Patents by Inventor Georg Dahmann

Georg Dahmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE-IMIDAZOPYRIDINE DERIVATIVES
    Publication number: 20260199325
    Abstract: The present invention relates to compounds of formula(I), a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, Xa, Xb, Xc, Xd, A, R1 and R6 have meanings given in the description.
    Type: Application
    Filed: December 8, 2023
    Publication date: July 16, 2026
    Inventors: Roland PFAU, Georg DAHMANN, Kai GERLACH, Riccardo GIOVANNINI, Johann Faustus DU HOFFMANN, Christoph HOHN, Stefan JUST, Heiko SOMMER, Christian SPECKER
  • Dioxane derivatives
    Patent number: 12655136
    Abstract: The present invention relates to substituted dioxane derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of neuronal and non-neuronal conditions having an association with mGluR4 function and/or in the treatment of obesity by means of mGluR4 modulation.
    Type: Grant
    Filed: October 27, 2023
    Date of Patent: June 16, 2026
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Georg Dahmann, Johann Faustus Du Hoffmann, Kai Gerlach, Riccardo Giovannini, Christoph Hohn, Stefan Just, Thorsten Lehmann, Anton Pekcec, Julia Schlichtiger, Heiko Sommer, Christian Specker
  • Substituted tetrazoles as TRPA1 inhibitors
    Patent number: 12497401
    Abstract: This invention related to substituted tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: December 16, 2025
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Georg Dahmann, Joerg P. Hehn, Uta Friederike Lessel, Jens Willwacher
  • HETARYL SUBSTITUTED INDAZOLES AND BENZIMIDAZOLES AS STING ANTAGONISTS AND THE USE THEREOF AS MEDICAMENT
    Publication number: 20250333414
    Abstract: This invention relates to compounds of formula (1) and their use in the prevention, delaying and/or treatment of diseases or conditions which can be influenced by STING inhibition.
    Type: Application
    Filed: April 28, 2025
    Publication date: October 30, 2025
    Inventors: Matthias HOFFMANN, Marta BRAMBILLA, Georg DAHMANN, Patrick GROSS, Jun LI, Camilla MAYER, Herbert NAR, Thorsten OOST, Theodor THEIS
  • MONOARYL AND HETARYL SUBSTITUTED INDAZOLES AND BENZIMIDAZOLES AS STING ANTAGONISTS AND THE USE THEREOF AS MEDICAMENT
    Publication number: 20250333398
    Abstract: This invention relates to compounds of formula (I) and their use in the prevention, delaying and/or treatment of diseases or conditions which can be influenced by STING inhibition.
    Type: Application
    Filed: April 28, 2025
    Publication date: October 30, 2025
    Inventors: Matthias HOFFMANN, Georg DAHMANN, Patrick GROSS, Jun LI, Herbert NAR, Thorsten OOST
  • Substituted pyrazine-carboxamide derivatives
    Patent number: 12421218
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Grant
    Filed: August 14, 2024
    Date of Patent: September 23, 2025
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Georg Dahmann, Johann Faustus Du Hoffmann, Kai Gerlach, Riccardo Giovaninni, Christoph Hohn, Stefan Just, Thorsten Lehmann, Anton Pekcec, Stefan Peters, Julia Schlichtiger, Heiko Sommer, Christian Specker, Dieter Wiedenmayer
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250250251
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: January 30, 2025
    Publication date: August 7, 2025
    Inventors: Jens WILLWACHER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Christian Andreas KUTTRUFF, Sophia Astrid REINDL
  • PIPERIDINYLBENZONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250250252
    Abstract: The present disclosure provides certain piperidinylphenylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: January 30, 2025
    Publication date: August 7, 2025
    Inventors: Jens WILLWACHER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Christian Andreas KUTTRUFF, Sophia Astrid REINDL
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250066329
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 27, 2025
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250059166
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 20, 2025
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250059165
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 20, 2025
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Publication number: 20240417394
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Application
    Filed: August 14, 2024
    Publication date: December 19, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANINNI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Stefan PETERS, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER, Dieter WIEDENMAYER
  • PHENYLPIPERIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20240317712
    Abstract: The present disclosure provides certain phenylpiperidine derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: March 12, 2024
    Publication date: September 26, 2024
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • Heterocyclic compounds capable of activating STING
    Patent number: 12065427
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: August 20, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Sebastian Carotta, Georg Dahmann, Cédrickx Godbout, Sandra Ruth Handschuh, Herbert Nar, Thorsten Oost, Ulrich Reiser, Matthias Treu
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240270718
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Application
    Filed: March 6, 2024
    Publication date: August 15, 2024
    Inventors: Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Ulrich REISER, Matthias TREU
  • PHENYLPIPERIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20240246981
    Abstract: The present disclosure provides certain phenylpiperidine derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: December 18, 2023
    Publication date: July 25, 2024
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Publication number: 20240182453
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Application
    Filed: October 27, 2023
    Publication date: June 6, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANINNI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Stefan PETERS, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER, Dieter WIEDENMAYER
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240174642
    Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.
    Type: Application
    Filed: October 24, 2023
    Publication date: May 30, 2024
    Inventors: Keith Andrew Newton GRAHAM, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Ulrich REISER, Esther SCHMIDT, Matthias TREU
  • NOVEL DIOXANE DERIVATIVES
    Publication number: 20240174652
    Abstract: The present invention relates to substituted dioxane derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of neuronal and non-neuronal conditions having an association with mGluR4 function and/or in the treatment of obesity by means of mGluR4 modulation.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 30, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANNINI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240174641
    Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.
    Type: Application
    Filed: October 24, 2023
    Publication date: May 30, 2024
    Inventors: Keith Andrew Newton GRAHAM, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Timo MISSEL, Herbert NAR, Thorsten OOST, Ulrich REISER, Esther SCHMIDT, Matthias TREU