Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: The present invention provides a method for producing desired proteins or chemicals in fungal host cells, which comprise modulating the nucleic acid encoding proteins associated with hyphal growth. The amino acid and nucleic acid sequences of hbrA and hbrB are provided.

Abstract: A fuel delivery system is disclosed which includes a purge device which comprises a compressor (30) which includes a tank (32) for supplying compressed air to a line (34) which is connected to a fuel line (24). The compressed air is supplied to a point between a fuel tank (22) and a pump (26) to push fuel back into the tank (22) or through the pump (26) then through an injector (20) and back through a return line (28) to the tank so that the fuel line is completely purged of fuel.

Abstract: The present invention provides a method for producing desired proteins or chemicals in fungal host cells, which comprise modulating the nucleic acid encoding proteins associated with hyphal growth. The amino acid and nucleic acid sequences of hbrA and hbrB are provided.

Abstract: A power supply (1) for a load in the form of a PCMCIA card (2) has and onboard GPRS class (10) module (not shown). The module, and therefore card (2), demands a load current iload that has an average value over time and periodic instantaneous peak values (ipeak) that are significantly higher than the average value. Power supply (1) includes a pair of input terminals (3) for connecting with a power source in the form of a regulated power supply (4) that is contained within a personal computer (not shown). Supply (4) supplies a source current iinput that is less than a predetermines current limit specified for the supply and which is less than the peak load current. A pair of output terminals (5) is electrically connected with terminals (3) and card (2). A supercapacitor device in the form of a single supercapacitor (6) is in parallel with terminals (3, 5) for allowing the load to be supplied the peak load current while maintaining the source current at less than the predetermined current limit.

Abstract: A resistive balance (1) for an energy storage device in the form of a supercapacitor (2). The supercapacitor has two energy storage cells (3, 4). In some embodiments, the balance is disposed intermediate the cells. Balance (1) includes two parallel, spaced apart and co-extensive longitudinal members (5, 6) that respectively extend between ends (7, 8) and ends (9, 10). Two parallel, spaced apart and co-extensive transverse members (11, 12) extend between members (5, 6). While member (11) is attached to members (7, 8) immediately adjacent to ends (7, 9) respectively, member (12) is attached to members (7, 8) adjacent to but spaced inwardly from respective ends (8, 10).

Abstract: A fuel delivery system for an engine is disclosed which includes an injector (20) and a housing (3) for supporting a fuel injector (20). A regulator (202, 313) is provided for regulating the pressure of fluid in the housing to maintain the pressure at about supply pressure, and the pressure downstream of the regulator at a low pressure so that fuel which passes the regulator is able to evaporate. The evaporated fuel is supplied to a heater (250) to heat the fuel, and the vapour is supplied to a vapour injector (260) for injection into the engine. The passage of the liquid petroleum gas fuel through the housing (3) cools the injector (20) to maintain the fuel in a liquid state, and therefore prevent boiling of the vapour within the injector.

Abstract: The present invention provides a method for producing desired proteins or chemicals in fungal host cells which comprise modulating the nucleic acid encoding proteins associated with hyphal growth. The amino acid and nucleic acid sequence of hbrA is provided.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: A power supply is for an electrical load in the form of a Notebook computer. The power supply includes first terminals which extend from the computer for releasably electrically connecting with a first energy storage device in the form of a battery during a first interval. A second energy storage device, in the form a second battery, releasably electrically connects with terminals during a second interval spaced apart from the first interval. This allows power to be supplied to the load during those intervals. A capacitive energy storage device supplies power to the load during a third interval that spans the spacing between the first and the second intervals.

Abstract: A power supply (1) for a pulsed load (2) includes a first energy storage device in the form of a battery (3) which is in parallel with a second energy storage device in the form of a supercapacitor (4) Battery (3) and supercapacitor (4) are respectively modelled as: an ideal battery (7) in series with an internal resistance (8); and an ideal capacitor (9) in series with an equivalent series resistance (ESR) (10). Through use of a supercapacitor (4) having a low ESR with respect to the resistance (8), the power supply (1) facilitates continuity of supply to load (2). That is, during peak demand more of the load current will be supplied by supercapacitor (4) due to the lower ESR. Moreover, during times of lower load current demands the battery recharges the supercapacitor. This reduces the peak current needed to be provided by the battery and thereby improves battery longevity.

Abstract: The present invention provides a method for producing desired proteins or chemicals in fungal host cells, which comprise modulating the nucleic acid encoding proteins associated with hyphal growth. The amino acid and nucleic acid sequences of hbrA and hbrB are provided.

Abstract: The object of this invention is a procedure for obtaining a genetically altered merodiploid strain of Penicillium chrysogenum in which the activity of a regulating gene that controls penicillin biosynthesis has been altered, so that this strain is an overproducer of penicillin. This invention represents the first case in which the biosynthesis of a metabolite of industrial interest has been increased by the manipulation of a regulating gene, and therefore is a considerable novelty compared with the previously used technologies.

Abstract: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal growth. Specifically, the present invention is directed to a full length cotA gene, its gene product and methods of use.

Abstract: DNA encoding the gene for the synthetase enzyme capable of generating &dgr; (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenum, cephalosporium and a Flavobacterium species. The DNA was used to prepare recombinant vectors comprising the ACV synthetase gene and hosts transformed with such vectors. The ACV synthetase gene can form part of a gene cluster comprising other genes involved in -&bgr;-lactam biosynthesis and the production of penicillin by expression of the entire biosynthetic gene cluster for the synthesis of penicillin from primary amino acids is described. Suitable hosts in which expression can take place include heterologous hosts which are naturally non-producers of penicillin.