors corresponding to the multifunction windows, the control selectors responsive to finger contact with the format selector panels or the corresponding multifunction windows. Keyboard panels provide touch-sensitive radio and communications controls as well as an alphanumeric keyboard responsive to finger contact with text fields generated by the display.

Abstract: Present novel and non-trivial methods for electronically recording a taxi clearance on a display unit are disclosed. In one method, an interactive surface map is displayed from which selections of an assigned takeoff runway and taxiway(s) stated in a taxi clearance may be made electronically through advanced gesturing techniques. These selections highlight the surfaces stated in the taxi clearance. The selections may be made through a series of touch screen taps and/or by the grabbing, dragging, and releasing of a “rubber band” which snaps into place over the selected surface. In another method, an auto-route generating algorithm may be employed to create a preliminary taxi clearance after a presumed runway for takeoff has been selected by the pilot. Then, as the taxi clearance is being received, changes may be made through the pilot's interaction with the graphical user interfaces commensurate with the actual taxi clearance.

Abstract: The present disclosure is directed to a method for managing a user interface. The method may include the step of detecting a gaze of a user within a display. The method also includes the step of correlating the gaze of the user to an item displayed on the display. A further step of the method entails receiving an input from the user related to the item.

Abstract: Methods and systems for identifying and displaying potentially hazardous segments on a planned route of a vehicle are disclosed. A method may include: predicting a movement of a condition of concern; analyzing the movement of the condition of concern and a movement of a vehicle traveling along a planned route to generate a projection of the condition of concern onto the planned route, wherein the projection indicates conditions the vehicle is predicted to encounter at a plurality of positions along the planned route; determining whether a portion of the planned route is potentially hazardous based on the projection of the condition of concern; and visually identifying the portion of the planned route that is potentially hazardous to a user. The method may also be utilized to facilitate a reroute process.

Abstract: Present novel and non-trivial methods for electronically recording a taxi clearance on a display unit are disclosed. In one method, an interactive surface map is displayed from which selections of an assigned takeoff runway and taxiway(s) stated in a taxi clearance may be made electronically through advanced gesturing techniques. These selections highlight the surfaces stated in the taxi clearance. The selections may be made through a series of touch screen taps and/or by the grabbing, dragging, and releasing of a “rubber band” which snaps into place over the selected surface. In another method, an auto-route generating algorithm may be employed to create a preliminary taxi clearance after a presumed runway for takeoff has been selected by the pilot. Then, as the taxi clearance is being received, changes may be made through the pilot's interaction with the graphical user interfaces commensurate with the actual taxi clearance.

Abstract: A system includes an auto-flight system and a touchscreen flight mode control panel. The auto-flight system is configured to control a plurality of primary flight modes. The touchscreen flight mode control panel is communicatively coupled to the auto-flight system. The touchscreen flight mode control panel is configured to receive primary flight mode data from the auto-flight system. The touchscreen flight mode control panel is also configured to graphically present each primary flight mode of the plurality of primary flight modes to a user. The touchscreen flight mode control panel is further configured to detect touch gestures and direct executions of the user. The touchscreen flight mode control panel is additionally configured to output touch gesture data and direct execution data to the auto-flight system.

Abstract: A first aspect of the invention relates to a method of treating a proliferative disorder in a subject, said method comprising administering to the subject a therapeutically effective amount of (i) sapacitabine, or a metabolite thereof; and (ii) seliciclib; in accordance with a dosing regimen comprising at least one first treatment cycle and at least one second treatment cycle, wherein said i first treatment cycle comprises: (a) administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, for 3 to 5 consecutive days for 2 weeks, starting on day d, where d is the first day of treatment with sapacitabine, or the metabolite thereof, in said first treatment cycle; and (b) optionally administering a therapeutically effective amount of seliciclib for 3 to 5 consecutive days for 2 weeks, starting on day (d?1) relative to the administration of sapacitabine or the metabolite thereof, in said first treatment cycle; followed by a rest period of at least 2 weeks, or until treatment-related to

Abstract: A schematic display for presenting vertical navigation (VNAV) data is disclosed. A planned route such as a flight plan is divided into a series of VNAV legs, and only a VNAV schematic that corresponds to the active VNAV leg is displayed. The VNAV schematic in accordance with the present disclosure is a profile-view schematic for the active VNAV leg, providing a visual representation indicating the locations of the upcoming Top of Climb (TOC) or Top of Descent (TOD). Additional VNAV data may also be presented to provide content context. Since the schematic display in accordance with the present disclosure only displays VNAV data relevant to the active VNAV leg at a given time, the complexities associated with displaying the VNAV schematic is reduced, making the VNAV data easy to read and understand.

Abstract: A system for disabling touch panel input capabilities may include, but is not limited to: a touch panel device including a touch panel controller; a touch panel input processing device; an isolation switching means coupling at least one of a touch panel device and the touch panel controller to the touch panel input processing device; and an electromagnetic interference (EMI) detection system configured to provide control signals to the isolation switching means.

Abstract: A present novel and non-trivial system, module, and method for presenting runway advisory information are disclosed. A runway reference may be established using data received from a source of navigation reference data, where such data could represent runway information, runway awareness zone information, landing awareness zone information, and/or runway threshold line information. Navigation data representative of at least aircraft location and input factor data may be received from a source. Phase of flight may be determined using input factor data, and a runway advisory data set may be generated as a function of phase of flight and the positional relationship between aircraft location and the runway reference. Runway advisory data set may be representative of advisory information comprised of visual runway advisory information, aural runway advisory information, tactile advisory information, or a combination thereof.