Abstract: An immune response against an antigen is induced by stimulation with a two-component vaccine that includes an antiidiotypic antibody as one of the components. An immune response against an antigen is also induced by stimulation with other two-component vaccines. Stimulation by a two-component vaccine may be followed by stimulation with a monoclonal broadly neutralizing anti-HIV antibody or with one of the components of the two-component vaccine. This method of inducing immunity has applications in vaccines against infectious pathogens and in therapeutic and preventive vaccines against cancers.

Abstract: Substances that bind to alloimmune-immunogen-absorbed (AIA) sera have been found to be effective in the prevention and therapy of autoimmune disease. It is conjectured that the mechanism involves indirect stimulation of suppressor T cells resulting in stabilization of the immune system. The administration of such substances is expected to be useful in the prevention and treatment of diseases that involve a failure of the immune system to distinguish adequately between self and nonself, including autoimmune diseases and immunodeficiency diseases.