Patents by Inventor Georg H. Watzig
Georg H. Watzig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9573989Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.Type: GrantFiled: April 17, 2015Date of Patent: February 21, 2017Assignee: Conaris Research Institute AGInventors: Georg H. Wätzig, Dirk Seegert
-
Publication number: 20150361157Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.Type: ApplicationFiled: April 17, 2015Publication date: December 17, 2015Inventors: Georg H. Wätzig, Dirk Seegert
-
Patent number: 9034817Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.Type: GrantFiled: December 17, 2013Date of Patent: May 19, 2015Assignee: CONARIS RESEARCH INSTITUTE AGInventors: Georg H. Wätzig, Dirk Seegert
-
Patent number: 8895012Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.Type: GrantFiled: June 29, 2007Date of Patent: November 25, 2014Assignee: Conaris Research Institute AGInventors: Georg H. Wätzig, Dirk Seegert
-
Publication number: 20140178378Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.Type: ApplicationFiled: December 17, 2013Publication date: June 26, 2014Applicant: Conaris Research Institute AGInventors: Georg H. Wätzig, Dirk Seegert
-
Publication number: 20140072984Abstract: Described are soluble gp130 polypeptide monomers and dimers, wherein, in a preferred embodiment, at least one of the three amino acid residues Thr102 GIn113 or ASn114 of the N-terminal Ig-like domain of gp130 is mutated to Tyr102, Phe113 or Leu114, respectively. These mutations, alone or in combination, specifically enhance binding of gp130 to its ligand complex of interleukin-6 and soluble interleukin-6 receptor, thus increasing the biological activity of the gp130 muteins. In a particularly preferred embodiment, all three mutations are combined in the triple mutein Thr102Tyr/Gln113Phe/Asn114Leu (T102Y/Q113F/N114L). Moreover, a pharmaceutical composition containing said monomers or dimers and various medical uses are described.Type: ApplicationFiled: June 20, 2013Publication date: March 13, 2014Applicant: Conaris Research Institute AGInventors: Joachim Grötzinger, Jürgen Scheller, Stephanie Tenhumberg, Stefan Rose-John, Georg H. Wätzig
-
Patent number: 8501696Abstract: Described are soluble gp130 polypeptide monomers and dimers, wherein, in a preferred embodiment, at least one of the three amino acid residues Thr102 Gln113 or Asn114 of the N-terminal Ig-like domain of gp130 is mutated to Tyr102, Phe113 or Leu114, respectively. These mutations, alone or in combination, specifically enhance binding of gp130 to its ligand complex of interleukin-6 and soluble interleukin-6 receptor, thus increasing the biological activity of the gp130 muteins. In a particularly preferred embodiment, all three mutations are combined in the triple mutein Thr102Tyr/Gln113Phe/Asn114Leu (T102Y/Q113F/N114L). Moreover, a pharmaceutical composition containing said monomers or dimers and various medical uses are described.Type: GrantFiled: October 15, 2008Date of Patent: August 6, 2013Assignee: Conaris Research Institute AGInventors: Joachim Grötzinger, Jürgen Scheller, Stephanie Tenhumberg, Stefan Rose-John, Georg H. Wätzig
-
Publication number: 20100028367Abstract: Described are polypeptide dimers comprising two soluble gp130 molecules wherein each of said molecules is fused to an Fc domain of an IgG1 protein and wherein the hinge region of the Fc domain is modified resulting in advantageous properties of the dimer. In a particularly preferred embodiment, the hinge region comprises the amino acid sequence motif Ala234-Glu235-Gly236-Ala237. Moreover, a pharmaceutical composition containing said dimer and various medical uses are described.Type: ApplicationFiled: June 29, 2007Publication date: February 4, 2010Applicant: CONARIS RESEARCH INSTITUTE AGInventors: Georg H. Wätzig, Dirk Seegert
-
Patent number: 7629147Abstract: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.Type: GrantFiled: February 5, 2008Date of Patent: December 8, 2009Assignee: Conaris Research Institute AGInventors: Dirk Seegert, Stefan Schreiber, Stefan Rose-John, Georg H. Watzig, Nikolaus Rahaus
-
Patent number: 7534862Abstract: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.Type: GrantFiled: June 23, 2004Date of Patent: May 19, 2009Assignee: Conaris Research Institute AGInventors: Dirk Seegert, Stefan Schreiber, Stefan Rose-John, Georg H. Watzig, Nikolaus Rahaus
-
Publication number: 20080227155Abstract: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.Type: ApplicationFiled: February 5, 2008Publication date: September 18, 2008Inventors: Dirk Seegert, Stefan Schreiber, Stefan Rose-John, Georg H. Watzig, Nikolaus Rahaus