Abstract: The invention relates to supravalent peptide compounds depicting an enhanced efficacy. Supravalent compounds comprise several at least bivalent peptide units that bind to a receptor target and are connected to a large polymeric carrier unit.

Abstract: The present invention relates to improvements for a fast setup of physical communication channels in a CDMA-based communication system. A Node B of a telecommunication network is permitted to manage and assign a certain share of the downlink transmission resources of a radio network controller without inquiry of said radio network controller. On reception of a resource request message from a user equipment, the node B derives and specifies a certain amount of said resources that can be allocated to the user equipment. In a preferred embodiment of the present invention said resources are only assigned temporarily until the ordinary RL setup procedure, which involves the RNC, has been successfully finished.

Abstract: A fuel cell includes an electrolyte electrode assembly having a cathode disposed on a first side and an anode disposed on a second side of the electrolyte electrode assembly, a first flow module disposed adjacent the cathode, and a second flow module disposed adjacent the anode. At least one of the first and second flow modules includes a material suitable for exothermal hydride formation. In addition, a method for cold-starting a such fuel cell that includes at least one of the first and second flow modules with a hydrogen-containing gas so as to induce the exothermic hydride formation and release heat; and heating the fuel cell using the heat.

Abstract: In order to correct frequency deviations of signals in a multicarrier system, such as a OFDM-system, the present invention provides a frequency tracker and a method to operate the same. The frequency tracker is based on a decision directed digital phase locked loop exhibiting a predictive character. On the basis of an estimated phase offset for a received signal (signal component, signal symbol) a predicted phase offset is calculated and applied to the signal (signal component, signal symbol). Further, received signals (signal components, signal symbols) are sampled and for each sample a sample phase offset to be corrected is calculated in dependence to the related estimated phase offset to incorporate the predictive character.

Abstract: A method of assessing the titre of fertility-relevant autoantibodies of a mammalian female, wherein said method comprises: the presentation of a defined single molecule capable of binding to the idiotype of the fertility-relevant autoantibody, and determining the amount of autoantibody being bound by said molecule from a sample of a body fluid of said mammalian female.

Abstract: The present invention therefore presents modules from which helical constraints can be built by very flexible strategies. The peptide bonds involved partially compensate the hydrophobic nature of the disulfide bonds, which are also included into the constraint strategy. Thus, the invention presents solutions, by means of which peptide bonds or closure of disulfide bridges can be used alternatively for closure of the constraint. This offers greater synthetic flexibility. Moreover, the peptide bonds are more hydrophilic than disulfide bridges alone and offer the advantage of better solubility of the product in an aqueous surrounding. It is possible to attach solvation tags like glycosyl moieties, polyethylenglycol or other suitable extensions or appendices to the helical constraint structure. Usually, such a hydrophilic helical constraint structure replaces two hydrophobic amino acid side chains and thus improves pharmacologic properties of the molecule.

Abstract: In a synchronization scheme, for example for establishing a channel in a UMTS radio communication system, when a user device (or user equipment, UE) such as a mobile terminal is establishing a channel with a network, the user device transmits signals on the uplink DPCCH, and the power of these signals is ramped up from a calculated initial power level until the transmission is detected by the receiver, i.e. until the receiver has obtained synchronization to the uplink signal.

Abstract: The invention pertains to binding molecules consisting of a carrier structure of at least one cyclic molecular subunit and at least two side chain subunits, wherein the side chain subunits are polypeptide chains consisting of natural and/or unnatural D- and/or L-amino acids and the side chain subunits are covalently bonded to the support structure.

Abstract: Use of an activated solid phase and an anchoring part which is attached to a peptide for solid phase peptide synthesis, wherein the anchoring part is coordinatively and reversibly attached to the activated solid phase. Furthermore provided is a process for competitively detachment of said anchoring part, for purification and refolding of said peptides. Provided are peptides with an anchoring part for coordinative and reversible attachment of said peptides to an activated solid phase.

Abstract: Peptides, methods for the preparation thereof, medicaments containing the peptides, and their use in selected indications, such as the treatment of various forms of anemia and stroke.

Abstract: A method of preventing amplitude peaks from appearing in a processed signal that has been generated from at least one baseband signal by one or more signal processing operations is described. The method includes two or more individual peak cancellation steps, each peak cancellation step including deriving an estimate for the processed signal, assessing the estimate to detect amplitude peaks, and adjusting the baseband signal to prevent any detected amplitude peaks from appearing in the processed signal later on. The invention also relates to a peak cancellation stage for efficiently performing peak cancellation.

