Patents by Inventor Georg Dahmann

Georg Dahmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250250251
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: January 30, 2025
    Publication date: August 7, 2025
    Inventors: Jens WILLWACHER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Christian Andreas KUTTRUFF, Sophia Astrid REINDL
  • PIPERIDINYLBENZONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250250252
    Abstract: The present disclosure provides certain piperidinylphenylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: January 30, 2025
    Publication date: August 7, 2025
    Inventors: Jens WILLWACHER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Christian Andreas KUTTRUFF, Sophia Astrid REINDL
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250066329
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 27, 2025
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250059166
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 20, 2025
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20250059165
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2024
    Publication date: February 20, 2025
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Publication number: 20240417394
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Application
    Filed: August 14, 2024
    Publication date: December 19, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANINNI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Stefan PETERS, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER, Dieter WIEDENMAYER
  • PHENYLPIPERIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20240317712
    Abstract: The present disclosure provides certain phenylpiperidine derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: March 12, 2024
    Publication date: September 26, 2024
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • Heterocyclic compounds capable of activating STING
    Patent number: 12065427
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: August 20, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Sebastian Carotta, Georg Dahmann, Cédrickx Godbout, Sandra Ruth Handschuh, Herbert Nar, Thorsten Oost, Ulrich Reiser, Matthias Treu
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240270718
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Application
    Filed: March 6, 2024
    Publication date: August 15, 2024
    Inventors: Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Ulrich REISER, Matthias TREU
  • PHENYLPIPERIDINE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20240246981
    Abstract: The present disclosure provides certain phenylpiperidine derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: December 18, 2023
    Publication date: July 25, 2024
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL, James Young Soo YANG HAMILTON
  • NOVEL SUBSTITUTED PYRAZINE-CARBOXAMIDE DERIVATIVES
    Publication number: 20240182453
    Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.
    Type: Application
    Filed: October 27, 2023
    Publication date: June 6, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANINNI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Stefan PETERS, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER, Dieter WIEDENMAYER
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240174642
    Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.
    Type: Application
    Filed: October 24, 2023
    Publication date: May 30, 2024
    Inventors: Keith Andrew Newton GRAHAM, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Ulrich REISER, Esther SCHMIDT, Matthias TREU
  • NOVEL DIOXANE DERIVATIVES
    Publication number: 20240174652
    Abstract: The present invention relates to substituted dioxane derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of neuronal and non-neuronal conditions having an association with mGluR4 function and/or in the treatment of obesity by means of mGluR4 modulation.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 30, 2024
    Inventors: Roland PFAU, Georg DAHMANN, Johann Faustus DU HOFFMANN, Kai GERLACH, Riccardo GIOVANNINI, Christoph HOHN, Stefan JUST, Thorsten LEHMANN, Anton PEKCEC, Julia SCHLICHTIGER, Heiko SOMMER, Christian SPECKER
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240174641
    Abstract: The present invention relates to compounds of formula (I) which are capable of activating STING (Stimulator of Interferon Genes). The present invention further relates to pharmaceutical compositions comprising at least a compound of formula (I), as well as the use of these compounds or the pharmaceutical compositions as a medicament, e.g., for treating canine or feline cancer, or as vaccine adjuvants.
    Type: Application
    Filed: October 24, 2023
    Publication date: May 30, 2024
    Inventors: Keith Andrew Newton GRAHAM, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Timo MISSEL, Herbert NAR, Thorsten OOST, Ulrich REISER, Esther SCHMIDT, Matthias TREU
  • HETEROCYCLIC COMPOUNDS CAPABLE OF ACTIVATING STING
    Publication number: 20240166629
    Abstract: The present invention relates to heterocyclic compounds of formula (I) capable of activating STING (Stimulator of Interferon Genes).
    Type: Application
    Filed: October 24, 2023
    Publication date: May 23, 2024
    Inventors: Ulrich REISER, Sebastian CAROTTA, Georg DAHMANN, Cédrickx GODBOUT, Sandra Ruth HANDSCHUH, Herbert NAR, Thorsten OOST, Matthias TREU
  • NOVEL TETRAZOLES
    Publication number: 20240101561
    Abstract: This invention relates to tetrazoles and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Application
    Filed: October 14, 2020
    Publication date: March 28, 2024
    Inventors: Martin Thomas FLECK, Florian Paul Christian BINDER, Georg DAHMANN, Joerg P. HEHN, Uta Friederike LESSEL, Jens WILLWACHER
  • PIPERIDINYLPYRIDINYLCARBONITRILE DERIVATIVES AS INHIBITORS OF GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE AND GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE LIKE PROTEIN
    Publication number: 20240059675
    Abstract: The present disclosure provides certain piperidinylpyridinylcarbonitrile derivatives, and pharmaceutically acceptable salts thereof, that are inhibitors of Glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), and are therefore useful for the treatment of diseases treatable by inhibition of QPCT/L. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 22, 2024
    Inventors: Jens WILLWACHER, Florian Paul Christian BINDER, Georg DAHMANN, James Young Soo YANG HAMILTON, Sandra Ruth HANDSCHUH, Sophia Astrid REINDL
  • Substituted 1,2,4-oxadiazoles as TRPA1 inhibitors
    Patent number: 11878981
    Abstract: The present disclosure provides certain substituted 1,2,4-oxadiazole derivatives of the below formula (I) that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: January 23, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Georg Dahmann, Martin Thomas Fleck, Annekatrin Charlotte Heimann, Thorsten Oost
  • MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
    Publication number: 20230372297
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as herein, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: August 2, 2023
    Publication date: November 23, 2023
    Inventors: John Edward PARK, Gerald Juergen ROTH, Armin HECKEL, Nveed CHAUDHARY, Trixi BRANDL, Georg DAHMANN, Matthias GRAUERT
  • Thienopyrimidones
    Patent number: 11578080
    Abstract: This invention relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: February 14, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Thomas Fleck, Florian Paul Christian Binder, Georg Dahmann, Joerg P. Hehn, Annekatrin Charlotte Heimann, Uta Friederike Lessel, Jens Willwacher