Abstract: The present invention concerns the use of an alpha-glucosidase glycoprotein processing inhibitor for the treatment or prevention of human coronavirus infections, such as SARS-CoV-2 or SARS-CoV-2 variant infections. Aspects of the invention include methods for treating or preventing coronavirus infection, or a symptom thereof, by administering an alpha-glucosidase glycoprotein processing inhibitor, such as castanospermine, or a pharmaceutically acceptable salt, derivative, or prodrug thereof, to a human subject; methods for inhibiting human coronavirus infection in a human cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing human coronavirus infection.

Abstract: The present invention concerns the use of an alpha-glucosidase glycoprotein processing inhibitor for the treatment or prevention of human coronavirus infections, such as SARS-CoV-2 or SARS-CoV-2 variant infections. Aspects of the invention include methods for treating or preventing coronavirus infection, or a symptom thereof, by administering an alpha-glucosidase glycoprotein processing inhibitor, such as castanospermine, or a pharmaceutically acceptable salt, derivative, or prodrug thereof, to a human subject; methods for inhibiting human coronavirus infection in a human cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing human coronavirus infection.

Abstract: The present invention concerns the use of an alpha-glucosidase glycoprotein processing inhibitor for the treatment or prevention of human coronavirus infections, such as SARS-CoV-2 or SARS-CoV-2 variant infections. Aspects of the invention include methods for treating or preventing coronavirus infection, or a symptom thereof, by administering an alpha-glucosidase glycoprotein processing inhibitor, such as castanospermine, or a pharmaceutically acceptable salt, derivative, or prodrug thereof, to a human subject; methods for inhibiting human coronavirus infection in a human cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing human coronavirus infection.

Abstract: A detector probe, for detecting ionizing radiation and which is suitable for use in a nucleonic instrument usable in locations having a high ambient temperature, includes an array of radiation detectors mounted on a support and a heat pipe for cooling the detector probe. The nucleonic instrument incorporating such a detector probe is also described.

Abstract: A detector probe for detecting ionizing radiation includes at least one detector (14) mounted on a support (12), and an electrically operated source of heat (18) arranged on the support in proximity to the detector so that the temperature of the detector may be changed by operation of the heat source. The detector probe may be used in the manufacture of a level gauge or density profiler.

Abstract: A nucleonic density profiler includes a detector probe, for detecting ionizing radiation, includes an array of sources of ionizing radiation, an array of radiation detectors and a circuit board including at least two circuit board portions. A power source and electronic apparatus includes a control unit and a signal and data processor for calculating a density profile of the material phases using signals generated by the detectors in response to radiation received from the radiation sources.

Abstract: A method and system for generating a vector graphic from a color/object coded hand-drawn diagram are provided. A digital image of the diagram is generated and the key to the color/object code used to code the diagram is obtained. The digital image is then filtered to create a color-filtered image for each color in the key. Each filtered image is analyzed to determine the object type of objects in the filtered image according to the key, and then data extracted from the analysis of the filtered images is combined into a vector graphic diagram. The use of coded color in the diagram enables the image to be filtered based on color, which in turn aids the automated recognition of components in the diagram and significantly reduces the complexity of identifying each type of shape.

Abstract: A radiation detector module includes a radiation detector, power source and wireless communication elements all housed within a flame-proof enclosure. The enclosure has a portion through which wireless transmissions can pass. The radiation detector module may be suitable for use in a hazardous area containing a potentially explosive gas mixture.

Abstract: A nucleonic density profiler includes a detector probe, for detecting ionizing radiation, includes an array of radiation detectors and a circuit board including at least two circuit board portions.

Abstract: A detector probe, for detecting ionizing radiation and which is suitable for use in a nucleonic instrument usable in locations having a high ambient temperature, includes an array of radiation detectors mounted on a support and a heat pipe for cooling the detector probe. The nucleonic instrument incorporating such a detector probe is also described.

Abstract: The invention comprises an apparatus comprising a water-proof housing assembly comprising a housing (20) and a display panel (10, 32), and incorporating an enclosure (30) containing electrical apparatus, wherein said display panel is formed from a clear material (16) encapsulating a visual display (12) and/or a light-source (34) and said apparatus is capable of operating in water at a pressure of at least 300 bar without ingress of water into the enclosure. The apparatus may be used as an instrument or a lighting unit in sub-sea environments. The invention comprises further a light-source attachment for a powered apparatus comprising a light source embedded within a block of clear material (16) and means for mounting said block on the powered apparatus such that a connector connects the light source to a power source within the powered apparatus.