Abstract: A method, a computer program product and a device for requesting access to a node (BS) of a wireless communications network (10) are described. In the network (10) identification codes are used to differentiate access requests of different network components (UE). The method comprises the step of determining information about a transmission path (12) to e.g. the network node (BS), the step of determining an identification code in dependence on the determined transmission path information, wherein previously an association between identification codes and transmission path information has been established, and the step of modulating the selected identification code onto a signal to generate an access request signal carrying transmission path information.

Abstract: A method for the preparation of specific monoclonal immunological binding molecules having binding capacity to mammal epitopes, comprising the following steps: a) isolation of structures containing said epitopes to obtain an epitope preparation; b) immunization of non-mammals with the epitope preparation to obtain an immune response; c) immortalization of the immune response to obtain a library of immunological binding molecules; d) selection of the immunological binding molecules by means of the epitopes to obtain specific monoclonal immunological binding molecules. The specific monoclonal immunological binding molecules obtained can be used for identifying, in a library of low molecular weight substances, those having a high binding affinity, thus mimicking the epitopes of mammals.

Abstract: In a synchronization scheme, for example for establishing a channel in a UMTS radio communication system, when a user device (or user equipment, UE) such as a mobile terminal is establishing a channel with a network, the user device transmits signals on the uplink DPCCH, and the power of these signals is ramped up from a calculated initial power level until the transmission is detected by the receiver, i.e. until the receiver has obtained synchronization to the uplink signal.

Abstract: Membranes comprising sulfonated polyether ketone and another polymer, process for their production, and their use, Membranes comprising from 30 to 99.5% by weight of a sulfonated, strictly alternating polyether ketone (A) having repeat units of the formula (I) —Ar—O—Ar?—CO—, where Ar and Ar?, independently of one another, are bivalent aromatic radicals, with an ion exchange capacity of from 1.3 to 4.0 meq of —SO3H/g of polymer and from 0.5 to 70% by weight of a partially fluorinated, nonfluorinated or perfluorinated polymer (B) are described. The membranes may be used in fuel cells.

Abstract: A protein which is homologous with chicken VL or VH to at least 80% and inhibits syncytial fusion, as well as fragments having at least 12 continuous amino acids from the sequence of chicken VL or VH.

Abstract: A novel non-aggressive sulfonating process for aromatic polymers is described. The process encompasses: a). dissolving the aromatic polymer in a substantially anhydrous acid selected from the group consisting of concentrated sulfuric acid, chlorosulfonic acid, and oleum, b) adding an organic solvent which is inert under the conditions of the reaction, c) adding a carboxylic anhydride, d) adding a sulfonating agent, and e) carrying out the sulfonation at a temperature below 25° C. and for a time sufficient to achieve the desired degree of sulfonation.

Abstract: The invention relates to a fuel cell consisting of one or more individual cells, wherein an individual cell is comprised of electrolyte-electrodes unit, means for gas distribution of reactants to the electrodes and an electric contacting of the individual cells. The inventive fuel cell has the following characteristics: the electrodes comprise electrically conductive, regularly disposed micro or nanoscale needle-shaped or tubular-shaped electrode elements affixed on a gas-permeable carrier substrate and coated with a catalyst; the electrode elements are fully or partially surrounded on the outside by the material of the electrolytes; the catalytic reaction zones in the electrode elements are connected to the means for gas distribution by the gas-permeable carrier substrate; the electrode elements are connected to one another and to the electric contacting of the individual cells in an electrically conductive manner.

Abstract: In order to correct frequency deviations of signals in a multicarrier system, such as a OFDM-system, the present invention provides a frequency tracker and a method to operate the same. The frequency tracker is based on a decision directed digital phase locked loop exhibiting a predictive character. On the basis of an estimated phase offset for a received signal (signal component, signal symbol) a predicted phase offset is calculated and applied to the signal (signal component, signal symbol). Further, received signals (signal components, signal symbols) are sampled and for each sample a sample phase offset to be corrected is calculated in dependence to the related estimated phase offset to incorporate the predictive character.

Abstract: The composition described comprises 30 to 99.5% by weight of a sulfonated aromatic polyether ketone which has an ion-exchange capacity of from 1.3 to 4.0 meq (—SO3H)/g of polymer, and from 0.5 to 70% by weight of a polybenzimidazole.