Abstract: Human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues having a modified A chain and/or a modified B chain are described. Also described are nucleic acid sequences encoded human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues. Also described are methods for the treatment of conditions responsive to administration of H3 relaxin or analogues thereof.

Abstract: This invention relates to novel oligonucleotide-polyamide conjugates preferably having a free 3' hydroxl moiety, and wherein the polyamide is coupled to the oglionucleotide through its carboxyl terminus. A nucleotide polymer conjugate of the formula (I): Nu--NUC--C.dbd.C--X.sup.1 --NH--X.sup.2 --X.sup.3 where X.sup.1 is an unsubstituted or substituted C.sub.1 -C.sub.10 alkylene group, in which one or more carbons may optionally be replaced by --NH--, --O-- or --S--; X.sup.2 is a bond, or an unsubstituted or substituted C.sub.1 -C.sub.20 alkylene group, in which one or more carbons may optionally be replaced by --NH--, --O-- or --S--; the optional substituents in X.sup.1 or X.sup.2 are selected from a variety of groups; X.sup.3 is an amino acid or a polyamide linked via its carboxy terminus; NUC is a nucleoside group of any one of formulas (a), (b), (c), (d) where.fwdarw.indicates the bond to the --C--C-- group in formula (I), and X.sup.

Abstract: Methods are provided for the hybridization of a target polynucleotide with a conjugate. The conjugate comprises an oligonucleotide covalently bound to a linker that is covalently bound to an amino acid or a polyamide. The oligonucleotide portion of the conjugate comprises an anti-sense sequence which is complementary to and hybridizes with the target polynucleotide. The method is useful for detecting the presence of viral or bacterial target polynucleotides.

Abstract: Conjugates of the type Z--X--L are described wherein Z is a solid phase matrix, X is a single amino acid or a polyamide of two or more amino acid residues, and L is a linker that is capable of linking between the amino terminus of X and a 3'-phosphate of a nucleotide. Conjugates may also be synthesized by assembling a polyamide on a solid support matrix, adding a suitable linker molecule, followed by synthesis of an oligonucleotide thereon. Methods for detecting specific polynucleotides with oligonucleotide-polyamide conjugates are also described.

Abstract: A peptide chosen from the group comprising [Ala.sup.1 ]-HPTH-(1-X) and HPTH-(1-X) wherein X is an integer from 27 to 34.