Patents by Inventor Geoffrey W. Tregear
Geoffrey W. Tregear has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9056922Abstract: Provided herein are modified relaxin polypeptides wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid. Also provided are modified relaxin polypeptides comprising at least an A and a B chain, wherein the A and B chains are derived from different naturally occurring relaxins and wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid.Type: GrantFiled: October 30, 2008Date of Patent: June 16, 2015Assignee: HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINEInventors: Ross Alexander David Bathgate, Mohammed Akhter Hossain, Chrishan Surendran Samuel, John Desmond Wade, Geoffrey W Tregear
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Publication number: 20110092418Abstract: Provided herein are modified relaxin polypeptides wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid. Also provided are modified relaxin polypeptides comprising at least an A and a B chain, wherein the A and B chains are derived from different naturally occurring relaxins and wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid.Type: ApplicationFiled: October 30, 2008Publication date: April 21, 2011Applicant: FLOREKY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINEInventors: Ross Alexander David Bathgate, Mohammed Akhter Hossain, Chrishan Surendran Samuel, John Desmond Wade, Geoffrey W. Tregear
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Patent number: 6265156Abstract: A method for determining the presence and location in animal or plant tissue of a specific polynucleotide population comprising: (a) preparing a section of the tissue to be examined; (b) contacting the tissue section under hybridization conditions with a synthetic, labelled oligonucleotide probe which is complementary to a representative portion of the target polynucleotide; (c) removing unhybridized probe material from the tissue section; and (d) detecting or identifying the locations in the tissue section where labelling or hybridization of the labelled probe has occurred. A diagnostic kit for use in performance of the above method is also disclosed.Type: GrantFiled: July 7, 1997Date of Patent: July 24, 2001Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: John P. Coghlan, Jennifer D. Penschow, Geoffrey W. Tregear, Hugh D. Niall
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Patent number: 5597692Abstract: A method for determining the presence and location in animal or plant tissue of a specific polynucleotide population comprising: (a) preparing a section of the tissue to be examined; (b) contacting the tissue section under hybridization conditions with a synthetic, labelled oligonucleotide probe which is complementary to a representative portion of the target polynucleotide; (c) removing unhybridized probe material from the tissue section; and (d) detecting or identifying the locations in the tissue section where labelling by hybridization of the labelled probe has occurred. A diagnostic kit for use in performance of the above method is also disclosed.Type: GrantFiled: December 30, 1988Date of Patent: January 28, 1997Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: John P. Coghlan, Jennifer D. Penschow, Geoffrey W. Tregear, Hugh D. Niall
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Patent number: 5525465Abstract: Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Conjugates may be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of the oligonucleotide. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.Type: GrantFiled: January 3, 1995Date of Patent: June 11, 1996Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Jim Haralambidis, Geoffrey W. Tregear
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Patent number: 5326694Abstract: Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: April 20, 1992Date of Patent: July 5, 1994Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Peter J. Hudson, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 5320953Abstract: Genes and DNA transfer vector for the expression of human prepororelaxin; subunits thereof, including genes and transfer vectors for expression of human profelaxin and the individual A, B and C peptide chains thereof; and equivalents of al such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: July 29, 1992Date of Patent: June 14, 1994Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Peter J. Hudson, John Shine, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 5179195Abstract: Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: March 6, 1991Date of Patent: January 12, 1993Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Peter J. Hudson, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 5145962Abstract: Genes and DNA transfer vector for the expression of human preprorelaxin; subunits thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: April 8, 1991Date of Patent: September 8, 1992Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Peter J. Hudson, John Shine, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 5053488Abstract: Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Method for synthesis of the peptides involving recombinant DNA techniques are provided.Type: GrantFiled: July 6, 1990Date of Patent: October 1, 1991Assignee: Howard Florey Institute of Experimental Physiology & MedicineInventors: Peter J. Hudson, John Shine, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 5053331Abstract: DNA sequence of S-genes which encode S-proteins and control the self-incompatibility reaction in gametophytic self-incompatible plants have been identified. The DNA sequence encoding several S-proteins of N. alata and their attendant signal sequences are specifically provided. Regulatory sequences which direct expression of the S-genes in reproduction tissue of self-incompatible plants have also been identified. A method for the identification and isolation of cDNA and genomic DNA coding sequences of the S-genes is described.Type: GrantFiled: May 25, 1988Date of Patent: October 1, 1991Assignee: Lubrizol Genetics, Inc.Inventors: Adrienne Clarke, Shaio Lim Mau, Marilyn Anderson, Edwina Cornish, Hugh D. Niall, Geoffrey W. Tregear, Robert J. Crawford, Robert Bernatzky
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Patent number: 5023321Abstract: Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: March 4, 1987Date of Patent: June 11, 1991Assignee: Howard Florey Institute of Experimental Physiology & MedicineInventors: Peter J. Hudson, High D. Niall, Geoffrey W. Tregear
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Patent number: 4871670Abstract: Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: May 12, 1986Date of Patent: October 3, 1989Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Peter J. Hudson, John Shine, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 4758516Abstract: Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.Type: GrantFiled: December 13, 1983Date of Patent: July 19, 1988Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Peter J. Hudson, Hugh D. Niall, Geoffrey W. Tregear
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Patent number: 4656249Abstract: A method for the synthesis of porcine relaxin or modified forms or analogues thereof, which comprises the steps of reducing a mixed solution of the S-sulfonated A and B peptide chains, or modified forms or analogues thereof; precipitating the reduced peptides with acetone; washing the mixed peptides; oxidizing the mixed peptides in the presence of aqueous sodium chloride; and isolating the relaxin thus produced.Also claimed are modified forms and analogues of porcine relaxin analogues which comprise shortened forms of the natural B and/or A peptide chains, and/or in which one or both of A and B chains in the full length or shortened form has been chemically modified.Type: GrantFiled: June 10, 1982Date of Patent: April 7, 1987Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Geoffrey W. Tregear, Yu-cang Du, Hugh D. Niall
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Patent number: 4105602Abstract: Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R--CH.sub.2 --O--Phe--Asn at one end of an amino acid chain, R being the resin and Phe and Asn being the residues of the amino acids phenylalanine and asparagine; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological acitivity may be derived.Type: GrantFiled: February 10, 1975Date of Patent: August 8, 1978Assignee: Armour Pharmaceutical CompanyInventors: Robert L. Colescott, Geoffrey W. Tregear