Abstract: A radiation detector module includes a radiation detector, power source and wireless communication elements all housed within a flame-proof enclosure. The enclosure has a portion through which wireless transmissions can pass. The radiation detector module may be suitable for use in a hazardous area containing a potentially explosive gas mixture.

Abstract: A detector probe for detecting ionising radiation includes at least one detector (14) mounted on a support (12), and an electrically operated source of heat (18) arranged on the support in proximity to the detector so that the temperature of the detector may be changed by operation of the heat source. The detector probe may be used in the manufacture of a level gauge or density profiler.

Abstract: Disclosed are various embodiments for a call control application bridges communication devices with a media call. In one embodiment, the call control application receives a request to place a media call from a source device to a destination device. The call control application determines if at least one of the source device and the destination device is associated with a telephone number registered in a relay registry. In response to a determination that the telephone number is registered in the registry, the call control application directs an intermediary agent to place a first media call to the source device and a second media call to the destination device. The call control application then bridges the first media call and the second media call via the intermediary agent.

Abstract: The invention comprises an apparatus comprising a water-proof housing assembly comprising a housing (20) and a display panel (10, 32), and incorporating an enclosure (30) containing electrical apparatus, wherein said display panel is formed from a clear material (16) encapsulating a visual display (12) and/or a light-source (34) and said apparatus is capable of operating in water at a pressure of at least 300 bar without ingress of water into the enclosure. The apparatus may be used as an instrument or a lighting unit in sub-sea environments. The invention comprises further a light-source attachment for a powered apparatus comprising a light source embedded within a block of clear material (16) and means for mounting said block on the powered apparatus such that a connector connects the light source to a power source within the powered apparatus.

Abstract: Disclosed are various embodiments for a call control application bridges communication devices with a media call. In one embodiment, the call control application receives a request to place a media call from a source device to a destination device. The call control application determines if at least one of the source device and the destination device is associated with a telephone number registered in a relay registry. In response to a determination that the telephone number is registered in the registry, the call control application directs an intermediary agent to place a first media call to the source device and a second media call to the destination device. The call control application then bridges the first media call and the second media call via the intermediary agent.

Abstract: A method and system for generating a vector graphic from a color/object coded hand-drawn diagram are provided. A digital image of the diagram is generated and the key to the color/object code used to code the diagram is obtained. The digital image is then filtered to create a color-filtered image for each color in the key. Each filtered image is analyzed to determine the object type of objects in the filtered image according to the key, and then data extracted from the analysis of the filtered images is combined into a vector graphic diagram. The use of coded color in the diagram enables the image to be filtered based on color, which in turn aids the automated recognition of components in the diagram and significantly reduces the complexity of identifying each type of shape.

Abstract: A package (10) of an infusible substance, typically tea or coffee, is disclosed. This package (10) preferably comprises a tubular structure (17) of a liquid permeable material which contains the infusible substance. The structure has a lower portion (11) and an upper portion (12) and is sealed at a lower end (13) and an upper end (14) in a manner such that when the lower portion (11) is immersed in a liquid, the infusible substance is retained substantially within the structure (17) whilst the liquid permeates the infusible substance and the upper portion (12) projects out of the liquid to facilitate gripping thereof. In this way, the package (10) containing tea leaves, may be immersed, for example, in a cup of hot water to produce tea.

Abstract: A printing device is described, predominantly for printing labels on a tape. The printing device has a display and input means for inputting characters to be printed by the printing device. Using the input means, a cursor on the display can be controlled. The printing device has a label memory which comprises a storage portion having a plurality of storage sections. The display is operable to display a plurality of label access elements each of which represents a respective storage section in the storage portion of the memory. The cursor is used to access a selected storage section of the memory associated with the label access element identified by the cursor position. A method of storage label data in a label memory using this principle is also described.

Abstract: A printing device for printing labels that includes a display; a user input means for inputting an image to be printed by the printing device and for selecting a required label length; and a control means operable to determine the length of the image input via the user input means, and if 10 the length of the image input is greater than the required label length, the control means is arranged to cause the display to display an error message indicating the difference between the length of the image and the required label length, which may be the minimum length of the inputted image, the difference between a preselected length and the minimum length of the inputted image, or both.